Editorials:

Steven A. Carr and Leigh Anderson

Protein Quantitation through Targeted Mass Spectrometry: The Way Out of Biomarker Purgatory?
Clin Chem 2008 54: 1749-1752. [Extract] [Full Text] [PDF]  

Jerry A. Katzmann and Angela Dispenzieri

Screening Algorithms for Monoclonal Gammopathies
Clin Chem 2008 54: 1753-1755. [Extract] [Full Text] [PDF]  

Perspective:

David B. Sacks

Translating Hemoglobin A_1c into Average Blood Glucose: Implications for Clinical Chemistry
Clin Chem 2008 54: 1756-1758. Published online October 17, 2008; 10.1373/clinchem.2008.113282 [Extract] [Full Text] [PDF]  

Reviews:

Michael Gröschl

Current Status of Salivary Hormone Analysis
Clin Chem 2008 54: 1759-1769. Published online August 29, 2008; 10.1373/clinchem.2008.108910 [Abstract] [Full Text] [PDF]  

Michael J. Duffy and John Crown

A Personalized Approach to Cancer Treatment: How Biomarkers Can Help
Clin Chem 2008 54: 1770-1779. Published online September 18, 2008; 10.1373/clinchem.2008.110056 [Abstract] [Full Text] [PDF]  

Proteomics and Protein Markers:

Jens Peter Goetze, Ulf Dahlström, Jens F. Rehfeld, and Urban Alehagen

Impact of Epitope Specificity and Precursor Maturation in Pro-B–Type Natriuretic Peptide Measurement
Clin Chem 2008 54: 1780-1787. Published online September 11, 2008; 10.1373/clinchem.2008.105635 [Abstract] [Full Text] [PDF]  

Mahyar Khaleghi, Zeenat Ali, Thomas H. Mosley, Jr., Stephen T. Turner, and Iftikhar J. Kullo

Association of Soluble Cell Adhesion Molecules with Ankle-Brachial Index in a Biethnic Cohort of Predominantly Hypertensive Individuals
Clin Chem 2008 54: 1788-1795. Published online September 11, 2008; 10.1373/clinchem.2008.107003 [Abstract] [Full Text] [PDF]  

Andrew N. Hoofnagle, Jessica O. Becker, Mark H. Wener, and Jay W. Heinecke

Quantification of Thyroglobulin, a Low-Abundance Serum Protein, by Immunoaffinity Peptide Enrichment and Tandem Mass Spectrometry
Clin Chem 2008 54: 1796-1804. Published online September 18, 2008; 10.1373/clinchem.2008.109652 [Abstract] [Full Text] [PDF] Supplemental Data  

Tatiana Plavina, Marina Hincapie, Eric Wakshull, Meena Subramanyam, and William S. Hancock

Increased Plasma Concentrations of Cytoskeletal and Ca²⁺-Binding Proteins and Their Peptides in Psoriasis Patients
Clin Chem 2008 54: 1805-1814. Published online September 18, 2008; 10.1373/clinchem.2008.103770 [Abstract] [Full Text] [PDF] Supplemental Data  

Ming-Tai Lin, Shyh-Jye Chen, Yi-Lwun Ho, Kuo-Chin Huang, Chun-An Chen, Shuenn-Nan Chiu, Li-Chuan Sun, Wen-Jeng Lee, Hui-Chi Chen, Jou-Kou Wang, and Mei-Hwan Wu

Abnormal Matrix Remodeling in Adolescents and Young Adults with Kawasaki Disease Late after Onset
Clin Chem 2008 54: 1815-1822. Published online September 18, 2008; 10.1373/clinchem.2008.105023 [Abstract] [Full Text] [PDF]  

Cancer Diagnostics:

Armin P. Piehler, Nina Gulbrandsen, Peter Kierulf, and Petter Urdal

Quantitation of Serum Free Light Chains in Combination with Protein Electrophoresis and Clinical Information for Diagnosing Multiple Myeloma in a General Hospital Population
Clin Chem 2008 54: 1823-1830. Published online September 18, 2008; 10.1373/clinchem.2008.106153 [Abstract] [Full Text] [PDF]  

Chen-Hsiung Yeh, William A. Whitmire, III, and Maher Albitar

Liquid-Based Fluorescence In Situ Hybridization Assay for Detection of ERBB2 Gene Amplification in Patients with Breast Cancer
Clin Chem 2008 54: 1831-1839. Published online September 11, 2008; 10.1373/clinchem.2008.107607 [Abstract] [Full Text] [PDF]  

Anna Lempiäinen, Ulf-Håkan Stenman, Carl Blomqvist, and Kristina Hotakainen

Free β-Subunit of Human Chorionic Gonadotropin in Serum Is a Diagnostically Sensitive Marker of Seminomatous Testicular Cancer
Clin Chem 2008 54: 1840-1843. Published online September 11, 2008; 10.1373/clinchem.2008.108548 [Abstract] [Full Text] [PDF] Supplemental Data  

Maria Bujalkova, Katarina Zavodna, Tomas Krivulcik, Denisa Ilencikova, Brigitte Wolf, Michal Kovac, Judith Karner-Hanusch, Karl Heinimann, Giancarlo Marra, Josef Jiricny, and Zdena Bartosova

Multiplex SNaPshot Genotyping for Detecting Loss of Heterozygosity in the Mismatch-Repair Genes MLH1 and MSH2 in Microsatellite-Unstable Tumors
Clin Chem 2008 54: 1844-1854. Published online September 4, 2008; 10.1373/clinchem.2008.108902 [Abstract] [Full Text] [PDF] Supplemental Data  

Endocrinology and Metabolism:

Steve Shiraishi, Paul W. N. Lee, Andrew Leung, Victor H. H. Goh, Ronald S. Swerdloff, and Christina Wang

Simultaneous Measurement of Serum Testosterone and Dihydrotestosterone by Liquid Chromatography–Tandem Mass Spectrometry
Clin Chem 2008 54: 1855-1863. Published online September 18, 2008; 10.1373/clinchem.2008.103846 [Abstract] [Full Text] [PDF] Supplemental Data  

David S. Goldstein and Courtney Holmes

Neuronal Source of Plasma Dopamine
Clin Chem 2008 54: 1864-1871. Published online September 18, 2008; 10.1373/clinchem.2008.107193 [Abstract] [Full Text] [PDF]  

Evidence-based Laboratory Medicine and Test Utilization:

Eva Nagy, Joseph Watine, Peter S. Bunting, Rita Onody, Wytze P. Oosterhuis, Dunja Rogic, Sverre Sandberg, Krisztina Boda, and Andrea R. Horvath

Do Guidelines for the Diagnosis and Monitoring of Diabetes Mellitus Fulfill the Criteria of Evidence-Based Guideline Development?
Clin Chem 2008 54: 1872-1882. Published online September 4, 2008; 10.1373/clinchem.2008.109082 [Abstract] [Full Text] [PDF] Supplemental Data  

General Clinical Chemistry:

Bakary S. Drammeh, Rosemary L. Schleicher, Christine M. Pfeiffer, Ram B. Jain, Mindy Zhang, and Phuong Hong Nguyen

Effects of Delayed Sample Processing and Freezing on Serum Concentrations of Selected Nutritional Indicators
Clin Chem 2008 54: 1883-1891. Published online August 29, 2008; 10.1373/clinchem.2008.108761 [Abstract] [Full Text] [PDF] Supplemental Data  

Josiane Arnaud, Jean-Philippe Weber, Cas W. Weykamp, Patrick J. Parsons, Jurgen Angerer, Eric Mairiaux, Olav Mazarrasa, Sinikka Valkonen, Antonio Menditto, Marina Patriarca, and Andrew Taylor

Quality Specifications for the Determination of Copper, Zinc, and Selenium in Human Serum or Plasma: Evaluation of an Approach Based on Biological and Analytical Variation
Clin Chem 2008 54: 1892-1899. Published online August 21, 2008; 10.1373/clinchem.2008.108142 [Abstract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Alessandro Di Nicola, Elisa Ghezzi, Federico Gillio, Francesco Zerilli, Erlet Shehi, Diego Maritano, Massimo Panizzo, Fabrizio Bonelli, and Daniel Adlerstein

Anchor-Based Fluorescent Amplicon Generation Assays (FLAG) for Real-Time Measurement of Human Cytomegalovirus, Epstein–Barr Virus, and Varicella-Zoster Virus Viral Loads
Clin Chem 2008 54: 1900-1907. Published online August 14, 2008; 10.1373/clinchem.2008.106542 [Abstract] [Full Text] [PDF] Supplemental Data  

Mikiko Soejima and Yoshiro Koda

TaqMan-Based Real-Time PCR for Genotyping Common Polymorphisms of Haptoglobin (HP¹ and HP²)
Clin Chem 2008 54: 1908-1913. Published online September 11, 2008; 10.1373/clinchem.2008.113126 [Abstract] [Full Text] [PDF] Supplemental Data  

Clinical Case Study:

Kimberly A Chapman, Michael J. Bennett, and Neal Sondheimer

Increased C3-Carnitine in a Healthy Premature Infant
Clin Chem 2008 54: 1914-1917. [Extract] [Full Text] [PDF]  

Charles P. Venditti

Commentary
Clin Chem 2008 54: 1917-1918. [Extract] [Full Text] [PDF]  

Dietrich Matern

Commentary
Clin Chem 2008 54: 1918. [Extract] [Full Text] [PDF]  

Citation Classic:

Kurt M. Dubowski

An o-Toluidine Method for Body-Fluid Glucose Determination
Clin Chem 2008 54: 1919-1920. [Extract] [Full Text] [PDF]  

Letters to the Editor:

L. Elly A. de Wit, Hans R. Scholte, and Wim Sluiter

Correct Assay of Complex I Activity in Human Skin Fibroblasts by Timely Addition of Rotenone
Clin Chem 2008 54: 1921-1922. [Extract] [Full Text] [PDF]  

Richard J.T. Rodenburg, Berendien J.M. Stoltenborg-Hogenkamp, Liesbeth T.M. Wintjes, Jan A. Smeitink, Lambert P. van den Heuvel, and Antoon J.M. Janssen

In Reply
Clin Chem 2008 54: 1922-1924. [Extract] [Full Text] [PDF]  

Søren Risom Kristensen, Anna Maria Salling, Susanne Tofting Kristensen, and Annebirthe Bo Hansen

Unrecognized Preanalytical Problem with the Spectrophotometric Analysis of Cerebrospinal Fluid for Xanthochromia
Clin Chem 2008 54: 1924-1925. [Extract] [Full Text] [PDF]  

Mohd. A. F. Tan, Caroline J. Dean, John J. Hopwood, and Peter J. Meikle

Diagnosis of Metachromatic Leukodystrophy by Immune Quantification of Arylsulphatase A Protein and Activity in Dried Blood Spots
Clin Chem 2008 54: 1925-1927. [Extract] [Full Text] [PDF]  

Klaus Jung, Azizbek Ramankulov, Mark Schrader, Kurt Miller, and Michael Lein

Circulating Matrix Metalloproteinase-7: An Early or Metastatic Marker for Renal Cell Carcinoma?
Clin Chem 2008 54: 1927-1929. [Extract] [Full Text] [PDF]  

Jasper A. Remijn, Sam Lucas, Bertil Wildeboer, Jeroen D.E. van Suijlen, and Henk J. Adriaansen

Strongly Increased International Normalized Ratio with Recombinant Neoplastin R® Compared with Tissue Extract Neoplastin Plus® in Patients Initiating Oral Anticoagulant Therapy: Implications for Anticoagulation Dosage
Clin Chem 2008 54: 1929-1931. [Extract] [Full Text] [PDF]  

John G. Lewis and Peter A. Elder

Serum 25-OH Vitamin D2 and D3 are Stable under Exaggerated Conditions
Clin Chem 2008 54: 1931-1932. [Extract] [Full Text] [PDF]  

Bookshelf:

Klaus Jung

Tietz Fundamentals of Clinical Chemistry, 6th edition. Carl A. Burtis, Edward R. Ashwood, and David E. Bruns, editors. St Louis, MO: Saunders/Elsevier, 2008, 976 pp, $96.95. ISBN 978-0-7216-3865-2.
Clin Chem 2008 54: 1933. [Extract] [Full Text] [PDF]  

Oak Ridge Conference:

Oak Ridge Conference Poster Abstracts
Clin Chem 2008 54: 1934. [Extract] [Full Text] [PDF] 2008 Poster Abstracts  

Preamble:

Eleftherios P. Diamandis, Barry R. Hoffman, and Catharine M. Sturgeon

National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines for the Use of Tumor Markers
Clin Chem 2008 54: 1935-1939. Published online September 18, 2008; 10.1373/clinchem.2008.105494 [Extract] [Full Text] [PDF] Supplemental Data  

Clinical Chemist:

Who Says Learning Toxicology Can’t Be Fun?
Clin Chem 2008 54: 1940. [Extract] [Full Text] [PDF]  

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