Special Reports:

Catharine M. Sturgeon, Michael J. Duffy, Ulf-Håkan Stenman, Hans Lilja, Nils Brünner, Daniel W. Chan, Richard Babaian, Robert C. Bast, Jr., Barry Dowell, Francisco J. Esteva, Caj Haglund, Nadia Harbeck, Daniel F. Hayes, Mads Holten-Andersen, George G. Klee, Rolf Lamerz, Leendert H. Looijenga, Rafael Molina, Hans Jørgen Nielsen, Harry Rittenhouse, Axel Semjonow, Ie-Ming Shih, Paul Sibley, György Sölétormos, Carsten Stephan, Lori Sokoll, Barry R. Hoffman, and Eleftherios P. Diamandis

National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines for Use of Tumor Markers in Testicular, Prostate, Colorectal, Breast, and Ovarian Cancers
Clin Chem 2008 54: 11-79. [Abstract] [Full Text] [PDF] Supplemental Data  

Editorials:

William A. Gahl

Newborn Screening for Wilson Disease: Does Liquid Chromatography–Tandem Mass Spectrometry Provide the Solution?
Clin Chem 2008 54: 1941-1942. [Extract] [Full Text] [PDF]  

Michael D. Hill

What Kind of Stroke Is It?
Clin Chem 2008 54: 1943-1944. [Extract] [Full Text] [PDF]  

Perspectives:

Borislav Starcevic and Anthony W. Butch

Genetic Variations in UDP-Glucuronosyl Transferase 2B17: Implications for Testosterone Excretion Profiling and Doping Control Programs
Clin Chem 2008 54: 1945-1947. Published online October 16, 2008; 10.1373/clinchem.2008.110106 [Extract] [Full Text] [PDF]  

Connie M. Westhoff and Steven R. Sloan

Molecular Genotyping in Transfusion Medicine
Clin Chem 2008 54: 1948-1950. Published online October 16, 2008; 10.1373/clinchem.2008.116038 [Extract] [Full Text] [PDF]  

Review:

Girish Sardana, Barry Dowell, and Eleftherios P. Diamandis

Emerging Biomarkers for the Diagnosis and Prognosis of Prostate Cancer
Clin Chem 2008 54: 1951-1960. Published online October 16, 2008; 10.1373/clinchem.2008.110668 [Abstract] [Full Text] [PDF]  

Proteomics and Protein Markers:

Amy deWilde, Katerina Sadilkova, Martin Sadilek, Valeria Vasta, and Si Houn Hahn

Tryptic Peptide Analysis of Ceruloplasmin in Dried Blood Spots Using Liquid Chromatography–Tandem Mass Spectrometry: Application to Newborn Screening
Clin Chem 2008 54: 1961-1968. Published online October 9, 2008; 10.1373/clinchem.2008.111989 [Abstract] [Full Text] [PDF] Supplemental Data  

Lipids, Lipoproteins, and Cardiovascular Risk Factors:

Mads Nybo, Søren P. Johnsen, Claus Dethlefsen, Kim Overvad, Anne Tjønneland, Jens Otto L. Jørgensen, and Lars Melholt Rasmussen

Lack of Observed Association between High Plasma Osteoprotegerin Concentrations and Ischemic Stroke Risk in a Healthy Population
Clin Chem 2008 54: 1969-1974. Published online October 30, 2008; 10.1373/clinchem.2008.110593 [Abstract] [Full Text] [PDF]  

Emmanouil S. Brilakis, Amit Khera, Bilal Saeed, Subhash Banerjee, Darren K. McGuire, Sabina A. Murphy, and James A. de Lemos

Association of Lipoprotein-Associated Phospholipase A₂ Mass and Activity with Coronary and Aortic Atherosclerosis: Findings from the Dallas Heart Study
Clin Chem 2008 54: 1975-1981. Published online October 2, 2008; 10.1373/clinchem.2008.107359 [Abstract] [Full Text] [PDF]  

Animal Clinical Chemistry:

Fred S. Apple, MaryAnn M. Murakami, Ranka Ler, Dana Walker, Malcolm York for the HESI Technical Committee of Biomarkers Working Group on Cardiac Troponins

Analytical Characteristics of Commercial Cardiac Troponin I and T Immunoassays in Serum from Rats, Dogs, and Monkeys with Induced Acute Myocardial Injury
Clin Chem 2008 54: 1982-1989. Published online October 9, 2008; 10.1373/clinchem.2007.097568 [Abstract] [Full Text] [PDF] Supplemental Data  

Automation and Analytical Techniques:

Pieter E.M. De Pauw, Ilse Vermeulen, Ogonnaya C. Ubani, Inge Truyen, Evilien M.F. Vekens, Farah T. van Genderen, Joeri W. De Grijse, Daniel G. Pipeleers, Chris Van Schravendijk, and Frans K. Gorus

Simultaneous Measurement of Plasma Concentrations of Proinsulin and C-Peptide and Their Ratio with a Trefoil-Type Time-Resolved Fluorescence Immunoassay
Clin Chem 2008 54: 1990-1998. Published online October 9, 2008; 10.1373/clinchem.2008.109710 [Abstract] [Full Text] [PDF] Supplemental Data  

Cancer Diagnostics:

F. H. Jansen, M. Roobol, C. H. Bangma, and R. H. N. van Schaik

Clinical Impact of New Prostate-Specific Antigen WHO Standardization on Biopsy Rates and Cancer Detection
Clin Chem 2008 54: 1999-2006. Published online October 16, 2008; 10.1373/clinchem.2007.102699 [Abstract] [Full Text] [PDF] Supplemental Data  

Jarrod P. Clark, Kristofer W. Munson, Jessie W. Gu, Katarzyna Lamparska-Kupsik, Kevin G. Chan, Jeffrey S. Yoshida, Mark H. Kawachi, Laura E. Crocitto, Timothy G. Wilson, Ziding Feng, and Steven S. Smith

Performance of a Single Assay for Both Type III and Type VI TMPRSS2:ERG Fusions in Noninvasive Prediction of Prostate Biopsy Outcome
Clin Chem 2008 54: 2007-2017. Published online October 23, 2008; 10.1373/clinchem.2008.108845 [Abstract] [Full Text] [PDF] Supplemental Data  

Drug Monitoring and Toxicology:

Teresa R. Gray, Raquel Magri, Diaa M. Shakleya, and Marilyn A. Huestis

Meconium Nicotine and Metabolites by Liquid Chromatography-Tandem Mass Spectrometry: Differentiation of Passive and Nonexposure and Correlation with Neonatal Outcome Measures
Clin Chem 2008 54: 2018-2027. Published online October 9, 2008; 10.1373/clinchem.2008.109173 [Abstract] [Full Text] [PDF] Supplemental Data  

General Clinical Chemistry:

Hans-Åke Lakso, Patrik Appelblad, and Jörn Schneede

Quantification of Methylmalonic Acid in Human Plasma with Hydrophilic Interaction Liquid Chromatography Separation and Mass Spectrometric Detection
Clin Chem 2008 54: 2028-2035. Published online October 9, 2008; 10.1373/clinchem.2007.101253 [Abstract] [Full Text] [PDF] Supplement Data  

Hematology:

François Boemer, Olivier Ketelslegers, Jean-Marc Minon, Vincent Bours, and Roland Schoos

Newborn Screening for Sickle Cell Disease Using Tandem Mass Spectrometry
Clin Chem 2008 54: 2036-2041. Published online October 2, 2008; 10.1373/clinchem.2008.106369 [Abstract] [Full Text] [PDF] Supplemental Data  

Hemostasis and Thrombosis:

Sabine Eichinger, Gregor Hron, Marietta Kollars, and Paul A. Kyrle

Prediction of Recurrent Venous Thromboembolism by Endogenous Thrombin Potential and D-Dimer
Clin Chem 2008 54: 2042-2048. Published online October 23, 2008; 10.1373/clinchem.2008.112243 [Abstract] [Full Text] [PDF]  

Laboratory Management:

Curtis A. Parvin

Assessing the Impact of the Frequency of Quality Control Testing on the Quality of Reported Patient Results
Clin Chem 2008 54: 2049-2054. Published online October 16, 2008; 10.1373/clinchem.2008.113639 [Abstract] [Full Text] [PDF] Supplemental Data  

Brief Communications:

Michael H. Cho, Dawn Ciulla, Barbara J. Klanderman, Benjamin A. Raby, and Edwin K. Silverman

High-Resolution Melting Curve Analysis of Genomic and Whole-Genome Amplified DNA
Clin Chem 2008 54: 2055-2058. Published online October 16, 2008; 10.1373/clinchem.2008.109744 [Abstract] [Full Text] [PDF] HTML Page - index.htslp  

Aila Leino, Ursula Turpeinen, and Pertti Koskinen

Automated Measurement of 25-OH Vitamin D₃ on the Roche Modular E170 Analyzer
Clin Chem 2008 54: 2059-2062. Published online October 16, 2008; 10.1373/clinchem.2008.111732 [Abstract] [Full Text] [PDF]  

Anthony D. Maher, Prasad Patki, John C. Lindon, Elizabeth J. Want, Elaine Holmes, Michael Craggs, and Jeremy K. Nicholson

Seminal Oligouridinosis: Low Uridine Secretion as a Biomarker for Infertility in Spinal Neurotrauma
Clin Chem 2008 54: 2063-2066. Published online October 2, 2008; 10.1373/clinchem.2008.112219 [Abstract] [Full Text] [PDF]  

Sophie Blanchard, Martin Sadilek, C. Ronald Scott, Frantisek Turecek, and Michael H. Gelb

Tandem Mass Spectrometry for the Direct Assay of Lysosomal Enzymes in Dried Blood Spots: Application to Screening Newborns for Mucopolysaccharidosis I
Clin Chem 2008 54: 2067-2070. Published online October 16, 2008; 10.1373/clinchem.2008.115410 [Abstract] [Full Text] [PDF] Supplemental Data HTML Page - index.htslp  

Clinical Case Study:

Nichole L. Korpi-Steiner, Jonathan B. Hoyne, James D. Hoyer, and Amy K. Saenger

Hemolytic Anemia Following Attempted Suicide
Clin Chem 2008 54: 2071-2074. [Extract] [Full Text] [PDF]  

Ernest Beutler

Commentary
Clin Chem 2008 54: 2074-2075. [Extract] [Full Text] [PDF]  

Ian D. Watson

Commentary
Clin Chem 2008 54: 2075. [Extract] [Full Text] [PDF]  

Citation Classic:

Ronald J. Sawchuk

Liquid-Chromatographic Determination of Cyclosporin A in Blood and Plasma
Clin Chem 2008 54: 2076-2077. [Extract] [Full Text] [PDF]  

Letters to the Editor:

C.M. Cobbaert, C.W. Weykamp, E.C.H.J. Michielsen, H. Baadenhuijsen, and M.P. van Dieijen-Visser

Time-Dependent Instability of Cardiac Troponins in Human Plasma Spiked with NIST Reference Material 2921
Clin Chem 2008 54: 2078-2079. [Extract] [Full Text] [PDF]  

Ji-Seon Jeong, Ha-Jeong Kwon, Yong-Moon Lee, Hye-Ran Yoon, and Seon-Pyo Hong

Galactosemia Screening by Simultaneous Blood Spot Quantification of Galactose and Galactose 1-Phosphate
Clin Chem 2008 54: 2080-2082. [Extract] [Full Text] [PDF]  

Alexandra Marie Yates, Ann Bowron, Lisa Calton, Joanne Heynes, Helen Field, Sandra Rainbow, and Brian Keevil

Interlaboratory Variation in 25-Hydroxyvitamin D₂ and 25-Hydroxyvitamin D₃ Is Significantly Improved If Common Calibration Material Is Used
Clin Chem 2008 54: 2082-2084. [Extract] [Full Text] [PDF]  

Saul A. Datwyler, Stephen C. Hsu, Matthew S. Matias, David P. Pacenti, and Jessie Shih

Potential Interference by Antineutrophil Cytoplasmic Autoantibodies in Myeloperoxidase Immunoassays
Clin Chem 2008 54: 2084-2086. [Extract] [Full Text] [PDF]  

James D. Otvos, Lawrence L. Rudel, and Joseph P. McConnell

Concerns Regarding Lipoprotein Particle Measurement by Ion Mobility Analysis
Clin Chem 2008 54: 2086-2087. [Extract] [Full Text] [PDF]  

Julian Gordon

Protein Microarrays: Before the Elephant Got in the Room
Clin Chem 2008 54: 2087-2088. [Extract] [Full Text] [PDF]  

Michael P. Caulfield, Shuguang Li, Gloria Lee, Patricia A. Blanche, Wael A. Salameh, W. Henry Benner, Richard E. Reitz, and Ronald M. Krauss

In Reply
Clin Chem 2008 54: 2088-2089. [Extract] [Full Text] [PDF]  

Bookshelf:

Jan Ravkilde

Markers in Cardiology: A Case-Orientated Approach. Jesse E. Adams, Fred S. Apple, and Allan S. Jaffe, editors. Malden, MA: Blackwell Futura Publishing, 2007, 261 pp, $99.95. ISBN 978-1-4051-3418-7.
Clin Chem 2008 54: 2090-2091. [Extract] [Full Text] [PDF]  

Clinical Chemist:

J. Thomas Hindmarsh and John Savory

The Death of Napoleon, Cancer or Arsenic?
Clin Chem 2008 54: 2092-2093. [Extract] [Full Text] [PDF]  

Who Says Learning Toxicology Can’t Be Fun?
Clin Chem 2008 54: 2094. [Extract] [Full Text] [PDF]  

Invited Reviewers 2008:

Clinical Chemistry’s Invited Reviewers 2008
Clin Chem 2008 54: 2095-2097. [Extract] [Full Text] [PDF]  

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