Editorials:

D. Robert Dufour

Hepatitis B Surface Antigen (HBsAg) Assays—Are They Good Enough for Their Current Uses?
Clin Chem 2006 52: 1457-1459. [Extract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Trine Ranheim, Mari Ann Kulseth, Knut Erik Berge, and Trond Paul Leren

Model System for Phenotypic Characterization of Sequence Variations in the LDL Receptor Gene
Clin Chem 2006 52: 1469-1479. Published online June 1, 2006; 10.1373/clinchem.2006.068627 [Abstract] [Full Text] [PDF]  

Miguel de la Hoya, Sara Gutiérrez-Enríquez, Eladio Velasco, Ana Osorio, Ana Sanchez de Abajo, Ana Vega, Raquel Salazar, Eva Esteban, Gemma Llort, Rogelio Gonzalez-Sarmiento, Angel Carracedo, Javier Benítez, Cristina Miner, Orland Díez, Eduardo Díaz-Rubio, and Trinidad Caldes

Genomic Rearrangements at the BRCA1 Locus in Spanish Families with Breast/Ovarian Cancer
Clin Chem 2006 52: 1480-1485. Published online June 22, 2006; 10.1373/clinchem.2006.070110 [Abstract] [Full Text] [PDF]  

Dar-Fu Tai, Chung-Yin Lin, Tzong-Zeng Wu, Jyh-Hsiung Huang, and Pei-Yun Shu

Artificial Receptors in Serologic Tests for the Early Diagnosis of Dengue Virus Infection
Clin Chem 2006 52: 1486-1491. Published online June 15, 2006; 10.1373/clinchem.2005.064501 [Abstract] [Full Text] [PDF] 064501.Supplemental Data  

Youyou Zhou, Josephine M.S. Lum, Gare-Hoon Yeo, Jennifer Kiing, Stacey K.H. Tay, and Samuel S. Chong

Simplified Molecular Diagnosis of Fragile X Syndrome by Fluorescent Methylation-Specific PCR and GeneScan Analysis
Clin Chem 2006 52: 1492-1500. Published online June 22, 2006; 10.1373/clinchem.2006.068593 [Abstract] [Full Text] [PDF]  

Automation and Analytical Techniques:

Sheila A.R. Kort, Frans Martens, Hilde Vanpoucke, Hans L. van Duijnhoven, and Marinus A. Blankenstein

Comparison of 6 Automated Assays for Total and Free Prostate-Specific Antigen with Special Reference to Their Reactivity toward the WHO 96/670 Reference Preparation
Clin Chem 2006 52: 1568-1574. Published online June 8, 2006; 10.1373/clinchem.2006.069039 [Abstract] [Full Text] [PDF] 069039.Supplemental Data  

Lars Toellner, Martin Fischlechner, Boris Ferko, Reingard Maria Grabherr, and Edwin Donath

Virus-Coated Layer-by-Layer Colloids as a Multiplex Suspension Array for the Detection and Quantification of Virus-Specific Antibodies
Clin Chem 2006 52: 1575-1583. Published online May 25, 2006; 10.1373/clinchem.2005.065789 [Abstract] [Full Text] [PDF]  

Lipids, Lipoproteins, and Cardiovascular Risk Factors:

Lennart Nilsson, Lena Jonasson, Johnny Nijm, Anders Hamsten, and Per Eriksson

Increased Plasma Concentration of Matrix Metalloproteinase-7 in Patients with Coronary Artery Disease
Clin Chem 2006 52: 1522-1527. Published online June 8, 2006; 10.1373/clinchem.2006.067439 [Abstract] [Full Text] [PDF]  

Serge Masson, Roberto Latini, Inder S. Anand, Tarcisio Vago, Laura Angelici, Simona Barlera, Emil D. Missov, Aldo Clerico, Gianni Tognoni, Jay N. Cohn on behalf of the Val-HeFT Investigators

Direct Comparison of B-Type Natriuretic Peptide (BNP) and Amino-Terminal proBNP in a Large Population of Patients with Chronic and Symptomatic Heart Failure: The Valsartan Heart Failure (Val-HeFT) Data
Clin Chem 2006 52: 1528-1538. Published online June 15, 2006; 10.1373/clinchem.2006.069575 [Abstract] [Full Text] [PDF]  

Proteomics and Protein Markers:

Judith M. de Bont, Monique L. den Boer, Roel E. Reddingius, Jaap Jansen, Monique Passier, Ron H.N. van Schaik, Johan M. Kros, Peter A.E. Sillevis Smitt, Theo H. Luider, and Rob Pieters

Identification of Apolipoprotein A-II in Cerebrospinal Fluid of Pediatric Brain Tumor Patients by Protein Expression Profiling
Clin Chem 2006 52: 1501-1509. Published online June 8, 2006; 10.1373/clinchem.2006.069294 [Abstract] [Full Text] [PDF] 069294.Supplemental data  

Sun-Young Kong, Byung-Ho Nam, Keun Seok Lee, Youngmee Kwon, Eun Sook Lee, Moon-Woo Seong, Do Hoon Lee, and Jungsil Ro

Predicting Tissue HER2 Status Using Serum HER2 Levels in Patients with Metastatic Breast Cancer
Clin Chem 2006 52: 1510-1515. Published online June 15, 2006; 10.1373/clinchem.2006.067512 [Abstract] [Full Text] [PDF]  

Pasquale Florio, Serafina Perrone, Stefano Luisi, Piero Vezzosi, Mariangela Longini, Barbara Marzocchi, Felice Petraglia, and Giuseppe Buonocore

Increased Plasma Concentrations of Activin A Predict Intraventricular Hemorrhage in Preterm Newborns
Clin Chem 2006 52: 1516-1521. Published online June 1, 2006; 10.1373/clinchem.2005.065979 [Abstract] [Full Text] [PDF]  

Drug Monitoring and Toxicology:

Ming Li, Cheuk Man Yu, Lei Cheng, Mei Wang, Xuemei Gu, Ka Ho Lee, Tian Wang, Yn Tz Sung, and John E. Sanderson

Repair of Infarcted Myocardium by an Extract of Geum japonicum with Dual Effects on Angiogenesis and Myogenesis
Clin Chem 2006 52: 1460-1468. Published online June 22, 2006; 10.1373/clinchem.2006.068247 [Abstract] [Full Text] [PDF]  

Eugene W. Schwilke, Allan J. Barnes, Sherri L. Kacinko, Edward J. Cone, Eric T. Moolchan, and Marilyn A. Huestis

Opioid Disposition in Human Sweat after Controlled Oral Codeine Administration
Clin Chem 2006 52: 1539-1545. Published online June 1, 2006; 10.1373/clinchem.2006.067983 [Abstract] [Full Text] [PDF] 067983.Supplemental Data  

Endocrinology and Metabolism:

Margrita H. Slagter, Andreas Scorilas, Louis J.G. Gooren, Willem de Ronde, Antoninus Soosaipillai, Erik J. Giltay, Miltiadis Paliouras, and Eleftherios P. Diamandis

Effect of Testosterone Administration on Serum and Urine Kallikrein Concentrations in Female-to-Male Transsexuals
Clin Chem 2006 52: 1546-1551. Published online June 15, 2006; 10.1373/clinchem.2006.067041 [Abstract] [Full Text] [PDF]  

Pierre-Alexandre Krayenbuehl, Friedrich E. Maly, Martin Hersberger, Peter Wiesli, Andreas Himmelmann, Karim Eid, Peter Greminger, Wilhelm Vetter, and Georg Schulthess

Tumor Necrosis Factor- –308G>A Allelic Variant Modulates Iron Accumulation in Patients with Hereditary Hemochromatosis
Clin Chem 2006 52: 1552-1558. Published online June 22, 2006; 10.1373/clinchem.2005.065417 [Abstract] [Full Text] [PDF]  

Mark M. Kushnir, Alan L. Rockwood, William L. Roberts, Elizabeth G. Pattison, William E. Owen, Ashley M. Bunker, and A. Wayne Meikle

Development and Performance Evaluation of a Tandem Mass Spectrometry Assay for 4 Adrenal Steroids
Clin Chem 2006 52: 1559-1567. Published online June 15, 2006; 10.1373/clinchem.2006.068445 [Abstract] [Full Text] [PDF] 068445.Supplemental Data  

Laboratory Management:

Simon C. Ramsden, Sarah Daly, Wolf-Jochen Geilenkeuser, Graeme Duncan, Fabienne Hermitte, Ettore Marubini, Michael Neumaier, Claudio Orlando, Vladimir Palicka, Angelo Paradiso, Mario Pazzagli, Sara Pizzamiglio, and Paolo Verderio

EQUAL-quant: An International External Quality Assessment Scheme for Real-Time PCR
Clin Chem 2006 52: 1584-1591. Published online June 1, 2006; 10.1373/clinchem.2005.066019 [Abstract] [Full Text] [PDF] 066019.Supplemental Data  

Other Areas of Clinical Chemistry:

Dan Chen and Lawrence A. Kaplan

Performance of a New-Generation Chemiluminescent Assay for Hepatitis B Surface Antigen
Clin Chem 2006 52: 1592-1598. Published online June 8, 2006; 10.1373/clinchem.2005.064063 [Abstract] [Full Text] [PDF]  

Technical Briefs:

Levente Lázár, Bálint Nagy, Zoltán Bán, Gyula R Nagy, and Zoltán Papp

Presence of Cell-Free Fetal DNA in Plasma of Women with Ectopic Pregnancies,
Clin Chem 2006 52: 1599-1601. Published online June 1, 2006; 10.1373/clinchem.2006.067587 [Abstract] [Full Text] [PDF]  

Letters to the Editor:

M. Rebecca Fokkema, Zuzana Herrmann, Frits A.J. Muskiet, and Joachim Moecks

Reference Change Values for Brain Natriuretic Peptides Revisited
Clin Chem 2006 52: 1602-1603. [Extract] [Full Text] [PDF]  

Mary O. Carayannopoulos, Timothy R. Wilhite, Lakshmi Reddy, Michael Landt, Carl H. Smith, and Dennis J. Dietzen

Equimolar Ammonia Interference in Potassium Measurement on the Osmetech OPTI Critical Care Analyzer
Clin Chem 2006 52: 1603-1604. [Extract] [Full Text] [PDF]  

Femke H. Bouwman, Wiesje M. van der Flier, Niki S.M. Schoonenboom, Evert J. van Elk, Astrid Kok, Philip Scheltens, and Marinus A. Blankenstein

Usefulness of Longitudinal Measurements of ß-Amyloid_1–42 in Cerebrospinal Fluid of Patients with Various Cognitive and Neurologic Disorders
Clin Chem 2006 52: 1604-1606. [Extract] [Full Text] [PDF] 070193.Supplemental Data  

Daniel T. Holmes and Kevin Buhr

Mathematical Modeling: Assumptions Affect Results
Clin Chem 2006 52: 1606-1608. [Extract] [Full Text] [PDF]  

Curtis A. Parvin and Fred S. Apple

The authors of the article cited above respond:
Clin Chem 2006 52: 1608-1609. [Extract] [Full Text] [PDF]  

Mieke Develter, Norbert Blanckaert, Arnost Komárek, and Xavier Bossuyt

Can Heparin Plasma Be Used instead of Serum for Nephelometric Analysis of Serum Proteins?
Clin Chem 2006 52: 1609-1610. [Extract] [Full Text] [PDF]  

Arnab Gupta, Poonam Nasipuri, Shyamal K. Das, and Kunal Ray

Simple and Effective Strategies for Detection of Allele Dropout in PCR-Based Diagnosis of Wilson Disease
Clin Chem 2006 52: 1611-1612. [Extract] [Full Text] [PDF] 069989.Supplemental Data  

Goce Dimeski and Andrew Carter

Magnesium Contamination from Terumo Blood Collection Tubes
Clin Chem 2006 52: 1612-1614. [Extract] [Full Text] [PDF]  

Mauro Negri and Claudia Lo Cascio

Use of Lowercase "p" or Uppercase "P" to Express Blood Gas Data: Does It Make a Difference?
Clin Chem 2006 52: 1614. [Extract] [Full Text] [PDF]  

Olaf Schulz, Katrin Kirpal, Julia Stein, Ricarda Bensch, Gunnar Berghöfer, Ingolf Schimke, and Allan S. Jaffe

Importance of Low Concentrations of Cardiac Troponins
Clin Chem 2006 52: 1614-1615. [Extract] [Full Text] [PDF]  

Rhys John

Response to Newman et al. (March 2006): Factitious Increase in Thyrotropin in a Neonate Caused by a Maternally Transmitted Interfering Substance
Clin Chem 2006 52: 1615-1616. [Extract] [Full Text] [PDF]  

Tze-Kiong Er, Yuh-Jyh Jong, Eing-Mei Tsai, Chi-Lin Huang, Hui-Wen Chou, Bing-Hong Zheng, and Li-Yu Tsai

False-Negative Pregnancy Test in Hydatidiform Mole
Clin Chem 2006 52: 1616-1618. [Extract] [Full Text] [PDF]  

Julie Gonin, Sophie Dreux, Fabien Guimiot, Françoise Menez, Jean Guibourdenche, Daniel Biou, and Françoise Muller

Neural Tube Defects Cannot Be Diagnosed Prenatally by Electrophoresis of Amniotic Fluid Transferrin Isoforms
Clin Chem 2006 52: 1618-1619. [Extract] [Full Text] [PDF]  

Salim Fredericks, Vicente Bertomeu-Gonzalez, Ivana Petrovic, David W. Holt, and Juan Carlos Kaski

Comment on Immunoassays Developed for Pregnancy-Associated Plasma Protein-A (PAPP-A) in Pregnancy May Not Recognize PAPP-A in Acute Coronary Syndromes
Clin Chem 2006 52: 1619-1620. [Extract] [Full Text] [PDF]  

Catherine Costa, Michel Goossens, and Emmanuelle Girodon

Simultaneous Molecular Haplotyping of Both IVS8 (TG)_m and (T)_n Tracts in the CFTR Gene: Still a Challenge
Clin Chem 2006 52: 1621-1622. [Extract] [Full Text] [PDF]  

Alison Millson, Genevieve Pont-Kingdon, and Elaine Lyon

Response to the letter "Simultaneous Molecular Haplotyping of Both IVS8 (TG)_m and (T)_n Tracts in the CFTR Gene: Still a Challenge" by Costa et al.
Clin Chem 2006 52: 1622. [Extract] [Full Text] [PDF]  

Milagros Blanco and Carmen Varela

Interference from Heterophilic Antibodies in the Olympus Ferritin Method
Clin Chem 2006 52: 1623-1624. [Extract] [Full Text] [PDF]  

Renze Bais

What Information Should Manufacturers Provide on Their Procedures?
Clin Chem 2006 52: 1624-1625. [Extract] [Full Text] [PDF]  

Olga Scudiero, Gerardo Nardone, Daniela Omodei, Fabiana Tatangelo, Dino Franco Vitale, Francesco Salvatore, and Giuseppe Castaldo

A Mannose-Binding Lectin-Defective Haplotype Is a Risk Factor for Gastric Cancer
Clin Chem 2006 52: 1625-1627. [Extract] [Full Text] [PDF]  

Ana K. Stankovic and Girish Parmar

Assay Interferences from Blood Collection Tubes: A Cautionary Note
Clin Chem 2006 52: 1627-1628. [Extract] [Full Text] [PDF]  

Book, Software, and Web Site Reviews:

Larry J. Kricka

Won for All: How the Drosophila Genome Was Sequenced. Michael Ashburner. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 2006, 107 pp., $19.95, hardcover. ISBN 0-87969-802-0.
Clin Chem 2006 52: 1629. [Extract] [Full Text] [PDF]  

Hansotto Reiber

Proteins of the Cerebrospinal Fluid: Analysis and Interpretation in the Diagnosis and Treatment of Neurological Disease, Second Edition. Edward J. Thompson. London: Elsevier Academic Press, 2005, 332 pp., $149.95, hardcover. ISBN 0-12-369369-1.
Clin Chem 2006 52: 1629-1630. [Extract] [Full Text] [PDF]  

David M. Goldberg

Resveratrol in Health and Disease. B. Aggarwal and S. Shishodia, eds. Boca Raton, FL: CRC Press, Taylor & Francis Group, 2006, 712 pp., $199.95, hardcover. ISBN 0-8493-3371-7.
Clin Chem 2006 52: 1630. [Extract] [Full Text] [PDF]  

Corrections:

Correction
Clin Chem 2006 52: 1628. [Extract] [Full Text] [PDF]  

Correction
Clin Chem 2006 52: 1628. [Extract] [Full Text] [PDF]  

Correction
Clin Chem 2006 52: 1628. [Extract] [Full Text] [PDF]  

The Clinical Chemist:

Robert E. Emmons Compiled by David E. Bruns Editor

Animal Clinical Chemistry Division Celebrates 30th Anniversary with the American Association for Clinical Chemistry
Clin Chem 2006 52: 1631-1632. [Extract] [Full Text] [PDF]  

Ranking of Medical Shows in the United States
Clin Chem 2006 52: 1632. [Extract] [Full Text] [PDF]  

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