Editorials:

Midori Ishibashi

Standardization of Prostate-Specific Antigen (PSA) Assays: Can Interchangeability of PSA Measurements Be Improved?
Clin Chem 2006 52: 1-2. [Extract] [Full Text] [PDF]  

Jako S. Burgers

Guideline Quality and Guideline Content: Are They Related?
Clin Chem 2006 52: 3-4. [Extract] [Full Text] [PDF]  

Special Reports:

Gary L. Myers, W. Greg Miller, Josef Coresh, James Fleming, Neil Greenberg, Tom Greene, Thomas Hostetter, Andrew S. Levey, Mauro Panteghini, Michael Welch, John H. Eckfeldt for the National Kidney Disease Education Program Laboratory Working Group

Recommendations for Improving Serum Creatinine Measurement: A Report from the Laboratory Working Group of the National Kidney Disease Education Program
Clin Chem 2006 52: 5-18. Published online December 6, 2005; 10.1373/clinchem.2005.0525144 [Abstract] [Full Text] [PDF] Data Supplement  

Minireviews:

Hassan M.E. Azzazy, Maurice M.A.L. Pelsers, and Robert H. Christenson

Unbound Free Fatty Acids and Heart-Type Fatty Acid–Binding Protein: Diagnostic Assays and Clinical Applications
Clin Chem 2006 52: 19-29. Published online November 3, 2005; 10.1373/clinchem.2005.056143 [Abstract] [Full Text] [PDF]  

Johan L. Willemse and Dirk F. Hendriks

Measurement of Procarboxypeptidase U (TAFI) in Human Plasma: A Laboratory Challenge
Clin Chem 2006 52: 30-36. Published online November 18, 2005; 10.1373/clinchem.2005.055814 [Abstract] [Full Text] [PDF]  

Reviews:

Sam F.Y. Li and Larry J. Kricka

Clinical Analysis by Microchip Capillary Electrophoresis
Clin Chem 2006 52: 37-45. Published online November 18, 2005; 10.1373/clinchem.2005.059600 [Abstract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Mercè Garcia-Barceló, Man-ting So, Danny Ko-chun Lau, Thomas Yuk-yu Leon, Zheng-wei Yuan, Wei-song Cai, Vincent Chi-hang Lui, Ming Fu, Jo-Anne Herbrick, Emily Gutter, Virginia Proud, Long Li, Jacqueline Pierre-Louis, Kirk Aleck, Ernest van Heurn, Elena Belloni, Stephen W. Scherer, and Paul Kwong-hang Tam

Population Differences in the Polyalanine Domain and 6 New Mutations in HLXB9 in Patients with Currarino Syndrome
Clin Chem 2006 52: 46-52. Published online October 27, 2005; 10.1373/clinchem.2005.056192 [Abstract] [Full Text] [PDF] Data Supplement  

Mohsen Kerkeni, Faouzi Addad, Maryline Chauffert, Anne Myara, Mohamed Ben Farhat, Abdelhedi Miled, Khira Maaroufi, and François Trivin

Hyperhomocysteinemia, Endothelial Nitric Oxide Synthase Polymorphism, and Risk of Coronary Artery Disease
Clin Chem 2006 52: 53-58. Published online November 10, 2005; 10.1373/clinchem.2005.057950 [Abstract] [Full Text] [PDF]  

Evidence-Based Laboratory Medicine and Test Utilization:

Carsten Stephan, Moritz Klaas, Christian Müller, Dietmar Schnorr, Stefan A. Loening, and Klaus Jung

Interchangeability of Measurements of Total and Free Prostate-Specific Antigen in Serum with 5 Frequently Used Assay Combinations: An Update
Clin Chem 2006 52: 59-64. [Abstract] [Full Text] [PDF] Data Supplements  

Joseph Watine, Bruno Friedberg, Eva Nagy, Rita Onody, Wytze Oosterhuis, Peter S. Bunting, Jean-Christophe Charet, and Andrea Rita Horvath

Conflict between Guideline Methodologic Quality and Recommendation Validity: A Potential Problem for Practitioners
Clin Chem 2006 52: 65-72. [Abstract] [Full Text] [PDF]  

Proteomics and Protein Markers:

Leena Valmu, Annukka Paju, Marko Lempinen, Esko Kemppainen, and Ulf-Håkan Stenman

Application of Proteomic Technology in Identifying Pancreatic Secretory Trypsin Inhibitor Variants in Urine of Patients with Pancreatitis
Clin Chem 2006 52: 73-81. Published online October 27, 2005; 10.1373/clinchem.2005.056861 [Abstract] [Full Text] [PDF]  

Inger Brandt, Anne-Marie Lambeir, Jean-Marie Ketelslegers, Marc Vanderheyden, Simon Scharpé, and Ingrid De Meester

Dipeptidyl-Peptidase IV Converts Intact B-Type Natriuretic Peptide into Its des-SerPro Form
Clin Chem 2006 52: 82-87. Published online October 27, 2005; 10.1373/clinchem.2005.057638 [Abstract] [Full Text] [PDF]  

Drug Monitoring and Toxicology:

Perrine Hoet, Jean-Pierre Buchet, Laurence Decerf, Benoît Lavalleye, Vincent Haufroid, and Dominique Lison

Clinical Evaluation of a Lead Mobilization Test Using the Chelating Agent Dimercaptosuccinic Acid
Clin Chem 2006 52: 88-96. Published online October 20, 2005; 10.1373/clinchem.2005.051128 [Abstract] [Full Text] [PDF] Data Supplements  

Endocrinology and Metabolism:

José L. González-Sánchez, María J. Martínez-Calatrava, María T. Martínez-Larrad, Carina Zabena, Cristina Fernández-Pérez, Markku Laakso, and Manuel Serrano-Ríos

Interaction of the –308G/A Promoter Polymorphism of the Tumor Necrosis Factor- Gene with Single-Nucleotide Polymorphism 45 of the Adiponectin Gene: Effect on Serum Adiponectin Concentrations in a Spanish Population
Clin Chem 2006 52: 97-103. Published online October 27, 2005; 10.1373/clinchem.2005.049452 [Abstract] [Full Text] [PDF]  

Elizabeth H. Hoogendoorn, Ad R. Hermus, Femmie de Vegt, H. Alec Ross, Andre L.M. Verbeek, Lambertus A.L.M. Kiemeney, Dorine W. Swinkels, Fred C.G.J. Sweep, and Martin den Heijer

Thyroid Function and Prevalence of Anti-Thyroperoxidase Antibodies in a Population with Borderline Sufficient Iodine Intake: Influences of Age and Sex
Clin Chem 2006 52: 104-111. Published online October 27, 2005; 10.1373/clinchem.2005.055194 [Abstract] [Full Text] [PDF] Data Supplements  

Nils G. Morgenthaler, Joachim Struck, Christine Alonso, and Andreas Bergmann

Assay for the Measurement of Copeptin, a Stable Peptide Derived from the Precursor of Vasopressin
Clin Chem 2006 52: 112-119. Published online November 3, 2005; 10.1373/clinchem.2005.060038 [Abstract] [Full Text] [PDF]  

Mark M. Kushnir, Alan L. Rockwood, William L. Roberts, Elizabeth G. Pattison, Ashley M. Bunker, Robert L. Fitzgerald, and A. Wayne Meikle

Performance Characteristics of a Novel Tandem Mass Spectrometry Assay For Serum Testosterone
Clin Chem 2006 52: 120-128. Published online November 18, 2005; 10.1373/clinchem.2005.052167 [Abstract] [Full Text] [PDF]  

General Clinical Chemistry:

Helga Refsum, Carole Johnston, Anne Berit Guttormsen, and Ebba Nexo

Holotranscobalamin and Total Transcobalamin in Human Plasma: Determination, Determinants, and Reference Values in Healthy Adults
Clin Chem 2006 52: 129-137. Published online October 20, 2005; 10.1373/clinchem.2005.054619 [Abstract] [Full Text] [PDF] Supplemental Data  

Technical Briefs:

Rebecca L. Margraf, Rong Mao, W. Edward Highsmith, Leonard M. Holtegaard, and Carl T. Wittwer

Mutation Scanning of the RET Protooncogene Using High-Resolution Melting Analysis
Clin Chem 2006 52: 138-141. [Abstract] [Full Text] [PDF]  

Deanna R. Christensen, Laurie J. Hartman, Bonnie M. Loveless, Melissa S. Frye, Michelle A. Shipley, Deanna L. Bridge, Michelle J. Richards, Rebecca S. Kaplan, Jeffrey Garrison, Carson D. Baldwin, David A. Kulesh, and David A. Norwood

Detection of Biological Threat Agents by Real-Time PCR: Comparison of Assay Performance on the R.A.P.I.D., the LightCycler, and the Smart Cycler Platforms
Clin Chem 2006 52: 141-145. [Abstract] [Full Text] [PDF] Data Supplements  

Anna Pastore, Sandro De Angelis, Stefania Casciani, Rosalba Ruggia, Gianna Di Giovamberardino, Annalisa Noce, Giorgio Splendiani, Claudio Cortese, Giorgio Federici, and Mariarita Dessi'

Effects of Folic Acid Before and After Vitamin B₁₂ on Plasma Homocysteine Concentrations in Hemodialysis Patients with Known MTHFR Genotypes
Clin Chem 2006 52: 145-148. [Abstract] [Full Text] [PDF]  

Gerd Bodlaj, Markus Stöcher, Peter Hufnagl, Rainer Hubmann, Georg Biesenbach, Herbert Stekel, and Jörg Berg

Genotyping of the Lactase-Phlorizin Hydrolase –13910 Polymorphism by LightCycler PCR and Implications for the Diagnosis of Lactose Intolerance
Clin Chem 2006 52: 148-151. [Abstract] [Full Text] [PDF] Data Supplements  

Letters to the Editor:

Fatma Meriç Yilmaz and Dogan Yücel

Effect of Addition of Hemolysate on Urine and Cerebrospinal Fluid Assays for Protein
Clin Chem 2006 52: 152-153. [Extract] [Full Text] [PDF] Data Supplements  

Patrick J. Twomey and Martin H. Kroll

Errors in the Assessment of Estimated Glomerular Filtration Rate
Clin Chem 2006 52: 153. [Extract] [Full Text] [PDF]  

Anders Grubb and Jonas Björk

Errors in the Assessment of Estimated Glomerular Filtration Rate: Reply
Clin Chem 2006 52: 154-155. [Extract] [Full Text] [PDF]  

Goce Dimeski, Peter Mollee, and Andrew Carter

Effects of Hyperlipidemia on Plasma Sodium, Potassium, and Chloride Measurements by an Indirect Ion-Selective Electrode Measuring System
Clin Chem 2006 52: 155-156. [Extract] [Full Text] [PDF] Data Supplements  

Olav Lapaire, Helene Stroh, Inga Peter, Janet M. Cowan, Uma Tantravahi, Barbara O’Brien, Diana W. Bianchi, and Kirby L. Johnson

Larger Columns and Change of Lysis Buffer Increase the Yield of Cell-Free DNA Extracted from Amniotic Fluid
Clin Chem 2006 52: 156-157. [Extract] [Full Text] [PDF]  

L. Thomas Vlasveld, Jan W. van’t Wout, Peter Meeuwissen, and Ad Castel

High Measured Cobalamin (Vitamin B₁₂) Concentration Attributable to an Analytical Problem in Testing Serum from a Patient with Pernicious Anemia
Clin Chem 2006 52: 157-158. [Extract] [Full Text] [PDF]  

Kathy Maugh

High Measured Cobalamin (Vitamin B₁₂) Concentration Attributable to an Analytical Problem in Testing Serum from a Patient with Pernicious Anemia: Reply
Clin Chem 2006 52: 158-159. [Extract] [Full Text] [PDF]  

Ronit Haimov-Kochman, Susan J. Fisher, and Virginia D. Winn

Modification of the Standard Trizol-Based Technique Improves the Integrity of RNA Isolated from RNase-Rich Placental Tissue
Clin Chem 2006 52: 159-160. [Extract] [Full Text] [PDF] Supplemental Data  

Terrence W. Hallahan, David A. Krantz, V. James Macri, and Thomas J. Shine

First-Trimester Down Syndrome Screening
Clin Chem 2006 52: 160-161. [Extract] [Full Text] [PDF]  

Glenn E. Palomaki, George J. Knight, Louis M. Neveux, James E. Haddow, and Raj Pandian

First-Trimester Down Syndrome Screening: Reply
Clin Chem 2006 52: 161. [Extract] [Full Text] [PDF]  

Book, Software, and Web Site Reviews:

Helen Savoia

Textbook of Blood Banking and Transfusion Medicine, Second Edition. Sally V. Rudman, editor. Philadelphia, PA: Elsevier Saunders, 2005, 686 pp., $59.95, hardcover. ISBN 0-7216-0384-X.
Clin Chem 2006 52: 162. [Extract] [Full Text] [PDF]  

Helen Savoia

Transfusion Therapy: Clinical Principles and Practice, 2nd Edition. Paul D. Mintz, editor. Bethesda, MD: AABB Press, 2005, 690 pp., $185.00, hardcover. ISBN 1-56395-185-1.
Clin Chem 2006 52: 162-163. [Extract] [Full Text] [PDF]  

Lawrence Silverman

Referenced Review Questions in Molecular Medicine. Robert M. White, Sr., David W. Brown, and Steven A. Williams. Washington, DC: AACC Press, 2005, 235 pp., $49.00 ($39.00 AACC members), softcover. ISBN 1-594250-33-2.
Clin Chem 2006 52: 163. [Extract] [Full Text] [PDF]  

Parvin P. Waymack

Clinical Diagnostic Technology: The Total Testing Process. Volume 2: The Analytical Phase. Kory M. Ward-Cook, Craig A. Lehmann, Larry E. Schoeff, and Robert H. Williams, editors. Washington, DC: AACC Press, 2005, 450 pp., $89.00 ($71.00 AACC members), softcover. ISBN 1-594250-34-0.
Clin Chem 2006 52: 163-164. [Extract] [Full Text] [PDF]  

Invited Reviewers:

Invited Reviewers—2005
Clin Chem 2006 52: 165-168. [Extract] [Full Text] [PDF]  

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