Editorials:

Marcel M. Verbeek and Marcel G.M. Olde Rikkert

Cerebrospinal Fluid Biomarkers in the Evaluation of Alzheimer Disease
Clin Chem 2008 54: 1589-1591. [Extract] [Full Text] [PDF]  

David S. Millington

Rapid and Effective Screening for Lysosomal Storage Disease: How Close Are We?
Clin Chem 2008 54: 1592-1594. [Extract] [Full Text] [PDF]  

Matthew J. McQueen and Andrew C. Don-Wauchope

Requesting and Interpreting Urine Albumin Measurements in the Primary Health Care Setting
Clin Chem 2008 54: 1595-1597. [Extract] [Full Text] [PDF]  

Nancy B. Y. Tsui

Multiple Thiopurine S-Methyltransferase Variation Detection: A Step toward Personalized Medicine
Clin Chem 2008 54: 1598-1599. [Extract] [Full Text] [PDF]  

Mini-Review:

Nashmil Emami and Eleftherios P. Diamandis

Utility of Kallikrein-Related Peptidases (KLKs) as Cancer Biomarkers
Clin Chem 2008 54: 1600-1607. Published online August 7, 2008; 10.1373/clinchem.2008.105189 [Abstract] [Full Text] [PDF] Supplemental Data  

Glen L. Hortin, Denis Sviridov, and N. Leigh Anderson

High-Abundance Polypeptides of the Human Plasma Proteome Comprising the Top 4 Logs of Polypeptide Abundance
Clin Chem 2008 54: 1608-1616. Published online August 7, 2008; 10.1373/clinchem.2008.108175 [Abstract] [Full Text] [PDF] Supplemental Data  

Proteomics and Protein Markers:

Jin-Moo Lee, Kaj Blennow, Niels Andreasen, Omar Laterza, Vijay Modur, Jitka Olander, Feng Gao, Matt Ohlendorf, and Jack H. Ladenson

The Brain Injury Biomarker VLP-1 Is Increased in the Cerebrospinal Fluid of Alzheimer Disease Patients
Clin Chem 2008 54: 1617-1623. Published online August 14, 2008; 10.1373/clinchem.2008.104497 [Abstract] [Full Text] [PDF]  

Pediatric Clinical Chemistry:

Angéla Dajnoki, Adolf Mühl, György Fekete, Joan Keutzer, Joe Orsini, Victor DeJesus, X. Kate Zhang, and Olaf A. Bodamer

Newborn Screening for Pompe Disease by Measuring Acid -Glucosidase Activity Using Tandem Mass Spectrometry
Clin Chem 2008 54: 1624-1629. Published online August 14, 2008; 10.1373/clinchem.2008.107722 [Abstract] [Full Text] [PDF]  

Evidence-Based Laboratory Medicine and Test Utilization:

Kristin M. Aakre, Geir Thue, Sumathi Subramaniam-Haavik, Tone Bukve, Howard Morris, Mathias Müller, Marijana V. Lovrencic, Inger Plum, Kaja Kallion, Alar Aab, Marge Kutt, Philippe Gillery, Nathalie Schneider, Andrea R. Horvath, Rita Onody, Wytze Oosterhuis, Carmen Ricos, Carmen Perich, Gunnar Nordin, and Sverre Sandberg

Postanalytical External Quality Assessment of Urine Albumin in Primary Health Care: An International Survey
Clin Chem 2008 54: 1630-1636. Published online August 14, 2008; 10.1373/clinchem.2007.100917 [Abstract] [Full Text] [PDF] Supplemental Data  

Molecular Diagnostics and Genetics:

Elke Schaeffeler, Ulrich M. Zanger, Michel Eichelbaum, Steven Asante-Poku, Jae-Gook Shin, and Matthias Schwab

Highly Multiplexed Genotyping of Thiopurine S-Methyltransferase Variants Using MALDI-TOF Mass Spectrometry: Reliable Genotyping in Different Ethnic Groups
Clin Chem 2008 54: 1637-1647. Published online August 7, 2008; 10.1373/clinchem.2008.103457 [Abstract] [Full Text] [PDF] Supplemental Data  

Luming Zhou, Roscoe J. Errigo, Hongzhe Lu, Mark A. Poritz, Michael T. Seipp, and Carl T. Wittwer

Snapback Primer Genotyping with Saturating DNA Dye and Melting Analysis
Clin Chem 2008 54: 1648-1656. Published online August 1, 2008; 10.1373/clinchem.2008.107615 [Abstract] [Full Text] [PDF] Supplemental Data  

Stefania Battistella, Francesco Damin, Marcella Chiari, Kathleen Delgrosso, Saul Surrey, Paolo Fortina, Maurizio Ferrari, and Laura Cremonesi

Genotyping β-Globin Gene Mutations on Copolymer-Coated Glass Slides with the Ligation Detection Reaction
Clin Chem 2008 54: 1657-1663. Published online August 14, 2008; 10.1373/clinchem.2008.107870 [Abstract] [Full Text] [PDF] Supplemental Data  

Fiona M. F. Lun, Rossa W. K. Chiu, K. C. Allen Chan, Tak Yeung Leung, Tze Kin Lau, and Y. M. Dennis Lo

Microfluidics Digital PCR Reveals a Higher than Expected Fraction of Fetal DNA in Maternal Plasma
Clin Chem 2008 54: 1664-1672. Published online August 14, 2008; 10.1373/clinchem.2008.111385 [Abstract] [Full Text] [PDF] Supplemental Data  

Endocrinology and Metabolism:

Luisa Beltran, Michael N. Fahie-Wilson, T. Joseph McKenna, Lucille Kavanagh, and Thomas P. Smith

Serum Total Prolactin and Monomeric Prolactin Reference Intervals Determined by Precipitation with Polyethylene Glycol: Evaluation and Validation on Common ImmunoAssay Platforms
Clin Chem 2008 54: 1673-1681. Published online August 21, 2008; 10.1373/clinchem.2008.105312 [Abstract] [Full Text] [PDF]  

John H. Page, Jing Ma, Michael Pollak, JoAnn E. Manson, and Susan E. Hankinson

Plasma Insulinlike Growth Factor 1 and Binding-Protein 3 and Risk of Myocardial Infarction in Women: A Prospective Study
Clin Chem 2008 54: 1682-1688. Published online August 14, 2008; 10.1373/clinchem.2008.105825 [Abstract] [Full Text] [PDF] Supplemental Data  

Automation and Analytical Techniques:

Ming-Hsun Wu, Mei-Yen Fang, Lin-Ni Jen, Hung-Chan Hsiao, Andreas Müller, and Cheng-Teng Hsu

Clinical Evaluation of Bionime Rightest GM310 Biosensors with a Simplified Electrode Fabrication for Alternative-Site Blood Glucose Tests
Clin Chem 2008 54: 1689-1695. Published online August 1, 2008; 10.1373/clinchem.2008.106328 [Abstract] [Full Text] [PDF] Supplemental Data  

Cancer Diagnostics:

Athina Markou, Emily G. Tsaroucha, Loukas Kaklamanis, Marianthi Fotinou, Vassilis Georgoulias, and Evi S. Lianidou

Prognostic Value of Mature MicroRNA-21 and MicroRNA-205 Overexpression in Non–Small Cell Lung Cancer by Quantitative Real-Time RT-PCR
Clin Chem 2008 54: 1696-1704. Published online August 21, 2008; 10.1373/clinchem.2007.101741 [Abstract] [Full Text] [PDF] Supplemental Data  

Alexander Kohlmann, Elisabeth Haschke-Becher, Barbara Wimmer, Ariana Huber-Wechselberger, Sandrine Meyer-Monard, Heike Huxol, Uwe Siegler, Michel Rossier, Thomas Matthes, Michela Rebsamen, Alberto Chiappe, Adeline Diemand, Sonja Rauhut, Andrea Johnson, Wei-min Liu, P. Mickey Williams, Lothar Wieczorek, and Torsten Haferlach

Intraplatform Reproducibility and Technical Precision of Gene Expression Profiling in 4 Laboratories Investigating 160 Leukemia Samples: The DACH Study
Clin Chem 2008 54: 1705-1715. Published online August 21, 2008; 10.1373/clinchem.2008.108506 [Abstract] [Full Text] [PDF] Supplemental Data  

Anna E. Szafranska, Martina Doleshal, Hayward S. Edmunds, Stuart Gordon, Jutta Luttges, Johanna B. Munding, Richard J. Barth, Jr, Edward J. Gutmann, Arief A. Suriawinata, J. Marc Pipas, Andrea Tannapfel, Murray Korc, Stephan A. Hahn, Emmanuel Labourier, and Gregory J. Tsongalis

Analysis of MicroRNAs in Pancreatic Fine-Needle Aspirates Can Classify Benign and Malignant Tissues
Clin Chem 2008 54: 1716-1724. Published online August 21, 2008; 10.1373/clinchem.2008.109603 [Abstract] [Full Text] [PDF]  

Brief Communications:

X. Kate Zhang, Carole S. Elbin, Wei-Lien Chuang, Samantha K. Cooper, Carla A. Marashio, Christa Beauregard, and Joan M. Keutzer

Multiplex Enzyme Assay Screening of Dried Blood Spots for Lysosomal Storage Disorders by Using Tandem Mass Spectrometry
Clin Chem 2008 54: 1725-1728. Published online August 21, 2008; 10.1373/clinchem.2008.104711 [Abstract] [Full Text] [PDF] Supplemental Data  

Luke C. Marney, Thomas J. Laha, Geoffrey S. Baird, Petrie M. Rainey, and Andrew N. Hoofnagle

Isopropanol Protein Precipitation for the Analysis of Plasma Free Metanephrines by Liquid Chromatography–Tandem Mass Spectrometry
Clin Chem 2008 54: 1729-1732. Published online August 7, 2008; 10.1373/clinchem.2008.104083 [Abstract] [Full Text] [PDF]  

Clinical Case Study:

Arturo Borzutzky, Lynda C. Schneider, and Raif S. Geha

A Girl with Severe Hand Swelling and Abdominal Cramps
Clin Chem 2008 54: 1733-1736. [Extract] [Full Text] [PDF]  

Michael M. Frank

Commentary
Clin Chem 2008 54: 1736. [Extract] [Full Text] [PDF]  

Bruce L. Zuraw

Commentary
Clin Chem 2008 54: 1737. [Extract] [Full Text] [PDF]  

Letters to the Editor:

Eric Grouzmann, Bruno Mathian, and Thierry Buclin

Calibration of Fractionated Metanephrines in Urine: Still an Issue?
Clin Chem 2008 54: 1738-1739. [Extract] [Full Text] [PDF]  

Ralph Fingerhut, Eva Simon, Esther M. Maier, Julia B. Hennermann, and Udo Wendel

Maple Syrup Urine Disease: Newborn Screening Fails to Discriminate between Classic and Variant Forms
Clin Chem 2008 54: 1739-1741. [Extract] [Full Text] [PDF]  

Lawrence de Koning, Anwar T. Merchant, Robert A. Hegele, Changchun Xie, Vlad Vuksan, Koon Teo, Salim Yusuf, Sonia S. Anand On behalf of the Study of Health Assessment and Risk in Ethnic Groups investigators

Association of the FABP2 T54 Variant with Plasma Triglycerides and Insulin Resistance in a Multiethnic Population
Clin Chem 2008 54: 1742-1744. [Extract] [Full Text] [PDF]  

Melissa R. Snyder, Raynell Clark, Sandra C. Bryant, and Jerry A. Katzmann

Quantification of Urinary Light Chains
Clin Chem 2008 54: 1744-1746. [Extract] [Full Text] [PDF]  

Mitsuko Nakashima, Masayoshi Tsuda, Akira Kinoshita, Tatsuya Kishino, Shinji Kondo, Osamu Shimokawa, Norio Niikawa, and Koh-ichiro Yoshiura

Precision of High-Throughput Single-Nucleotide Polymorphism Genotyping with Fingernail DNA: Comparison with Blood DNA
Clin Chem 2008 54: 1746-1748. [Extract] [Full Text] [PDF]  

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