Editorials:

Rebekah L. Gundry and Jennifer E. Van Eyk

Unraveling the Complexity of Circulating Forms of Brain Natriuretic Peptide
Clin Chem 2007 53: 1181-1182. [Extract] [Full Text] [PDF]  

Falgunee K. Parekh and Thomas L. Richie

Characterization of Immune Reactivity Profiles Using Microarray Technology May Expedite Identification of Candidate Antigens for Next Generation Malaria Vaccines
Clin Chem 2007 53: 1183-1185. [Extract] [Full Text] [PDF]  

Nicolas von Ahsen and Michael Oellerich

Chip-Based Genotyping: Translation of Pharmacogenetic Research to Clinical Practice
Clin Chem 2007 53: 1186-1187. [Extract] [Full Text] [PDF]  

Opinion:

Manuel Salto-Tellez

A Case for Integrated Morphomolecular Diagnostic Pathologists
Clin Chem 2007 53: 1188-1190. [Extract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Joshua G. Vandersteen, Pinar Bayrak-Toydemir, Robert A. Palais, and Carl T. Wittwer

Identifying Common Genetic Variants by High-Resolution Melting
Clin Chem 2007 53: 1191-1198. Published online May 24, 2007; 10.1373/clinchem.2007.085407 [Abstract] [Full Text] [PDF] 085407.Supplemental Data  

Yusheng Zhu, Michael Shennan, Kristen K. Reynolds, Nancy A. Johnson, Matthew R. Herrnberger, Roland Valdes, Jr, and Mark W. Linder

Estimation of Warfarin Maintenance Dose Based on VKORC1 (–1639 G>A) and CYP2C9 Genotypes
Clin Chem 2007 53: 1199-1205. Published online May 17, 2007; 10.1373/clinchem.2006.078139 [Abstract] [Full Text] [PDF]  

Liqiang Xi, Daniel G. Nicastri, Talal El-Hefnawy, Steven J. Hughes, James D. Luketich, and Tony E. Godfrey

Optimal Markers for Real-Time Quantitative Reverse Transcription PCR Detection of Circulating Tumor Cells from Melanoma, Breast, Colon, Esophageal, Head and Neck, and Lung Cancers
Clin Chem 2007 53: 1206-1215. Published online May 24, 2007; 10.1373/clinchem.2006.081828 [Abstract] [Full Text] [PDF] 081828.Supplemental Data  

Emma Williams and Gill Rumsby

Selected Exonic Sequencing of the AGXT Gene Provides a Genetic Diagnosis in 50% of Patients with Primary Hyperoxaluria Type 1
Clin Chem 2007 53: 1216-1221. Published online May 10, 2007; 10.1373/clinchem.2006.084434 [Abstract] [Full Text] [PDF] 084434.Supplemental Data  

Thomas M. Daly, Carmen M. Dumaual, Xin Miao, Mark W. Farmen, Reuben K. Njau, Dong-Jing Fu, Nancy L. Bauer, Sandra Close, Nancy Watanabe, Carsten Bruckner, Paul Hardenbol, and Richard D. Hockett

Multiplex Assay for Comprehensive Genotyping of Genes Involved in Drug Metabolism, Excretion, and Transport
Clin Chem 2007 53: 1222-1230. Published online May 17, 2007; 10.1373/clinchem.2007.086348 [Abstract] [Full Text] [PDF] 086348.Supplemental Data  

Hemostasis and Thrombosis:

Boris T. Ivandic, Eberhard Spanuth, Detlef Haase, Heiko-Gundmar Lestin, and Hugo A. Katus

Increased Plasma Concentrations of Soluble CD40 Ligand in Acute Coronary Syndrome Depend on in Vitro Platelet Activation
Clin Chem 2007 53: 1231-1234. Published online May 10, 2007; 10.1373/clinchem.2007.085332 [Abstract] [Full Text] [PDF]  

Cihan Ay, Lea V. Jungbauer, Thomas Sailer, Theres Tengler, Silvia Koder, Alexandra Kaider, Simon Panzer, Peter Quehenberger, Ingrid Pabinger, and Christine Mannhalter

High Concentrations of Soluble P-Selectin Are Associated with Risk of Venous Thromboembolism and the P-Selectin Thr715 Variant
Clin Chem 2007 53: 1235-1243. Published online May 17, 2007; 10.1373/clinchem.2006.085068 [Abstract] [Full Text] [PDF] 085068.Supplemental Data  

Proteomics and Protein Markers:

Julian C. Gray, Patrick H. Corran, Elena Mangia, Michael W. Gaunt, Qiuxiang Li, Kevin K.A. Tetteh, Spencer D. Polley, David J. Conway, Anthony A. Holder, Tito Bacarese-Hamilton, Eleanor M. Riley, and Andrea Crisanti

Profiling the Antibody Immune Response against Blood Stage Malaria Vaccine Candidates
Clin Chem 2007 53: 1244-1253. Published online May 17, 2007; 10.1373/clinchem.2006.081695 [Abstract] [Full Text] [PDF] 081695.Supplemental Data  

Richard K.T. Kam, Terence C.W. Poon, Henry L.Y. Chan, Nathalie Wong, Alex Y. Hui, and Joseph J.Y. Sung

High-Throughput Quantitative Profiling of Serum N-Glycome by MALDI-TOF Mass Spectrometry and N-Glycomic Fingerprint of Liver Fibrosis
Clin Chem 2007 53: 1254-1263. Published online May 17, 2007; 10.1373/clinchem.2007.085563 [Abstract] [Full Text] [PDF] 085563.Supplemental Data  

Katharina-Susanne Spanaus, Florian Kronenberg, Eberhard Ritz, Ralph Schlapbach, Danilo Fliser, Martin Hersberger, Barbara Kollerits, Paul König, Arnold von Eckardstein for the Mild-to-Moderate Kidney Disease Study Group

B-Type Natriuretic Peptide Concentrations Predict the Progression of Nondiabetic Chronic Kidney Disease: The Mild-to-Moderate Kidney Disease Study
Clin Chem 2007 53: 1264-1272. Published online May 3, 2007; 10.1373/clinchem.2006.083170 [Abstract] [Full Text] [PDF]  

Cancer Diagnostics:

Michael Mullins, Laurent Perreard, John F. Quackenbush, Nicholas Gauthier, Steven Bayer, Matthew Ellis, Joel Parker, Charles M. Perou, Aniko Szabo, and Philip S. Bernard

Agreement in Breast Cancer Classification between Microarray and Quantitative Reverse Transcription PCR from Fresh-Frozen and Formalin-Fixed, Paraffin-Embedded Tissues
Clin Chem 2007 53: 1273-1279. Published online May 24, 2007; 10.1373/clinchem.2006.083725 [Abstract] [Full Text] [PDF] 083725.Supplemental Data  

Anieta M. Sieuwerts, Pernille A. Usher, Marion E. Meijer-van Gelder, Mieke Timmermans, John W.M. Martens, Nils Brünner, Jan G.M. Klijn, Hanne Offenberg, and John A. Foekens

Concentrations of TIMP1 mRNA Splice Variants and TIMP-1 Protein Are Differentially Associated with Prognosis in Primary Breast Cancer
Clin Chem 2007 53: 1280-1288. Published online May 3, 2007; 10.1373/clinchem.2006.082800 [Abstract] [Full Text] [PDF] 082800.Supplemental Data  

Lipids, Lipoproteins, and Cardiovascular Risk Factors:

Michele Emdin, Claudio Passino, Concetta Prontera, Marianna Fontana, Roberta Poletti, Alessandra Gabutti, Chiara Mammini, Alberto Giannoni, Luc Zyw, Giancarlo Zucchelli, and Aldo Clerico

Comparison of Brain Natriuretic Peptide (BNP) and Amino-Terminal ProBNP for Early Diagnosis of Heart Failure
Clin Chem 2007 53: 1289-1297. Published online May 10, 2007; 10.1373/clinchem.2006.080234 [Abstract] [Full Text] [PDF]  

Benjamin Dieplinger, Arno Lingenhel, Nadja Baumgartner, Werner Poelz, Hans Dieplinger, Meinhard Haltmayer, Florian Kronenberg, and Thomas Mueller

Increased Serum Lipoprotein(a) Concentrations and Low Molecular Weight Phenotypes of Apolipoprotein(a) Are Associated with Symptomatic Peripheral Arterial Disease
Clin Chem 2007 53: 1298-1305. Published online May 24, 2007; 10.1373/clinchem.2007.088013 [Abstract] [Full Text] [PDF]  

Drug Monitoring and Toxicology:

Max Reinshagen, Ekkehard Schütz, Victor W. Armstrong, Christoph Behrens, Christian von Tirpitz, Andreas Stallmach, Hans Herfarth, Jürgen Stein, Peter Bias, Guido Adler, Maria Shipkova, Wolfgang Kruis, Michael Oellerich, and Nicolas von Ahsen

6-Thioguanine Nucleotide–Adapted Azathioprine Therapy Does Not Lead to Higher Remission Rates Than Standard Therapy in Chronic Active Crohn Disease: Results from a Randomized, Controlled, Open Trial
Clin Chem 2007 53: 1306-1314. Published online May 10, 2007; 10.1373/clinchem.2007.086215 [Abstract] [Full Text] [PDF]  

Kenneth Ihenetu, Hassan M. Qazzaz, Fabian Crespo, Rafael Fernandez-Botran, and Roland Valdes, Jr

Digoxin-Like Immunoreactive Factors Induce Apoptosis in Human Acute T-Cell Lymphoblastic Leukemia
Clin Chem 2007 53: 1315-1322. Published online May 10, 2007; 10.1373/clinchem.2006.082081 [Abstract] [Full Text] [PDF] 082081.Supplemental Data  

Automation and Analytical Techniques:

Dianping Tang, Ruo Yuan, and Yaqin Chai

Magnetic Control of an Electrochemical Microfluidic Device with an Arrayed Immunosensor for Simultaneous Multiple Immunoassays
Clin Chem 2007 53: 1323-1329. Published online May 17, 2007; 10.1373/clinchem.2006.085126 [Abstract] [Full Text] [PDF]  

Informatics and Statistics:

Sirikit Ho, Zoltan Lukacs, Georg F. Hoffmann, Martin Lindner, and Thomas Wetter

Feature Construction Can Improve Diagnostic Criteria for High-Dimensional Metabolic Data in Newborn Screening for Medium-Chain Acyl-CoA Dehydrogenase Deficiency
Clin Chem 2007 53: 1330-1337. Published online May 18, 2007; 10.1373/clinchem.2006.081802 [Abstract] [Full Text] [PDF] 081802.Supplemental Data  

Laboratory Management:

Paolo Carraro and Mario Plebani

Errors in a Stat Laboratory: Types and Frequencies 10 Years Later
Clin Chem 2007 53: 1338-1342. Published online May 24, 2007; 10.1373/clinchem.2007.088344 [Abstract] [Full Text] [PDF]  

Marit Rynning, Tore Wentzel-Larsen, and Bjørn J. Bolann

A Model for an Uncertainty Budget for Preanalytical Variables in Clinical Chemistry Analyses
Clin Chem 2007 53: 1343-1348. Published online May 10, 2007; 10.1373/clinchem.2007.086371 [Abstract] [Full Text] [PDF] 086371.Supplemental Data  

Claudio Orlando, Paolo Verderio, Ronald Maatman, Jan Danneberg, Simon Ramsden, Michael Neumaier, Domenica Taruscio, Vincenzo Falbo, Robert Jansen, Claudia Casini-Raggi, Francesca Malentacchi, Ettore Marubini, Sara Pizzamiglio, Kris Vernelen, Jean-Claude Libeer, Vladimir Palicka, and Mario Pazzagli

EQUAL-qual: A European Program for External Quality Assessment of Genomic DNA Extraction and PCR Amplification
Clin Chem 2007 53: 1349-1357. [Abstract] [Full Text] [PDF] 084004.Supplemental Data  

General Clinical Chemistry:

Lee J. Lefkowitz, Joseph M. Kupina, Nigel L. Hirth, Rachel M. Henry, Georgia Y. Noland, John Y. Barbee, Jr, Joey Y. Zhou, and Coleen B. Weese

Intraindividual Stability of Human Erythrocyte Cholinesterase Activity
Clin Chem 2007 53: 1358-1363. Published online May 10, 2007; 10.1373/clinchem.2006.085258 [Abstract] [Full Text] [PDF] 085258.Supplemental Data  

Pediatric Clinical Chemistry:

Giancarlo la Marca, Sabrina Malvagia, Elisabetta Pasquini, Marzia Innocenti, Maria Alice Donati, and Enrico Zammarchi

Rapid 2nd-Tier Test for Measurement of 3-OH-Propionic and Methylmalonic Acids on Dried Blood Spots: Reducing the False-Positive Rate for Propionylcarnitine during Expanded Newborn Screening by Liquid Chromatography–Tandem Mass Spectrometry
Clin Chem 2007 53: 1364-1369. Published online May 17, 2007; 10.1373/clinchem.2007.087775 [Abstract] [Full Text] [PDF]  

Technical Briefs:

Justin T. Baca, Christopher R. Taormina, Eleanor Feingold, David N. Finegold, Joseph J. Grabowski, and Sanford A. Asher

Mass Spectral Determination of Fasting Tear Glucose Concentrations in Nondiabetic Volunteers
Clin Chem 2007 53: 1370-1372. Published online May 10, 2007; 10.1373/clinchem.2006.078543 [Abstract] [Full Text] [PDF] 078543.Supplemental Data  

Xin Lin, James A. Flint, Marco Azaro, Thomas Coradetti, Wesley M. Kopacka, Deanna L. Streck, Zhuying Wang, James Dermody, and Wlodek Mandecki

Microtransponder-Based Multiplex Assay for Genotyping Cystic Fibrosis
Clin Chem 2007 53: 1372-1376. Published online May 17, 2007; 10.1373/clinchem.2006.081810 [Abstract] [Full Text] [PDF] 081810.Supplemental Data  

Daniela Fortini, Andrea Ciammaruconi, Riccardo De Santis, Antonio Fasanella, Antonio Battisti, Raffaele D’Amelio, Florigio Lista, Antonio Cassone, and Alessandra Carattoli

Optimization of High-Resolution Melting Analysis for Low-Cost and Rapid Screening of Allelic Variants of Bacillus anthracis by Multiple-Locus Variable-Number Tandem Repeat Analysis
Clin Chem 2007 53: 1377-1380. Published online May 24, 2007; 10.1373/clinchem.2007.085993 [Abstract] [Full Text] [PDF] 085993.Supplemental Data  

Anja Koskela, Anna-Maria Linko-Parvinen, Perttu Hiisivuori, Adile Samaletdin, Afaf Kamal-Eldin, Matti J. Tikkanen, and Herman Adlercreutz

Quantification of Alkylresorcinol Metabolites in Urine by HPLC with Coulometric Electrode Array Detection
Clin Chem 2007 53: 1380-1383. Published online May 10, 2007; 10.1373/clinchem.2006.084764 [Abstract] [Full Text] [PDF] 084764.Supplemental Data  

Letters to the Editor:

Kristofer S. Fritz, Rene M. Weiss, Jerald C. Nelson, and R. Bruce Wilcox

Unequal Concentrations of Free T₃ and Free T₄ after Ultrafiltration
Clin Chem 2007 53: 1384-1385. [Extract] [Full Text] [PDF]  

Siegfried Burggraf, Barbara Dörhöfer, and Bernhard Olgemöller

Hybridization Probe Genotyping of the R67X Nonsense Polymorphism in the Protein Z-Dependent Protease Inhibitor Reveals a New R67Q Mutation
Clin Chem 2007 53: 1385-1387. [Extract] [Full Text] [PDF]  

Rita Machaalani, Marie Arlotto, Karen A. Waters, Evelyne Gozal, François Berger, and Maurice Dematteis

A Novel Method of Tissue Collection and Storage: Validation Using SELDI-TOF MS Analysis
Clin Chem 2007 53: 1387-1389. [Extract] [Full Text] [PDF]  

Andreas Kurth

Possible Biohazard Risk from Infectious Tissue and Culture Cells Preserved with RNAlater^TM
Clin Chem 2007 53: 1389-1390. [Extract] [Full Text] [PDF]  

Soong Lee, Myung-Geun Shin, Won-Hyeong Jo, Mi-Ji Kim, Hye-Ran Kim, Wan-Sik Lee, Dong-Ho Park, Jong-Hoon Won, Jong-Hee Shin, Soon-Pal Suh, and Dong-Wook Ryang

Association between Helicobacter pylori–Related Peptic Ulcer Tissue and Somatic Mitochondrial DNA Mutations
Clin Chem 2007 53: 1390-1392. [Extract] [Full Text] [PDF]  

Thomas von Kanel, Florentin Adolf, Mircea Schneider, Javier Sanz, and Sabina Gallati

Sample Number and Denaturation Time Are Crucial for the Accuracy of Capillary-Based LightCyclers
Clin Chem 2007 53: 1392-1394. [Extract] [Full Text] [PDF] 086249.Supplemental Data  

Yihong Wang, Bruce Beckwith, Christopher Smith, and Gary Horowitz

Misleading Glycated Hemoglobin Results in a Patient with Hemoglobin SC Disease
Clin Chem 2007 53: 1394-1395. [Extract] [Full Text] [PDF]  

The Clinical Chemist:

David E. Bruns

The Clinical Chemist
Clin Chem 2007 53: 1396. [Extract] [Full Text] [PDF]  

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