Editorials:

James F. Winchester

Novel Changes in ß₂-Microglobulin in Dialysis Patients
Clin Chem 2005 51: 1089-1090. [Extract] [Full Text] [PDF]  

Linda Cook and Keith R. Jerome

Mass Spectrometry for Genotyping Hepatitis C Virus: A Promising New Approach
Clin Chem 2005 51: 1091-1092. [Extract] [Full Text] [PDF]  

Special Reports:

Chantal Tse, Didier Brault, Joseph Gligorov, Martine Antoine, Rainer Neumann, Jean-Pierre Lotz, and Jacqueline Capeau

Evaluation of the Quantitative Analytical Methods Real-Time PCR for HER-2 Gene Quantification and ELISA of Serum HER-2 Protein and Comparison with Fluorescence in Situ Hybridization and Immunohistochemistry for Determining HER-2 Status in Breast Cancer Patients
Clin Chem 2005 51: 1093-1101. [Abstract] [Full Text] [PDF] Data Supplement  

Molecular Diagnostics and Genetics:

Mine Y. Liu, Antonios M. Xydakis, Ron C. Hoogeveen, Peter H. Jones, E. O’Brian Smith, Kathleen W. Nelson, and Christie M. Ballantyne

Multiplexed Analysis of Biomarkers Related to Obesity and the Metabolic Syndrome in Human Plasma, Using the Luminex-100 System
Clin Chem 2005 51: 1102-1109. [Abstract] [Full Text] [PDF] Data Supplements  

Martin Hersberger, Jörg Muntwyler, Harald Funke, Jacqueline Marti-Jaun, Helmut Schulte, Gerd Assmann, Thomas F. Lüscher, and Arnold von Eckardstein

The CAG Repeat Polymorphism in the Androgen Receptor Gene Is Associated with HDL-Cholesterol but Not with Coronary Atherosclerosis or Myocardial Infarction
Clin Chem 2005 51: 1110-1115. Published online May 12, 2005; 10.1373/clinchem.2005.049262 [Abstract] [Full Text] [PDF]  

Amy E. Krafft and Jack H. Lichy

Time-Motion Analysis of 6 Cystic Fibrosis Mutation Detection Systems
Clin Chem 2005 51: 1116-1122. Published online April 28, 2005; 10.1373/clinchem.2004.047423 [Abstract] [Full Text] [PDF] Data Supplement  

Yoon Jun Kim, Soo-Ok Kim, Hyun Jae Chung, Mi Sun Jee, Byeong Gwan Kim, Kang Mo Kim, Jung-Hwan Yoon, Hyo-Suk Lee, Chung Yong Kim, Sukjoon Kim, Wangdon Yoo, and Sun Pyo Hong

Population Genotyping of Hepatitis C Virus by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry Analysis of Short DNA Fragments
Clin Chem 2005 51: 1123-1131. Published online May 12, 2005; 10.1373/clinchem.2004.047506 [Abstract] [Full Text] [PDF] Data Supplements  

K. Kay-Yin Lai, Linda Cook, Elizabeth M. Krantz, Lawrence Corey, and Keith R. Jerome

Calibration Curves for Real-Time PCR
Clin Chem 2005 51: 1132-1136. [Abstract] [Full Text] [PDF] Data Supplements  

Diego Tejedor, Sergio Castillo, Pilar Mozas, Elisa Jiménez, Mónica López, M. Teresa Tejedor, Marta Artieda, Rodrigo Alonso, Pedro Mata, Laureano Simón, Antonio Martínez, Miguel Pocoví the Spanish FH Group

Reliable Low-Density DNA Array Based on Allele-Specific Probes for Detection of 118 Mutations Causing Familial Hypercholesterolemia
Clin Chem 2005 51: 1137-1144. Published online May 12, 2005; 10.1373/clinchem.2004.045203 [Abstract] [Full Text] [PDF] Data Supplements  

Automation and Analytical Techniques:

Øivind Midttun, Steinar Hustad, Einar Solheim, Jørn Schneede, and Per M. Ueland

Multianalyte Quantification of Vitamin B₆ and B₂ Species in the Nanomolar Range in Human Plasma by Liquid Chromatography–Tandem Mass Spectrometry
Clin Chem 2005 51: 1206-1216. [Abstract] [Full Text] [PDF] Data Supplement  

Michael K. Hourfar, Uwe Michelsen, Michael Schmidt, Annemarie Berger, Erhard Seifried, and W. Kurt Roth

High-Throughput Purification of Viral RNA Based on Novel Aqueous Chemistry for Nucleic Acid Isolation
Clin Chem 2005 51: 1217-1222. [Abstract] [Full Text] [PDF] Data Supplements  

Michael E. Rybak, Ram B. Jain, and Christine M. Pfeiffer

Clinical Vitamin B₆ Analysis: An Interlaboratory Comparison of Pyridoxal 5'-Phosphate Measurements in Serum
Clin Chem 2005 51: 1223-1231. Published online May 19, 2005; 10.1373/clinchem.2005.050278 [Abstract] [Full Text] [PDF] Data Supplement  

Evidence-based Laboratory Medicine and Test Utilization:

Svein Skeie, Carmen Perich, Carmen Ricos, Agnes Araczki, Andrea R. Horvath, Wytze P. Oosterhuis, Tanya Bubner, Gunnar Nordin, Rhena Delport, Geir Thue, and Sverre Sandberg

Postanalytical External Quality Assessment of Blood Glucose and Hemoglobin A_1c: An International Survey
Clin Chem 2005 51: 1145-1153. [Abstract] [Full Text] [PDF]  

Hemostasis and Thrombosis:

Liliana Carmen Rossetti, Claudia Pamela Radic, Irene Beatriz Larripa, and Carlos Daniel De Brasi

Genotyping the Hemophilia Inversion Hotspot by Use of Inverse PCR
Clin Chem 2005 51: 1154-1158. Published online April 28, 2005; 10.1373/clinchem.2004.046490 [Abstract] [Full Text] [PDF] Data Supplement  

Cinzia Fatini, Francesco Sofi, Anna Maria Gori, Elena Sticchi, Rossella Marcucci, Meri Lenti, Alessandro Casini, Calogero Surrenti, Rosanna Abbate, and Gian Franco Gensini

Endothelial Nitric Oxide Synthase –786T>C, but Not 894G>T and 4a4b, Polymorphism Influences Plasma Homocysteine Concentrations in Persons with Normal Vitamin Status
Clin Chem 2005 51: 1159-1164. Published online May 19, 2005; 10.1373/clinchem.2005.048850 [Abstract] [Full Text] [PDF]  

Proteomics and Protein Markers:

Stephen P. FitzGerald, John V. Lamont, Robert I. McConnell, and El O. Benchikh

Development of a High-Throughput Automated Analyzer Using Biochip Array Technology
Clin Chem 2005 51: 1165-1176. Published online May 12, 2005; 10.1373/clinchem.2005.049429 [Abstract] [Full Text] [PDF]  

Dorthe B. Corlin, Jette W. Sen, Søren Ladefoged, Grethe Bjerregaard Lund, Mogens H. Nissen, and Niels H.H. Heegaard

Quantification of Cleaved ß₂-Microglobulin in Serum from Patients Undergoing Chronic Hemodialysis
Clin Chem 2005 51: 1177-1184. Published online May 12, 2005; 10.1373/clinchem.2005.049544 [Abstract] [Full Text] [PDF] Data Supplements  

Lipids, Lipoproteins, and Cardiovascular Risk Factors:

Duk-Hee Lee, David R. Jacobs, Jr, Myron Gross, and Michael Steffes

Serum -Glutamyltransferase Was Differently Associated with Microalbuminuria by Status of Hypertension or Diabetes: The Coronary Artery Risk Development in Young Adults (CARDIA) Study
Clin Chem 2005 51: 1185-1191. Published online May 12, 2005; 10.1373/clinchem.2004.045872 [Abstract] [Full Text] [PDF]  

Simona Stan, Emile Levy, Edgard E. Delvin, James A. Hanley, Benoît Lamarche, Jennifer O’Loughlin, Gilles Paradis, and Marie Lambert

Distribution of LDL Particle Size in a Population-Based Sample of Children and Adolescents and Relationship with Other Cardiovascular Risk Factors
Clin Chem 2005 51: 1192-1200. Published online May 12, 2005; 10.1373/clinchem.2004.046771 [Abstract] [Full Text] [PDF]  

Endocrinology and Metabolism:

José Manuel Fernández-Real, Abel López-Bermejo, and Wifredo Ricart

Iron Stores, Blood Donation, and Insulin Sensitivity and Secretion
Clin Chem 2005 51: 1201-1205. [Abstract] [Full Text] [PDF]  

Laboratory Management:

Enzo Grossi, Roberto Colombo, Silvio Cavuto, and Carlo Franzini

The REALAB Project: A New Method for the Formulation of Reference Intervals Based on Current Data
Clin Chem 2005 51: 1232-1240. Published online May 26, 2005; 10.1373/clinchem.2005.047787 [Abstract] [Full Text] [PDF] Data Supplements  

Clinical Immunology:

Markus Ollert, Stephanie Weissenbacher, Jürgen Rakoski, and Johannes Ring

Allergen-Specific IgE Measured by a Continuous Random-Access Immunoanalyzer: Interassay Comparison and Agreement with Skin Testing
Clin Chem 2005 51: 1241-1249. Published online May 19, 2005; 10.1373/clinchem.2004.046565 [Abstract] [Full Text] [PDF] Data Supplements  

Technical Briefs:

Jean-Brice Marteau, Steve Mohr, Michèle Pfister, and Sophie Visvikis-Siest

Collection and Storage of Human Blood Cells for mRNA Expression Profiling: A 15-Month Stability Study
Clin Chem 2005 51: 1250-1252. [Extract] [Full Text] [PDF] Data Supplements  

Chia-Cheng Hung, Yi-Ning Su, Chia-Yun Lin, Chih-Chao Yang, Wang-Tso Lee, Shu-Chin Chien, Win-Li Lin, and Chien-Nan Lee

Denaturing HPLC Coupled with Multiplex PCR for Rapid Detection of Large Deletions in Duchenne Muscular Dystrophy Carriers
Clin Chem 2005 51: 1252-1256. [Extract] [Full Text] [PDF] Data Supplement  

Filomena Campagna, Francesca Fioretti, Marco Burattin, Stefano Romeo, Federica Sentinelli, Maura Bifolco, Maria Isabella Sirinian, Maria Del Ben, Francesco Angelico, and Marcello Arca

Congenital Analbuminemia attributable to Compound Heterozygosity for Novel Mutations in the Albumin Gene
Clin Chem 2005 51: 1256-1258. [Extract] [Full Text] [PDF] Data Supplements  

Claudio Chiesa, John F. Osborn, Lucia Pacifico, Guglielmo Tellan, Pier Michele Strappini, Roberto Fazio, and Giovanna Delogu

Circulating Ghrelin in Patients Undergoing Elective Cholecystectomy
Clin Chem 2005 51: 1258-1261. [Extract] [Full Text] [PDF]  

Hideaki Masuzaki, Kiyonori Miura, Kentaro Yamasaki, Shoko Miura, Koh-ichiro Yoshiura, Shuichiro Yoshimura, Daisuke Nakayama, Christophe K. Mapendano, Norio Niikawa, and Tadayuki Ishimaru

Clinical Applications of Plasma Circulating mRNA Analysis in Cases of Gestational Trophoblastic Disease
Clin Chem 2005 51: 1261-1263. Published online April 28, 2005; 10.1373/clinchem.2005.050666 [Extract] [Full Text] [PDF]  

Nathalie Sorel, Florence Chazelas, André Brizard, and Jean-Claude Chomel

Double-Gradient–Denaturing-Gradient Gel Electrophoresis for Mutation Screening of the BCR-ABL Tyrosine Kinase Domain in Chronic Myeloid Leukemia Patients
Clin Chem 2005 51: 1263-1266. [Extract] [Full Text] [PDF]  

Mohammad A. Mansoor, Ole Kristensen, Tor Hervig, Jacob A. Stakkestad, Thor Berge, Per A. Drabløs, Svanhild Rolfsen, and Tore Wentzel-Larsen

Relationship between Serum Folate and Plasma Nitrate Concentrations: Possible Clinical Implications
Clin Chem 2005 51: 1266-1268. [Extract] [Full Text] [PDF] Data Supplements  

Edzard Schwedhelm, Jing Tan-Andresen, Renke Maas, Ulrich Riederer, Friedrich Schulze, and Rainer H. Böger

Liquid Chromatography–Tandem Mass Spectrometry Method for the Analysis of Asymmetric Dimethylarginine in Human Plasma
Clin Chem 2005 51: 1268-1271. [Extract] [Full Text] [PDF] Data Supplements  

Michael Scott Rogers, Chi Chiu Wang, Tze Kin Lau, Xin Xiao, Xiao Guang Zhou, Tai Fai Fok, Kai On Chu, and Chi Pui Pang

Relationship between Isoprostane Concentrations, Metabolic Acidosis, and Morbid Neonatal Outcome
Clin Chem 2005 51: 1271-1274. [Extract] [Full Text] [PDF] Data Supplements  

Concetta Prontera, Simona Storti, Michele Emdin, Claudio Passino, Luc Zyw, Gian Carlo Zucchelli, and Aldo Clerico

Comparison of a Fully Automated Immunoassay with a Point-of-Care Testing Method for B-Type Natriuretic Peptide
Clin Chem 2005 51: 1274-1276. [Extract] [Full Text] [PDF] Data Supplements  

Martin J.N. Weinans, Ulrich Sancken, Raj Pandian, Jody M.W. van de Ouweland, Henk W.A. de Bruijn, Jozien P. Holm, and Albert Mantingh

Invasive Trophoblast Antigen (Hyperglycosylated Human Chorionic Gonadotropin) as a First-Trimester Serum Marker for Down Syndrome
Clin Chem 2005 51: 1276-1279. [Extract] [Full Text] [PDF]  

Francesc Francés, Dolores Corella, José Vicente Sorlí, Marisa Guillén, José I. González, and Olga Portolés

Validating a Rapid Method for Detecting Common Polymorphisms in the APOA5 Gene by Melting Curve Analysis Using LightTyper
Clin Chem 2005 51: 1279-1282. [Extract] [Full Text] [PDF]  

Annalisa Verri, Federico Focher, Guido Tettamanti, and Vittorio Grazioli

Two-Step Genetic Screening of Thrombophilia by Pyrosequencing
Clin Chem 2005 51: 1282-1284. [Extract] [Full Text] [PDF] Data Supplements  

Florence Le Calvez, Aune Ahman, Neeme Tonisson, Jeremy Lambert, Stéphane Temam, Paul Brennan, David G. Zaridze, Andres Metspalu, and Pierre Hainaut

Arrayed Primer Extension Resequencing of Mutations in the TP53 Tumor Suppressor Gene: Comparison with Denaturing HPLC and Direct Sequencing
Clin Chem 2005 51: 1284-1287. [Extract] [Full Text] [PDF] Data Supplements  

Grant Wu, Wei-Hua Liang, Jim Zhu, Hong Ouyang, Paul Pearson, Ren Cai, Can Liao, Qiu-Hua Mo, Dong-Lin Zhu, and Xiang-Ming Xu

Rapid, Simultaneous Genotyping of 10 Southeast Asian Glucose-6-Phosphate Dehydrogenase Deficiency–Causing Mutations and a Silent Polymorphism by Multiplex Primer Extension/Denaturing HPLC Assay
Clin Chem 2005 51: 1288-1291. [Extract] [Full Text] [PDF] Data Supplements  

Johanna Sistonen, Silvia Fuselli, Antti Levo, and Antti Sajantila

CYP2D6 Genotyping by a Multiplex Primer Extension Reaction
Clin Chem 2005 51: 1291-1295. Published online May 19, 2005; 10.1373/clinchem.2004.046466 [Extract] [Full Text] [PDF] Data Supplements  

Robert Graham, Michael Liew, Cindy Meadows, Elaine Lyon, and Carl T. Wittwer

Distinguishing Different DNA Heterozygotes by High-Resolution Melting
Clin Chem 2005 51: 1295-1298. Published online May 19, 2005; 10.1373/clinchem.2005.051516 [Extract] [Full Text] [PDF] Data Supplements  

Letters to the Editor:

Douwe de Boer, Matthias M. Erps, Will K.W.H. Wodzig, and Marja P. van Dieijen-Visser

Inadequate Attempts to Measure the Microheterogeneity of Transthyretin by Low-Resolution Mass Spectrometry
Clin Chem 2005 51: 1299-1300. [Extract] [Full Text] [PDF]  

Eric T. Fung

Inadequate Attempts to Measure the Microheterogeneity of Transthyretin by Low-Resolution Mass Spectrometry - Reply
Clin Chem 2005 51: 1300. [Extract] [Full Text] [PDF]  

Florian J. Schweigert and Jens Raila

Inadequate Attempts to Measure the Microheterogeneity of Transthyretin by Low-Resolution Mass Spectrometry - Reply
Clin Chem 2005 51: 1300-1301. [Extract] [Full Text] [PDF]  

Helen Keegan, Alison Malkin, Mairead Griffin, Fergus Ryan, and Helen Lambkin

Validation of a Multiplex PCR Assay for the Simultaneous Detection of Human Papillomavirus and Chlamydia trachomatis in Cervical PreservCyt Samples
Clin Chem 2005 51: 1301-1302. [Extract] [Full Text] [PDF] Data Supplements  

Godelieve Mariën, Gregor Verhoef, and Xavier Bossuyt

Detection of Heavy Chain Disease by Capillary Zone Electrophoresis
Clin Chem 2005 51: 1302-1303. [Extract] [Full Text] [PDF] Data Supplements  

James D. Hoyer and Regina M. Scheidt

Identification of Hemoglobin Variants by HPLC
Clin Chem 2005 51: 1303-1304. [Extract] [Full Text] [PDF]  

Alla Joutovsky, Joan Hadzi-Nesic, and Michael A. Nardi

Identification of Hemoglobin Variants by HPLC - Reply
Clin Chem 2005 51: 1305. [Extract] [Full Text] [PDF]  

Xiao Feng, Peter Taggart, LeRoy Hall, Stewart Bryant, Joseph Sansone, Michael Kemmerer, Judy Herlich, and Peter Lord

Limited Additional Release of Cardiac Troponin I and T in Isoproterenol-Treated Beagle Dogs with Cardiac Injury
Clin Chem 2005 51: 1305-1307. [Extract] [Full Text] [PDF]  

Callum G. Fraser

Quality Specifications for Imprecision of B-Type Natriuretic Peptide Assays
Clin Chem 2005 51: 1307-1309. [Extract] [Full Text] [PDF]  

Eric T. Fung and Edward Gavin

Analysis of Mass Spectrometry Profiles of the Serum Proteome
Clin Chem 2005 51: 1309. [Extract] [Full Text] [PDF]  

Kevin R. Coombes

Analysis of Mass Spectrometry Profiles of the Serum Proteome - Reply
Clin Chem 2005 51: 1309. [Extract] [Full Text] [PDF]  

Armando Tripodi, Veena Chantarangkul, Marzia Menegatti, Liliana Tagliabue, and Flora Peyvandi

Performance of Clinical Laboratories for DNA Analyses to Detect Thrombophilia Mutations
Clin Chem 2005 51: 1310-1311. [Extract] [Full Text] [PDF]  

David Cantor

Reason for Limitations of Heterophilic Blocking Tube Use on Certain Beckman Coulter Access Assays
Clin Chem 2005 51: 1311. [Extract] [Full Text] [PDF]  

Jaroslav A. Hubacek, Ales Horínek, Zdena Skodova, Vera Adamkova, Richard Ceska, Lukas Zlatohlavek, and Michal Vráblík

Hypertriglyceridemia: Interaction between APOE and APOAV Variants
Clin Chem 2005 51: 1311-1313. [Extract] [Full Text] [PDF]  

Sonya Trombino, Monica Neri, Riccardo Puntoni, Cristiano Angelini, Maura Loprevite, Alfredo Cesario, Pierluigi Granone, Andrea Imperatori, Lorenzo Dominioni, Andrea Ardizzoni, Rosangela Filiberti, and Patrizia Russo

Mutations in K-ras Codon 12 Detected in Plasma DNA Are Not an Indicator of Disease in Patients with Non-Small Cell Lung Cancer
Clin Chem 2005 51: 1313-1314. [Extract] [Full Text] [PDF]  

Michele Falco, Daniela Luciano, Maurizio Sturnio, Angela Spalletta, Domenico Scionti, Mariangela Lo Giudice, Corrado Romano, and Marco Fichera

Denaturing HPLC-Based Assay for Detection of ATRX Gene Mutations
Clin Chem 2005 51: 1314-1315. [Extract] [Full Text] [PDF] Data Supplement  

Oliver Danne, Christian Lueders, Christian Storm, Ulrich Frei, and Martin Möckel

Whole-Blood Hypercholinemia and Coronary Instability and Thrombosis
Clin Chem 2005 51: 1315-1317. [Extract] [Full Text] [PDF]  

Svetlana N. Tamkovich, Olga E. Bryzgunova, Elena Yu. Rykova, Valentina I. Permyakova, Valentin V. Vlassov, and Pavel P. Laktionov

Circulating Nucleic Acids in Blood of Healthy Male and Female Donors
Clin Chem 2005 51: 1317-1319. [Extract] [Full Text] [PDF] Data Supplement  

Book, Software, and Web Site Reviews:

Donald Rej

Managing Scientists: Leadership Strategies in Scientific Research. Alice M. Sapienza. New York: Wiley-Liss, 2004, 260 pp., $39.95, softcover. ISBN 0-471-22614-9.
Clin Chem 2005 51: 1320. [Extract] [Full Text] [PDF]  

Carl T. Wittwer

DNA from A to Z. Daniel H. Farkas. Washington, DC: AACC Press, 2004, 144 pp., $25.00 ($20.00 AACC members), softcover. ISBN 1-59425-002-2.
Clin Chem 2005 51: 1320-1321. [Extract] [Full Text] [PDF]  

Jay L. Bock

Handbook of Clinical Laboratory Testing During Pregnancy. Ann M. Gronowski, editor. Totowa, NJ: Humana Press, 2004, 474 pp., $145.00, hardcover (1 CD). ISBN 1-58829-270-3.
Clin Chem 2005 51: 1321-1322. [Extract] [Full Text] [PDF]  

The Clinical Chemist:

Compiled by David E. Bruns, Editor

Clin Chem 2005 51: 1323-1328. [Extract] [Full Text] [PDF]  

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