Editorials:

Andrew McCaddon and Peter R. Hudson

Methylation and Phosphorylation: A Tangled Relationship?
Clin Chem 2007 53: 999-1000. [Extract] [Full Text] [PDF]  

Bob Palais

Quantitative Heteroduplex Analysis
Clin Chem 2007 53: 1001-1003. [Extract] [Full Text] [PDF]  

Eleftherios P. Diamandis

Oncopeptidomics: A Useful Approach for Cancer Diagnosis?
Clin Chem 2007 53: 1004-1006. [Extract] [Full Text] [PDF]  

Roger D. Klein

The Pain Protective Haplotype: Introducing the Modern Genetic Test
Clin Chem 2007 53: 1007-1009. [Extract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Jörn Lötsch, Inna Belfer, Anja Kirchhof, Bikash K. Mishra, Mitchell B. Max, Alexandra Doehring, Michael Costigan, Clifford J. Woolf, Gerd Geisslinger, and Irmgard Tegeder

Reliable Screening for a Pain-Protective Haplotype in the GTP Cyclohydrolase 1 Gene (GCH1) Through the Use of 3 or Fewer Single Nucleotide Polymorphisms
Clin Chem 2007 53: 1010-1015. Published online March 15, 2007; 10.1373/clinchem.2006.082883 [Abstract] [Full Text] [PDF] 082883.Supplemental Data  

Kerstin L. Edlefsen, Jonathan F. Tait, Mark H. Wener, and Michael Astion

Utilization and Diagnostic Yield of Neurogenetic Testing at a Tertiary Care Facility
Clin Chem 2007 53: 1016-1022. Published online April 19, 2007; 10.1373/clinchem.2006.083360 [Abstract] [Full Text] [PDF]  

Sara Bremer, Helge Rootwelt, and Stein Bergan

Real-Time PCR Determination of IMPDH1 and IMPDH2 Expression in Blood Cells
Clin Chem 2007 53: 1023-1029. Published online April 26, 2007; 10.1373/clinchem.2006.081968 [Abstract] [Full Text] [PDF] 081968.Supplemental Data  

Elizabeth Herness Peters, Sandra Rojas-Caro, Mitchell G. Brigell, Robert J. Zahorchak, Shelley Ann des Etages, Patricia L. Ruppel, Charles R. Knight, Bradley Austermiller, Myrna C. Graham, Steve Wowk, Sean Banks, Lakshmi V. Madabusi, Patrick Turk, Donna Wilder, Carole Kempfer, Terry W. Osborn, and James C. Willey

Quality-Controlled Measurement Methods for Quantification of Variations in Transcript Abundance in Whole Blood Samples from Healthy Volunteers
Clin Chem 2007 53: 1030-1037. Published online April 13, 2007; 10.1373/clinchem.2006.078154 [Abstract] [Full Text] [PDF] 078154.Supplemental Data  

Sung Jae Kim, David J. Dix, Kary E. Thompson, Rachel N. Murrell, Judith E. Schmid, Jane E. Gallagher, and John C. Rockett

Effects of Storage, RNA Extraction, Genechip Type, and Donor Sex on Gene Expression Profiling of Human Whole Blood
Clin Chem 2007 53: 1038-1045. Published online April 13, 2007; 10.1373/clinchem.2006.078436 [Abstract] [Full Text] [PDF] 078436.Supplemental Data  

Kok Seong Lim, Robert K. Naviaux, and Richard H. Haas

Quantitative Mitochondrial DNA Mutation Analysis by Denaturing HPLC
Clin Chem 2007 53: 1046-1052. Published online April 19, 2007; 10.1373/clinchem.2006.083303 [Abstract] [Full Text] [PDF] 083303.Supplemental Data  

Hemostasis and Thrombosis:

Isabella Russo, Paola Del Mese, Gabriella Doronzo, Alessandro De Salve, Mariantonietta Secchi, Mariella Trovati, and Giovanni Anfossi

Platelet Resistance to the Antiaggregatory Cyclic Nucleotides in Central Obesity Involves Reduced Phosphorylation of Vasodilator-Stimulated Phosphoprotein
Clin Chem 2007 53: 1053-1060. Published online April 26, 2007; 10.1373/clinchem.2006.076208 [Abstract] [Full Text] [PDF]  

Proteomics and Protein Markers:

Yuan-Yuan Li, Chi Zhang, Bo-Sheng Li, Li-Fan Zhao, Xiao-bo Li, Wen-Jie Yang, and Shun-Qing Xu

Ultrasensitive Densitometry Detection of Cytokines with Nanoparticle-Modified Aptamers
Clin Chem 2007 53: 1061-1066. Published online April 19, 2007; 10.1373/clinchem.2006.082271 [Abstract] [Full Text] [PDF] 082271.Supplemental Data  

Mary F. Lopez, Alvydas Mikulskis, Scott Kuzdzal, Eva Golenko, Emanuel F. Petricoin, III, Lance A. Liotta, Wayne F. Patton, Gordon R. Whiteley, Kevin Rosenblatt, Prem Gurnani, Animesh Nandi, Samuel Neill, Stuart Cullen, Martin O’Gorman, David Sarracino, Christopher Lynch, Andrew Johnson, William Mckenzie, and David Fishman

A Novel, High-Throughput Workflow for Discovery and Identification of Serum Carrier Protein-Bound Peptide Biomarker Candidates in Ovarian Cancer Samples
Clin Chem 2007 53: 1067-1074. Published online April 26, 2007; 10.1373/clinchem.2006.080721 [Abstract] [Full Text] [PDF] 080721.Supplemental data  

Winfried März, Beate Tiran, Ursula Seelhorst, Britta Wellnitz, Johann Bauersachs, Bernhard R. Winkelmann, and Bernhard O. Boehm

N-Terminal Pro-B-Type Natriuretic Peptide Predicts Total and Cardiovascular Mortality in Individuals with or without Stable Coronary Artery Disease: The Ludwigshafen Risk and Cardiovascular Health Study
Clin Chem 2007 53: 1075-1083. Published online April 19, 2007; 10.1373/clinchem.2006.075929 [Abstract] [Full Text] [PDF]  

Cancer Diagnostics:

Maureen Cronin, Chithra Sangli, Mei-Lan Liu, Mylan Pho, Debjani Dutta, Anhthu Nguyen, Jennie Jeong, Jenny Wu, Kim Clark Langone, and Drew Watson

Analytical Validation of the Oncotype DX Genomic Diagnostic Test for Recurrence Prognosis and Therapeutic Response Prediction in Node-Negative, Estrogen Receptor–Positive Breast Cancer
Clin Chem 2007 53: 1084-1091. Published online April 26, 2007; 10.1373/clinchem.2006.076497 [Abstract] [Full Text] [PDF] Supplemental Data  

Lipids, Lipoproteins, and Cardiovascular Risk Factors:

Ji-Sun Lim, Duk-Hee Lee, Joo-Yun Park, Soo-Hee Jin, and David R. Jacobs, Jr

A Strong Interaction between Serum -Glutamyltransferase and Obesity on the Risk of Prevalent Type 2 Diabetes: Results from the Third National Health and Nutrition Examination Survey
Clin Chem 2007 53: 1092-1098. Published online May 3, 2007; 10.1373/clinchem.2006.079814 [Abstract] [Full Text] [PDF]  

Hematology:

Christine L.H. Snozek, Amy K. Saenger, Philip R. Greipp, Sandra C. Bryant, Robert A. Kyle, S. Vincent Rajkumar, and Jerry A. Katzmann

Comparison of Bromcresol Green and Agarose Protein Electrophoresis for Quantitation of Serum Albumin in Multiple Myeloma
Clin Chem 2007 53: 1099-1103. Published online April 26, 2007; 10.1373/clinchem.2007.088252 [Abstract] [Full Text] [PDF]  

Endocrinology and Metabolism:

Isolde Seiden-Long and Reinhold Vieth

Evaluation of a 1,25-Dihydroxyvitamin D Enzyme Immunoassay
Clin Chem 2007 53: 1104-1108. Published online April 13, 2007; 10.1373/clinchem.2006.077560 [Abstract] [Full Text] [PDF]  

Tim Cundy, Anne Horne, Mark Bolland, Greg Gamble, and James Davidson

Bone Formation Markers in Adults with Mild Osteogenesis Imperfecta
Clin Chem 2007 53: 1109-1114. Published online April 13, 2007; 10.1373/clinchem.2006.083055 [Abstract] [Full Text] [PDF] 083055.Supplemental Data  

Automation and Analytical Techniques:

Joris R. Delanghe, Anders Helander, Jos P.M. Wielders, J. Maurits Pekelharing, Heinz J. Roth, François Schellenberg, Catherine Born, Eray Yagmur, Wolfgang Gentzer, and Harald Althaus

Development and Multicenter Evaluation of the N Latex CDT Direct Immunonephelometric Assay for Serum Carbohydrate-Deficient Transferrin
Clin Chem 2007 53: 1115-1121. Published online April 5, 2007; 10.1373/clinchem.2006.084459 [Abstract] [Full Text] [PDF] 084459.Supplemental Data  

General Clinical Chemistry:

John Mahoney and John Ellison

Assessing the Quality of Glucose Monitor Studies: A Critical Evaluation of Published Reports
Clin Chem 2007 53: 1122-1128. Published online May 3, 2007; 10.1373/clinchem.2006.083493 [Abstract] [Full Text] [PDF]  

Rima Obeid, Mariz Kasoha, Jean-Pierre Knapp, Panagiotis Kostopoulos, George Becker, Klaus Fassbender, and Wolfgang Herrmann

Folate and Methylation Status in Relation to Phosphorylated Tau Protein_(181P) and ß-Amyloid(1–42) in Cerebrospinal Fluid
Clin Chem 2007 53: 1129-1136. Published online March 23, 2007; 10.1373/clinchem.2006.085241 [Abstract] [Full Text] [PDF] 085241.Supplemental Data  

Clinical Immunology:

Jochen Metzger, Philipp von Landenberg, Marcus Kehrel, Alexander Buhl, Karl J. Lackner, and Peter B. Luppa

Biosensor Analysis of ß2-Glycoprotein I–Reactive Autoantibodies: Evidence for Isotype-Specific Binding and Differentiation of Pathogenic from Infection-Induced Antibodies
Clin Chem 2007 53: 1137-1143. Published online April 13, 2007; 10.1373/clinchem.2006.079632 [Abstract] [Full Text] [PDF] 079632.Supplemental data  

Nutrition:

Dolores Corella, Donna K. Arnett, Michael Y. Tsai, Edmond K. Kabagambe, James M. Peacock, James E. Hixson, Robert J. Straka, Michael Province, Chao-Qiang Lai, Laurence D. Parnell, Ingrid Borecki, and Jose M. Ordovas

The –256T>C Polymorphism in the Apolipoprotein A-II Gene Promoter Is Associated with Body Mass Index and Food Intake in the Genetics of Lipid Lowering Drugs and Diet Network Study
Clin Chem 2007 53: 1144-1152. Published online April 19, 2007; 10.1373/clinchem.2006.084863 [Abstract] [Full Text] [PDF]  

Technical Briefs:

Dihua Shangguan, Zehui Charles Cao, Ying Li, and Weihong Tan

Aptamers Evolved from Cultured Cancer Cells Reveal Molecular Differences of Cancer Cells in Patient Samples
Clin Chem 2007 53: 1153-1155. Published online April 26, 2007; 10.1373/clinchem.2006.083246 [Abstract] [Full Text] [PDF] 083246.Supplemental Data  

Joseph Skulan, Thomas Bullen, Ariel D. Anbar, J. Edward Puzas, Linda Shackelford, Adrian LeBlanc, and Scott M. Smith

Natural Calcium Isotopic Composition of Urine as a Marker of Bone Mineral Balance
Clin Chem 2007 53: 1155-1158. Published online April 26, 2007; 10.1373/clinchem.2006.080143 [Abstract] [Full Text] [PDF] 080143.Supplemental Data  

Letters to the Editor:

Giovanni Targher, Massimo Franchini, Gian Cesare Guidi, Michele Muggeo, and Giuseppe Lippi

Alanine Aminotransferase as an Independent Predictor of Incident Nonalcoholic Fatty Liver Disease
Clin Chem 2007 53: 1159. [Extract] [Full Text] [PDF]  

Yoosoo Chang, Seungho Ryu, Eunju Sung, and Yumi Jang

Reply to Alanine Aminotransferase as an Independent Predictor of Incident Nonalcoholic Fatty Liver Disease
Clin Chem 2007 53: 1159-1161. [Extract] [Full Text] [PDF]  

Mads V. Hollegaard, Karina M. Sørensen, Høgni K. Petersen, Maria B. Arnardottir, Bent Nørgaard-Pedersen, Poul Thorsen, and David M. Hougaard

Whole Genome Amplification and Genetic Analysis after Extraction of Proteins from Dried Blood Spots
Clin Chem 2007 53: 1161-1162. [Extract] [Full Text] [PDF] 082313.Supplemental data  

Francisco J. Morón, Nicolás Mendoza, Francisco Quereda, Francisco Vázquez, Reposo Ramírez-Lorca, Juan Velasco, Jose L. Gallo, Ana Salinas, Txantón Martínez-Astorquiza, Rafael Sánchez-Borrego, Maria E. Sáez, and Agustín Ruiz

Pyrosequencing Technology for Automated Detection of the BMP15 A180T Variant in Spanish Postmenopausal Women
Clin Chem 2007 53: 1162-1164. [Extract] [Full Text] [PDF] 081307.Supplemental Data  

David Friedecky, Jana Tomkova, and Tomas Adam

Determination of ITPase Activity by Capillary Electrophoresis
Clin Chem 2007 53: 1164-1165. [Extract] [Full Text] [PDF]  

Vivienne M. Homer and Peter M. George

Novel Mutation (c.G1124A) in Exon 9 of the APOB Gene Causes Aberrant Splicing and Familial Hypobetalipoproteinemia
Clin Chem 2007 53: 1165-1167. [Extract] [Full Text] [PDF]  

Kiyonori Miura, Kentaro Yamasaki, Shoko Miura, Koh-ichiro Yoshiura, Takako Shimada, Daisuke Nakayama, Norio Niikawa, and Hideaki Masuzaki

Circulating Cell-Free Placental mRNA in the Maternal Plasma as a Predictive Marker for Twin-Twin Transfusion Syndrome
Clin Chem 2007 53: 1167-1168. [Extract] [Full Text] [PDF]  

Simone G. van Breda, Janneke G. Hogervorst, Leo J. Schouten, Ad M. Knaapen, Joost H. van Delft, R. Alexandra Goldbohm, Frederik J. van Schooten, and Piet A. van den Brandt

Toenails: An Easily Accessible and Long-Term Stable Source of DNA for Genetic Analyses in Large-Scale Epidemiological Studies
Clin Chem 2007 53: 1168-1170. [Extract] [Full Text] [PDF] Data Supplement 085043.Supplemental Data  

Book, Software, and Web Site Reviews:

Sarah D. de Ferranti

Review of The Metabolic Syndrome. Christopher D. Byrne and Sarah H. Wild, eds. Chichester, West Sussex, England: John Wiley & Sons Ltd., 2005, 432 pp., $110.00, hardcover. ISBN 0-470-02511-5.
Clin Chem 2007 53: 1171. [Extract] [Full Text] [PDF]  

Sverre Sandberg

Clinical Diagnostic Technology-The Total Testing Process, Volume 3: The Postanalytical Phase. Kory M. Ward-Cook, Craig A. Lehmann, Larry E. Schoeff, and Robert H. Williams, eds. Washington, DC: AACC Press, 2006, 216 pp., $65 ($52.00 AACC members), softcover. ISBN 978-1-59425-055-2.
Clin Chem 2007 53: 1171-1172. [Extract] [Full Text] [PDF]  

Johannes Mair

Natriuretic Peptides: The Hormones of the Heart. Aldo Clerico and Michele Emdin, eds. Trento, Italy: Springer-Verlag Italia, 2006, 184 pp., $149.00, hardcover. ISBN 978-88-470-0497-9.
Clin Chem 2007 53: 1172-1173. [Extract] [Full Text] [PDF]  

Geza Bodor

Quick Guide to Coagulation Testing. Marisa B. Marques and George A. Fritsma, Washington, DC: AACC Press, 2006, 62 pp., $15 ($12 AACC members), softcover. ISBN 1-59425-049-9.
Clin Chem 2007 53: 1173-1174. [Extract] [Full Text] [PDF]  

Corrections:

Correction
Clin Chem 2007 53: 1170. [Extract] [Full Text] [PDF]  

The Clinical Chemist:

David E. Bruns

The Clinical Chemist
Clin Chem 2007 53: 1175-1180. [Extract] [Full Text] [PDF]  

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