Editorials:

Glen L. Hortin

A New Era in Protein Quantification in Clinical Laboratories: Application of Liquid Chromatography-Tandem Mass Spectrometry
Clin Chem 2007 53: 543-544. [Extract] [Full Text] [PDF]  

Current Issues in Laboratory Medicine:

Curtis A. Parvin and Sanford Robbins, III

Evaluation of the Performance of Randomized versus Fixed Time Schedules for Quality Control Procedures
Clin Chem 2007 53: 575-580. Published online February 22, 2007; 10.1373/clinchem.2006.083311 [Abstract] [Full Text] [PDF] 083311.Supplemental Data  

Proteomics and Protein Markers:

Erwin H.J.M. Kemna, Harold Tjalsma, Vladimir N. Podust, and Dorine W. Swinkels

Mass Spectrometry–Based Hepcidin Measurements in Serum and Urine: Analytical Aspects and Clinical Implications
Clin Chem 2007 53: 620-628. Published online February 1, 2007; 10.1373/clinchem.2006.079186 [Abstract] [Full Text] [PDF] 079186.Supplemental Data  

Christian Melle, Günther Ernst, Niko Escher, Daniel Hartmann, Bettina Schimmel, Annett Bleul, Heike Thieme, Roland Kaufmann, Klaus Felix, Helmut M. Friess, Utz Settmacher, Merten Hommann, Konrad K. Richter, Wolfgang Daffner, Horst Täubig, Thomas Manger, Uwe Claussen, and Ferdinand von Eggeling

Protein Profiling of Microdissected Pancreas Carcinoma and Identification of HSP27 as a Potential Serum Marker
Clin Chem 2007 53: 629-635. Published online February 15, 2007; 10.1373/clinchem.2006.079194 [Abstract] [Full Text] [PDF] 079194.Supplemental Data  

Amelie Plymoth, Claes-Göran Löfdahl, Ann Ekberg-Jansson, Magnus Dahlbäck, Per Broberg, Martyn Foster, Thomas E. Fehniger, and György Marko-Varga

Protein Expression Patterns Associated with Progression of Chronic Obstructive Pulmonary Disease in Bronchoalveolar Lavage of Smokers
Clin Chem 2007 53: 636-644. Published online February 15, 2007; 10.1373/clinchem.2006.076075 [Abstract] [Full Text] [PDF] 076075.Supplemental Data  

John F. Timms, Elif Arslan-Low, Aleksandra Gentry-Maharaj, Zhiyuan Luo, Davy T’Jampens, Vladimir N. Podust, Jeremy Ford, Eric T. Fung, Alex Gammerman, Ian Jacobs, and Usha Menon

Preanalytic Influence of Sample Handling on SELDI-TOF Serum Protein Profiles
Clin Chem 2007 53: 645-656. Published online February 15, 2007; 10.1373/clinchem.2006.080101 [Abstract] [Full Text] [PDF] 080101.Supplemental Data  

Minna A. Korolainen, Tuula A. Nyman, Paula Nyyssönen, E. Samuel Hartikainen, and Tuula Pirttilä

Multiplexed Proteomic Analysis of Oxidation and Concentrations of Cerebrospinal Fluid Proteins in Alzheimer Disease
Clin Chem 2007 53: 657-665. Published online February 8, 2007; 10.1373/clinchem.2006.078014 [Abstract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Peng Hou, Zaozao Chen, Meiju Ji, Nongyue He, and Zuhong Lu

Real-time PCR Assay for Ultrasensitive Quantification of DNA-Binding Proteins
Clin Chem 2007 53: 581-586. Published online February 8, 2007; 10.1373/clinchem.2006.077503 [Abstract] [Full Text] [PDF] 077503.Supplemental Data  

Claudia Langebrake, Kalle Günther, Jürgen Lauber, and Dirk Reinhardt

Preanalytical mRNA Stabilization of Whole Bone Marrow Samples
Clin Chem 2007 53: 587-593. Published online February 8, 2007; 10.1373/clinchem.2006.078592 [Abstract] [Full Text] [PDF]  

Constance L.H. Lo, Shea Ping Yip, Peter K.C. Cheng, Tony S.S. To, Wilina W.L. Lim, and Polly H.M. Leung

One-Step Rapid Reverse Transcription–PCR Assay for Detecting and Typing Dengue Viruses with GC Tail and Induced Fluorescence Resonance Energy Transfer Techniques for Melting Temperature and Color Multiplexing
Clin Chem 2007 53: 594-599. Published online February 22, 2007; 10.1373/clinchem.2006.077446 [Abstract] [Full Text] [PDF] 077446.Supplemental Data  

Wolfgang Lalouschek, Georg Endler, Martin Schillinger, Kety Hsieh, Wilfried Lang, Suzanne Cheng, Peter Bauer, Oswald Wagner, and Christine Mannhalter

Candidate Genetic Risk Factors of Stroke: Results of a Multilocus Genotyping Assay
Clin Chem 2007 53: 600-605. Published online February 22, 2007; 10.1373/clinchem.2006.073494 [Abstract] [Full Text] [PDF] 073494.Supplemental Data  

Natale Scaramozzino, Audrey Ferrier-Rembert, Anne-laure Favier, Corinne Rothlisberger, Stéphane Richard, Jean-Marc Crance, Hermann Meyer, and Daniel Garin

Real-Time PCR to Identify Variola Virus or Other Human Pathogenic Orthopox Viruses
Clin Chem 2007 53: 606-613. Published online March 1, 2007; 10.1373/clinchem.2006.068635 [Abstract] [Full Text] [PDF]  

Automation and Analytical Techniques:

John Middleton and Jeffrey E. Vaks

Evaluation of Assigned-Value Uncertainty for Complex Calibrator Value Assignment Processes: A Prealbumin Example
Clin Chem 2007 53: 735-741. Published online February 15, 2007; 10.1373/clinchem.2006.081174 [Abstract] [Full Text] [PDF] 081174.Supplemental Data  

Johanna E.M. Groener, Ben J.H.M. Poorthuis, Sijmen Kuiper, Mariette T.J. Helmond, Carla E.M. Hollak, and Johannes M.F.G. Aerts

HPLC for Simultaneous Quantification of Total Ceramide, Glucosylceramide, and Ceramide Trihexoside Concentrations in Plasma
Clin Chem 2007 53: 742-747. Published online March 1, 2007; 10.1373/clinchem.2006.079012 [Abstract] [Full Text] [PDF]  

Duncan C.S. Talbot, Richard M. Ogborne, Tony Dadd, Herman Adlercreutz, Geoff Barnard, Susanne Bugel, Fortune Kohen, Sandra Marlin, Jerry Piron, Aedin Cassidy, and Jonathan Powell

Monoclonal Antibody-Based Time-Resolved Fluorescence Immunoassays for Daidzein, Genistein, and Equol in Blood and Urine: Application to the Isoheart Intervention Study
Clin Chem 2007 53: 748-756. Published online February 22, 2007; 10.1373/clinchem.2006.075077 [Abstract] [Full Text] [PDF]  

Lipids, Lipoproteins, and Cardiovascular Risk Factors:

Gregory T. Jones, Andre M. van Rij, Jennifer Cole, Michael J.A. Williams, Emma H. Bateman, Santica M. Marcovina, Meiying Deng, and Sally P.A. McCormick

Plasma Lipoprotein(a) Indicates Risk for 4 Distinct Forms of Vascular Disease
Clin Chem 2007 53: 679-685. Published online February 15, 2007; 10.1373/clinchem.2006.079947 [Abstract] [Full Text] [PDF] 079947.Supplemental Data  

Yoosoo Chang, Seungho Ryu, Eunju Sung, and Yumi Jang

Higher Concentrations of Alanine Aminotransferase within the Reference Interval Predict Nonalcoholic Fatty Liver Disease
Clin Chem 2007 53: 686-692. Published online February 1, 2007; 10.1373/clinchem.2006.081257 [Abstract] [Full Text] [PDF]  

Renke Maas, Friedrich Schulze, Jens Baumert, Hannelore Löwel, Khatera Hamraz, Edzard Schwedhelm, Wolfgang Koenig, and Rainer H. Böger

Asymmetric Dimethylarginine, Smoking, and Risk of Coronary Heart Disease in Apparently Healthy Men: Prospective Analysis from the Population-Based Monitoring of Trends and Determinants in Cardiovascular Disease/Kooperative Gesundheitsforschung in der Region Augsburg Study and Experimental Data
Clin Chem 2007 53: 693-701. Published online February 22, 2007; 10.1373/clinchem.2006.081893 [Abstract] [Full Text] [PDF]  

Drug Monitoring and Toxicology:

Frank T. Peters, Nele Samyn, Thomas Kraemer, Wim J. Riedel, and Hans H. Maurer

Negative-Ion Chemical Ionization Gas Chromatography–Mass Spectrometry Assay for Enantioselective Measurement of Amphetamines in Oral Fluid: Application to a Controlled Study with MDMA and Driving Under the Influence Cases
Clin Chem 2007 53: 702-710. Published online March 1, 2007; 10.1373/clinchem.2006.081547 [Abstract] [Full Text] [PDF] 081547.Supplemental data  

Evidence-Based Laboratory Medicine and Test Utilization:

Robert H. Christenson

National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines for Utilization of Biochemical Markers in Acute Coronary Syndromes and Heart Failure
Clin Chem 2007 53: 545-546. Published online March 23, 2007; 10.1373/clinchem.2006.079749 [Extract] [Full Text] [PDF] Financial Disclosures  

NACB WRITING GROUP MEMBERS, Fred S. Apple, Robert L. Jesse, L. Kristin Newby, Alan H.B. Wu, Robert H. Christenson, NACB COMMITTEE MEMBERS, Robert H. Christenson, Fred S. Apple, Christopher P. Cannon, Gary Francis, Robert Jesse, David A. Morrow, L. Kristin Newby, Jan Ravkilde, Alan B. Storrow, Wilson Tang, Alan H.B. Wu, IFCC COMMITTEE ON STANDARDIZATION OF MARKERS OF CARDIAC DAMAGE (C-SMCD) MEMBERS, Fred S. Apple, Robert H. Christenson, Allan S. Jaffe, Johannes Mair, Jordi Ordonez-Llanos, Franca Pagani, Mauro Panteghini, Jillian Tate, and Alan H.B. Wu

National Academy of Clinical Biochemistry and IFCC Committee for Standardization of Markers of Cardiac Damage Laboratory Medicine Practice Guidelines: Analytical Issues for Biochemical Markers of Acute Coronary Syndromes
Clin Chem 2007 53: 547-551. Published online March 23, 2007; 10.1373/clinchem.2006.084715 [Extract] [Full Text] [PDF] Financial Disclosures  

NACB WRITING GROUP MEMBERS, David A. Morrow, Christopher P. Cannon, Robert L. Jesse, L. Kristin Newby, Jan Ravkilde, Alan B. Storrow, Alan H.B. Wu, Robert H. Christenson, NACB COMMITTEE MEMBERS, Robert H. Christenson, Fred S. Apple, Christopher P. Cannon, Gary Francis, Robert L. Jesse, David A. Morrow, L. Kristin Newby, Jan Ravkilde, Alan B. Storrow, Wilson Tang, and Alan H.B. Wu

National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: Clinical Characteristics and Utilization of Biochemical Markers in Acute Coronary Syndromes
Clin Chem 2007 53: 552-574. Published online March 23, 2007; 10.1373/clinchem.2006.084194 [Extract] [Full Text] [PDF] Financial Disclosures  

Hemostasis and Thrombosis:

Boris T. Ivandic, Evangelos Giannitsis, Philipp Schlick, Peter Staritz, Hugo A. Katus, and Thomas Hohlfeld

Determination of Aspirin Responsiveness by Use of Whole Blood Platelet Aggregometry
Clin Chem 2007 53: 614-619. Published online March 1, 2007; 10.1373/clinchem.2006.081059 [Abstract] [Full Text] [PDF]  

Cancer Diagnostics:

Heather L. Beyer, Ryan D. Geschwindt, Curtis L. Glover, Ly Tran, Ingegerd Hellstrom, Karl-Erik Hellstrom, M. Craig Miller, Thorsten Verch, W. Jeffrey Allard, Harvey I. Pass, and Niranjan Y. Sardesai

MESOMARK^TM: A Potential Test for Malignant Pleural Mesothelioma
Clin Chem 2007 53: 666-672. Published online February 8, 2007; 10.1373/clinchem.2006.079327 [Abstract] [Full Text] [PDF] 079327.Supplemental Data  

Olga P. Bondar, David R. Barnidge, Eric W. Klee, Brian J. Davis, and George G. Klee

LC-MS/MS Quantification of Zn-2 Glycoprotein: A Potential Serum Biomarker for Prostate Cancer
Clin Chem 2007 53: 673-678. Published online February 22, 2007; 10.1373/clinchem.2006.079681 [Abstract] [Full Text] [PDF] 079681.Supplemental Data  

Endocrinology and Metabolism:

Santica Marcovina, Ronald R. Bowsher, W. Greg Miller, Myrlene Staten, Gary Myers, Samuel P. Caudill, Scott E. Campbell, Michael W. Steffes for the Insulin Standardization Workgroup

Standardization of Insulin Immunoassays: Report of the American Diabetes Association Workgroup
Clin Chem 2007 53: 711-716. Published online February 1, 2007; 10.1373/clinchem.2006.082214 [Abstract] [Full Text] [PDF] Data Supplement  

Kristina Anna Strnadová, Margareta Holub, Adolf Mühl, Georg Heinze, Rene Ratschmann, Hermann Mascher, Sylvia Stöckler-Ipsiroglu, Franz Waldhauser, Felix Votava, Jan Lebl, and Olaf A. Bodamer

Long-Term Stability of Amino Acids and Acylcarnitines in Dried Blood Spots
Clin Chem 2007 53: 717-722. Published online February 1, 2007; 10.1373/clinchem.2006.076679 [Abstract] [Full Text] [PDF] 076679.Supplemental Data  

Henri Déchaud, Anne Denuzière, Sabina Rinaldi, Julien Bocquet, Hervé Lejeune, and Michel Pugeat

Age-Associated Discrepancy between Measured and Calculated Bioavailable Testosterone in Men
Clin Chem 2007 53: 723-728. Published online February 22, 2007; 10.1373/clinchem.2006.077362 [Abstract] [Full Text] [PDF]  

Antoon J.M. Janssen, Frans J.M. Trijbels, Rob C.A. Sengers, Jan A.M. Smeitink, Lambert P. van den Heuvel, Liesbeth T.M. Wintjes, Berendien J.M. Stoltenborg-Hogenkamp, and Richard J.T. Rodenburg

Spectrophotometric Assay for Complex I of the Respiratory Chain in Tissue Samples and Cultured Fibroblasts
Clin Chem 2007 53: 729-734. Published online March 1, 2007; 10.1373/clinchem.2006.078873 [Abstract] [Full Text] [PDF] 078873.Supplemental data  

Clinical Immunology:

Santosh K. Ghosh, Thomas A. Gerken, Keith M. Schneider, Zhimin Feng, Thomas S. McCormick, and Aaron Weinberg

Quantification of Human ß-Defensin-2 and -3 in Body Fluids: Application for Studies of Innate Immunity
Clin Chem 2007 53: 757-765. Published online February 22, 2007; 10.1373/clinchem.2006.081430 [Abstract] [Full Text] [PDF] 081430.Supplemental Data  

Other Areas of Clinical Chemistry:

Andrew S. Levey, Josef Coresh, Tom Greene, Jane Marsh, Lesley A. Stevens, John W. Kusek, Frederick Van Lente for Chronic Kidney Disease Epidemiology Collaboration

Expressing the Modification of Diet in Renal Disease Study Equation for Estimating Glomerular Filtration Rate with Standardized Serum Creatinine Values
Clin Chem 2007 53: 766-772. Published online March 1, 2007; 10.1373/clinchem.2006.077180 [Abstract] [Full Text] [PDF] Data Supplement  

Markus Herrmann, Omid Taban-Shoma, Ulrich Hübner, Anette Pexa, Heiko Kilter, Natalia Umanskaya, Rainer Hans Straub, Michael Böhm, and Wolfgang Herrmann

Hyperhomocysteinemia and Myocardial Expression of Brain Natriuretic Peptide in Rats
Clin Chem 2007 53: 773-780. Published online February 15, 2007; 10.1373/clinchem.2006.077859 [Abstract] [Full Text] [PDF] 077859.Supplemental Data  

Technical Briefs:

Zia Fazili, Christine M. Pfeiffer, and Mindy Zhang

Comparison of Serum Folate Species Analyzed by LC-MS/MS with Total Folate Measured by Microbiologic Assay and Bio-Rad Radioassay
Clin Chem 2007 53: 781-784. Published online February 1, 2007; 10.1373/clinchem.2006.078451 [Abstract] [Full Text] [PDF] 078451.Supplemental Data  

Hsiao-Mei Wiedmeyer, Kenneth S. Polonsky, Gary L. Myers, Randie R. Little, Carla J. Greenbaum, David E. Goldstein, and Jerry P. Palmer

International Comparison of C-Peptide Measurements
Clin Chem 2007 53: 784-787. Published online March 1, 2007; 10.1373/clinchem.2006.081570 [Abstract] [Full Text] [PDF]  

Ulrike Haug, Timo Hillebrand, Peter Bendzko, Michael Löw, Dietrich Rothenbacher, Christa Stegmaier, and Hermann Brenner

Mutant-Enriched PCR and Allele-Specific Hybridization Reaction to Detect K-ras Mutations in Stool DNA: High Prevalence in a Large Sample of Older Adults
Clin Chem 2007 53: 787-790. Published online February 22, 2007; 10.1373/clinchem.2006.078188 [Abstract] [Full Text] [PDF]  

Christina Dahl, Karen Grønskov, Lars A. Larsen, Per Guldberg, and Karen Brøndum-Nielsen

A Homogeneous Assay for Analysis of FMR1 Promoter Methylation in Patients with Fragile X Syndrome
Clin Chem 2007 53: 790-793. Published online January 26, 2007; 10.1373/clinchem.2006.080762 [Abstract] [Full Text] [PDF]  

Book, Software, and Web Site Reviews:

Roland Valdes, Jr

An A-Z Guide to Pharmacogenomics. Michael G. Catania. Washington DC: AACC Press, 2006, 58 pp., $24 ($19 AACC members), softcover. ISBN 1-59425-047-2.
Clin Chem 2007 53: 806. [Extract] [Full Text] [PDF]  

Emily S. Winn-Deen

Pharmacogenomics, Second Edition. Werner Kalow, Urs B. Meyer, and Rachel F. Tyndale, eds. Boca Raton, FL: Taylor & Francis Group, 2005, 696 pp., $199.95, hardcover. ISNB 1-57444-878-1.
Clin Chem 2007 53: 806. [Extract] [Full Text] [PDF]  

Corrections:

Correction
Clin Chem 2007 53: 805. [Extract] [Full Text] [PDF]  

Letters to the Editor:

Birger Mensel, Ulrike Wenzel, Markus Roser, Jan Lüdemann, and Matthias Nauck

Considerably Reduced Centrifugation Time without Increased Hemolysis: Evaluation of the New BD Vacutainer® SST^TMII Advance
Clin Chem 2007 53: 794-795. [Extract] [Full Text] [PDF] 079582.Supplemental Data  

Helen L. Bailey and Emily M. Chan

Liposomal Amphotericin B Interferes with the Phosphorus Assay on the Synchron LX 20 Analyzer
Clin Chem 2007 53: 795-796. [Extract] [Full Text] [PDF]  

Fiona M.F. Lun, Rossa W.K. Chiu, Tak Y. Leung, Tse N. Leung, Tze K. Lau, and Y.M. Dennis Lo

Epigenetic Analysis of RASSF1A Gene in Cell-Free DNA in Amniotic Fluid
Clin Chem 2007 53: 796-798. [Extract] [Full Text] [PDF]  

Mariasilvia Tommasi and Silvia Raspanti

Comparison of Calcitonin Determinations by Polyclonal and Monoclonal IRMAs
Clin Chem 2007 53: 798-799. [Extract] [Full Text] [PDF]  

Stanley F. Lo, Bernadine Jendrzejczak, and Basil T. Doumas

Total or Neonatal Bilirubin Assays in the Vitros 5,1 FS: Hemoglobin Interference, Hemolysis, Icterus Index
Clin Chem 2007 53: 799-800. [Extract] [Full Text] [PDF]  

Geralyn Lambert-Messerlian, Christina Bandera, Elizabeth Eklund, Andrew Neuhauser, and Jacob Canick

Very High Inhibin A Concentration Attributed to Heterophilic Antibody Interference
Clin Chem 2007 53: 800-801. [Extract] [Full Text] [PDF]  

Sarah Molyneux, Michael Lever, Christopher Florkowski, and Peter George

Plasma Total Coenzyme Q₉ (CoQ₉) in the New Zealand Population: Reference Interval and Biological Variation
Clin Chem 2007 53: 802-803. [Extract] [Full Text] [PDF]  

Etienne Cavalier, Pierre Delanaye, Jean-Marie Krzesinski, and Jean-Paul Chapelle

Analytical Variation in Plasma Renin Activity: Implications for the Screening of Primary Aldosteronism
Clin Chem 2007 53: 803-804. [Extract] [Full Text] [PDF]  

Katherine Duxbury, Louise Gallagher, and Brian Keevil

The Impact of Simultaneous Measurement of Testosterone and Androstenedione in Women with Suspected Androgen Excess
Clin Chem 2007 53: 804-805. [Extract] [Full Text] [PDF]  

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