Editorials:

Per Magne Ueland and Robert Clarke

Homocysteine and Cardiovascular Risk: Considering the Evidence in the Context of Study Design, Folate Fortification, and Statistical Power
Clin Chem 2007 53: 807-809. [Extract] [Full Text] [PDF]  

Rémy Sapin

Insulin Immunoassays: Fast Approaching 50 Years of Existence and Still Calling for Standardization
Clin Chem 2007 53: 810-812. [Extract] [Full Text] [PDF]  

Review:

Aldo Clerico, Marianna Fontana, Luc Zyw, Claudio Passino, and Michele Emdin

Comparison of the Diagnostic Accuracy of Brain Natriuretic Peptide (BNP) and the N-Terminal Part of the Propeptide of BNP Immunoassays in Chronic and Acute Heart Failure: A Systematic Review
Clin Chem 2007 53: 813-822. Published online March 23, 2007; 10.1373/clinchem.2006.075713 [Abstract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Hong-Kee Lee, Lionel D. Lewis, Gregory J. Tsongalis, Bernard C. Schur, Paul J. Jannetto, Steven H. Wong, and Kiang-Teck J. Yeo

Validation of a CYP2D6 Genotyping Panel on the NanoChip Molecular Biology Workstation
Clin Chem 2007 53: 823-828. Published online March 15, 2007; 10.1373/clinchem.2006.081539 [Abstract] [Full Text] [PDF] 081539.Supplemental Data  

Doris Hendig, Marius Arndt, Christiane Szliska, Knut Kleesiek, and Christian Götting

SPP1 Promoter Polymorphisms: Identification of the First Modifier Gene for Pseudoxanthoma Elasticum
Clin Chem 2007 53: 829-836. Published online March 23, 2007; 10.1373/clinchem.2006.083675 [Abstract] [Full Text] [PDF] 083675.Supplemental Data  

Ingke Braren, Simon Blank, Henning Seismann, Susanne Deckers, Markus Ollert, Thomas Grunwald, and Edzard Spillner

Generation of Human Monoclonal Allergen-Specific IgE and IgG Antibodies from Synthetic Antibody Libraries
Clin Chem 2007 53: 837-844. Published online March 29, 2007; 10.1373/clinchem.2006.078360 [Abstract] [Full Text] [PDF] 078360.Supplemental Data  

Robert Y.L. Zee, Samia Mora, Suzanne Cheng, Henry A. Erlich, Klaus Lindpaintner, Nader Rifai, Julie E. Buring, and Paul M Ridker

Homocysteine, 5,10-Methylenetetrahydrofolate Reductase 677C>T Polymorphism, Nutrient Intake, and Incident Cardiovascular Disease in 24 968 Initially Healthy Women
Clin Chem 2007 53: 845-851. Published online March 1, 2007; 10.1373/clinchem.2006.083881 [Abstract] [Full Text] [PDF] 083881.Supplemental Data  

Proteomics and Protein Markers:

Jakob Albrethsen

Reproducibility in Protein Profiling by MALDI-TOF Mass Spectrometry
Clin Chem 2007 53: 852-858. Published online March 29, 2007; 10.1373/clinchem.2006.082644 [Abstract] [Full Text] [PDF]  

Thierry S.M. Reijn, Marcel Olde Rikkert, Wieneke J.A. van Geel, Danielle de Jong, and Marcel M. Verbeek

Diagnostic Accuracy of ELISA and xMAP Technology for Analysis of Amyloid ß₄₂ and Tau Proteins
Clin Chem 2007 53: 859-865. Published online March 29, 2007; 10.1373/clinchem.2006.081679 [Abstract] [Full Text] [PDF] 081679.Supplemental data  

Karina R. Seferian, Natalia N. Tamm, Alexander G. Semenov, Kadriya S. Mukharyamova, Anastasya A. Tolstaya, Ekaterina V. Koshkina, Andrei N. Kara, Mihail I. Krasnoselsky, Fred S. Apple, Tatiana V. Esakova, Vladimir L. Filatov, and Alexey G. Katrukha

The Brain Natriuretic Peptide (BNP) Precursor Is the Major Immunoreactive Form of BNP in Patients with Heart Failure
Clin Chem 2007 53: 866-873. Published online March 23, 2007; 10.1373/clinchem.2006.076141 [Abstract] [Full Text] [PDF]  

Fred S. Apple, Lesly A. Pearce, Adrine Chung, Ranka Ler, and MaryAnn M. Murakami

Multiple Biomarker Use for Detection of Adverse Events in Patients Presenting with Symptoms Suggestive of Acute Coronary Syndrome
Clin Chem 2007 53: 874-881. Published online March 23, 2007; 10.1373/clinchem.2006.080192 [Abstract] [Full Text] [PDF] 080192.Supplemental Data  

Lipids, Lipoproteins, and Cardiovascular Risk Factors:

Angela Yee-Moon Wang, Christopher Wai-Kei Lam, Mei Wang, Iris Hiu-Shuen Chan, William B. Goggins, Cheuk-Man Yu, Siu-Fai Lui, and John E Sanderson

Prognostic Value of Cardiac Troponin T Is Independent of Inflammation, Residual Renal Function, and Cardiac Hypertrophy and Dysfunction in Peritoneal Dialysis Patients
Clin Chem 2007 53: 882-889. Published online March 29, 2007; 10.1373/clinchem.2006.078378 [Abstract] [Full Text] [PDF]  

Hematology:

Lysann Mauch, Andreas Lun, Maurice R.G. O’Gorman, John S. Harris, Ilka Schulze, Arturo Zychlinsky, Tobias Fuchs, Uta Oelschlägel, Sebastian Brenner, Dolphe Kutter, Angela Rösen-Wolff, and Joachim Roesler

Chronic Granulomatous Disease (CGD) and Complete Myeloperoxidase Deficiency Both Yield Strongly Reduced Dihydrorhodamine 123 Test Signals but Can Be Easily Discerned in Routine Testing for CGD
Clin Chem 2007 53: 890-896. Published online March 23, 2007; 10.1373/clinchem.2006.083444 [Abstract] [Full Text] [PDF]  

Endocrinology and Metabolism:

Eric S. Kilpatrick, Alan S. Rigby, and Stephen L. Atkin

Variability in the Relationship between Mean Plasma Glucose and HbA_1c: Implications for the Assessment of Glycemic Control
Clin Chem 2007 53: 897-901. Published online March 23, 2007; 10.1373/clinchem.2006.079756 [Abstract] [Full Text] [PDF]  

Manfred Rauh, Michael Gröschl, and Wolfgang Rascher

Simultaneous Quantification of Ghrelin and Desacyl-Ghrelin by Liquid Chromatography–Tandem Mass Spectrometry in Plasma, Serum, and Cell Supernatants
Clin Chem 2007 53: 902-910. Published online March 23, 2007; 10.1373/clinchem.2006.078956 [Abstract] [Full Text] [PDF]  

Kristofer S. Fritz, R. Bruce Wilcox, and Jerald C. Nelson

A Direct Free Thyroxine (T₄) Immunoassay with the Characteristics of a Total T₄ Immunoassay
Clin Chem 2007 53: 911-915. Published online March 15, 2007; 10.1373/clinchem.2006.083915 [Abstract] [Full Text] [PDF]  

François-Guillaume Debray, Grant A. Mitchell, Pierre Allard, Brian H. Robinson, James A. Hanley, and Marie Lambert

Diagnostic Accuracy of Blood Lactate-to-Pyruvate Molar Ratio in the Differential Diagnosis of Congenital Lactic Acidosis
Clin Chem 2007 53: 916-921. Published online March 23, 2007; 10.1373/clinchem.2006.081166 [Abstract] [Full Text] [PDF] 081166.Supplemental Data  

Automation and Analytical Techniques:

Susan E. Manley, Irene M. Stratton, Penelope M. Clark, and Stephen D. Luzio

Comparison of 11 Human Insulin Assays: Implications for Clinical Investigation and Research
Clin Chem 2007 53: 922-932. Published online March 15, 2007; 10.1373/clinchem.2006.077784 [Abstract] [Full Text] [PDF] Supplemental Data  

Ashish Misra, Jun-Yan Hong, and Sobin Kim

Multiplex Genotyping of Cytochrome P450 Single-Nucleotide Polymorphisms by Use of MALDI-TOF Mass Spectrometry
Clin Chem 2007 53: 933-939. Published online March 23, 2007; 10.1373/clinchem.2006.080739 [Abstract] [Full Text] [PDF] 080739.Supplemental Data  

General Clinical Chemistry:

Lili Kazemi-Shirazi, Georg Endler, Stefan Winkler, Thomas Schickbauer, Oswald Wagner, and Claudia Marsik

Gamma Glutamyltransferase and Long-Term Survival: Is It Just the Liver?
Clin Chem 2007 53: 940-946. Published online March 23, 2007; 10.1373/clinchem.2006.081620 [Abstract] [Full Text] [PDF] 081620.Kazemi Supplemental Data  

Claus Gyrup, Michael Christiansen, and Claus Oxvig

Quantification of Proteolytically Active Pregnancy-Associated Plasma Protein-A with an Assay Based on Quenched Fluorescence
Clin Chem 2007 53: 947-954. Published online March 15, 2007; 10.1373/clinchem.2006.080614 [Abstract] [Full Text] [PDF]  

Clinical Immunology:

Miloslav Kverka, Jaroslava Burianova, Raja Lodinova-Zadnikova, Ingrid Kocourkova, Jana Cinova, Ludmila Tuckova, and Helena Tlaskalova-Hogenova

Cytokine Profiling in Human Colostrum and Milk by Protein Array
Clin Chem 2007 53: 955-962. Published online March 15, 2007; 10.1373/clinchem.2006.077107 [Abstract] [Full Text] [PDF]  

Nutrition:

Robert Clarke, Paul Sherliker, Harold Hin, Ebba Nexo, Anne Mette Hvas, Joern Schneede, Jacqueline Birks, Per M. Ueland, Kathleen Emmens, John M. Scott, Anne M. Molloy, and John Grimley Evans

Detection of Vitamin B₁₂ Deficiency in Older People by Measuring Vitamin B₁₂ or the Active Fraction of Vitamin B₁₂, Holotranscobalamin
Clin Chem 2007 53: 963-970. Published online March 15, 2007; 10.1373/clinchem.2006.080382 [Abstract] [Full Text] [PDF]  

Other Areas of Clinical Chemistry:

Lise Bathum, Inge Petersen, Lene Christiansen, Agnieszka Konieczna, Thorkild I.A. Sørensen, and Kirsten O. Kyvik

Genetic and Environmental Influences on Plasma Homocysteine: Results from a Danish Twin Study
Clin Chem 2007 53: 971-979. Published online April 5, 2007; 10.1373/clinchem.2006.082149 [Abstract] [Full Text] [PDF]  

Technical Briefs:

Heidi Rossmann, Elena Büchler, Jürgen J. Wenzel, Carolin Neukirch, Jean-Baptist du Prel, and Karl J. Lackner

Evaluation of a New Pooling Strategy Based on Leukocyte Count for Rapid Quantification of Allele Frequencies
Clin Chem 2007 53: 980-982. Published online April 5, 2007; 10.1373/clinchem.2006.083691 [Abstract] [Full Text] [PDF] 083691.Supplemental Data  

Pasquale Florio, Raul Felipe Abella, Teresa de la Torre, Alessandro Giamberti, Stefano Luisi, Gianfranco Butera, Alessandro Cazzaniga, Alessandro Frigiola, Felice Petraglia, and Diego Gazzolo

Perioperative Activin A Concentrations as a Predictive Marker of Neurologic Abnormalities in Children after Open Heart Surgery
Clin Chem 2007 53: 982-985. Published online March 15, 2007; 10.1373/clinchem.2006.077149 [Abstract] [Full Text] [PDF]  

Kristofer S. Fritz, R. Bruce Wilcox, and Jerald C. Nelson

Quantifying Spurious Free T₄ Results Attributable to Thyroxine-Binding Proteins in Serum Dialysates and Ultrafiltrates
Clin Chem 2007 53: 985-988. Published online March 29, 2007; 10.1373/clinchem.2007.085316 [Abstract] [Full Text] [PDF] 085316.Supplemental Data  

Letters to the Editor:

Carlie S. Sigel and David G. Grenache

Detection of Unexpected Isoforms of Human Chorionic Gonadotropin by Qualitative Tests
Clin Chem 2007 53: 989-990. [Extract] [Full Text] [PDF]  

Stephen O. Brennan, Tim Chan, and Campbell Sheen

Novel Hemoglobin (Hb Grey Lynn) Substitution (91LeuPhe) Affects Heme Interactions and ₁ß₂ Contacts
Clin Chem 2007 53: 990-991. [Extract] [Full Text] [PDF]  

Dongzhi Li

A Multiplex Quantitative Fluorescent PCR Test for Prenatal Diagnosis of Hb Barts Hydrops Fetalis
Clin Chem 2007 53: 991-992. [Extract] [Full Text] [PDF]  

Mahesh Choolani, Sherry Ho Sze Yee, and Samuel Chong

The authors of the article cited above respond:
Clin Chem 2007 53: 992. [Extract] [Full Text] [PDF]  

Ma Lirios Juliá-Sanchis, Pedro Luis Estela-Burriel, Francisco Javier Lirón-Hernández, and Antonio Guerrero-Espejo

Rapid Differential Diagnosis between Subarachnoid Hemorrhage and Traumatic Lumbar Puncture by D-Dimer Assay
Clin Chem 2007 53: 993. [Extract] [Full Text] [PDF]  

Robert M. Bossarte, Mary Jean Brown, and Robert L. Jones

Blood Lead Misclassification Due to Defective LeadCare® Blood Lead Testing Equipment
Clin Chem 2007 53: 994-995. [Extract] [Full Text] [PDF]  

Matthew W. Martinez, Luciano Babuin, Imran S. Syed, Da-Li Feng, Wayne L. Miller, Verghese Mathew, Jerome F. Breen, and Allan S. Jaffe

Myocardial Infarction with Normal Coronary Arteries: A Role for MRI?
Clin Chem 2007 53: 995-996. [Extract] [Full Text] [PDF]  

Corrections:

Correction
Clin Chem 2007 53: 997. [Extract] [Full Text] [PDF]  

Book, Software, and Web Site Reviews:

Anders Kallner

Understanding Clinical Papers, 2nd Edition. David Bowers, Allan House, and David Owens. Chichester, West Sussex, England: John Wiley & Sons Ltd., 2006, 232 pages, $40.00, paperback. ISBN: 0-470-09130-4.
Clin Chem 2007 53: 998. [Extract] [Full Text] [PDF]  

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