Editorials:

Wolfgang Koenig and Christa Meisinger

Uric Acid, Type 2 Diabetes, and Cardiovascular Diseases: Fueling the Common Soil Hypothesis?
Clin Chem 2008 54: 231-233. [Extract] [Full Text] [PDF]  

Paul M Ridker

High-Sensitivity C-Reactive Protein as a Predictor of All-Cause Mortality: Implications for Research and Patient Care
Clin Chem 2008 54: 234-237. [Extract] [Full Text] [PDF]  

James C. Boyd

Cautions in the Adoption of Common Reference Intervals
Clin Chem 2008 54: 238-239. [Extract] [Full Text] [PDF]  

Special Reports:

Cas Weykamp, W Garry John, Andrea Mosca, Tadao Hoshino, Randie Little, Jan-Olof Jeppsson, Ian Goodall, Kor Miedema, Gary Myers, Hans Reinauer, David B. Sacks, Robbert Slingerland, and Carla Siebelder

The IFCC Reference Measurement System for HbA_1c: A 6-Year Progress Report
Clin Chem 2008 54: 240-248. [Abstract] [Full Text] [PDF]  

Paul M Ridker, Daniel I. Chasman, Robert Y.L. Zee, Alex Parker, Lynda Rose, Nancy R. Cook, Julie E Buring for the Women’s Genome Health Study Working Group

Rationale, Design, and Methodology of the Women’s Genome Health Study: A Genome-Wide Association Study of More Than 25 000 Initially Healthy American Women
Clin Chem 2008 54: 249-255. Published online December 10, 2007; 10.1373/clinchem.2007.099366 [Abstract] [Full Text] [PDF]  

Reviews:

Andrew A. Palladino, Michael J. Bennett, and Charles A. Stanley

Hyperinsulinism in Infancy and Childhood: When an Insulin Level Is Not Always Enough
Clin Chem 2008 54: 256-263. Published online December 21, 2007; 10.1373/clinchem.2007.098988 [Abstract] [Full Text] [PDF]  

John W. McMurdy, Gregory D. Jay, Selim Suner, and Gregory Crawford

Noninvasive Optical, Electrical, and Acoustic Methods of Total Hemoglobin Determination
Clin Chem 2008 54: 264-272. Published online December 10, 2007; 10.1373/clinchem.2007.093948 [Abstract] [Full Text] [PDF]  

Proteomics and Protein Markers:

Wolfgang Koenig, Natalie Khuseyinova, Jens Baumert, and Christa Meisinger

Prospective Study of High-Sensitivity C-Reactive Protein as a Determinant of Mortality: Results from the MONICA/KORA Augsburg Cohort Study, 1984–1998
Clin Chem 2008 54: 335-342. Published online December 21, 2007; 10.1373/clinchem.2007.100271 [Abstract] [Full Text] [PDF]  

Claudia Marsik, Lili Kazemi-Shirazi, Thomas Schickbauer, Stefan Winkler, Christian Joukhadar, Oswald F. Wagner, and Georg Endler

C-Reactive Protein and All-Cause Mortality in a Large Hospital-Based Cohort
Clin Chem 2008 54: 343-349. Published online December 21, 2007; 10.1373/clinchem.2007.091959 [Abstract] [Full Text] [PDF] HTML Page - index.htslp  

Pasquale Florio, Luca Bruni, Carmen De Falco, Gilda Filardi, Michela Torricelli, Fernando M. Reis, Letizia Galleri, Chiara Voltolini, Caterina Bocchi, Vincenzo De Leo, and Felice Petraglia

Evaluation of Endometrial Urocortin Secretion for Prediction of Pregnancy after Intrauterine Insemination
Clin Chem 2008 54: 350-355. Published online December 10, 2007; 10.1373/clinchem.2007.094987 [Abstract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Christopher Wright, Donald Bergstrom, Hongyue Dai, Matthew Marton, Mark Morris, George Tokiwa, Yanqun Wang, and Thomas Fare

Characterization of Globin RNA Interference in Gene Expression Profiling of Whole-Blood Samples
Clin Chem 2008 54: 396-405. Published online December 18, 2007; 10.1373/clinchem.2007.093419 [Abstract] [Full Text] [PDF] HTML Page - index.htslp  

Weston C. Hymas, Wade K. Aldous, Edward W. Taggart, Jeffery B. Stevenson, and David R. Hillyard

Description and Validation of a Novel Real-Time RT-PCR Enterovirus Assay
Clin Chem 2008 54: 406-413. Published online November 26, 2007; 10.1373/clinchem.2007.095414 [Abstract] [Full Text] [PDF]  

Catherine Lofton-Day, Fabian Model, Theo DeVos, Reimo Tetzner, Juergen Distler, Matthias Schuster, Xiaoling Song, Ralf Lesche, Volker Liebenberg, Matthias Ebert, Bela Molnar, Robert Grützmann, Christian Pilarsky, and Andrew Sledziewski

DNA Methylation Biomarkers for Blood-Based Colorectal Cancer Screening
Clin Chem 2008 54: 414-423. Published online December 18, 2007; 10.1373/clinchem.2007.095992 [Abstract] [Full Text] [PDF] HTML Page - index.htslp  

Automation and Analytical Techniques:

Ajay Singh Negi and Ajay Kumar Sood

Electric Field–Enhanced Sensitivity of Grafted Ligands and Receptors
Clin Chem 2008 54: 366-370. Published online December 21, 2007; 10.1373/clinchem.2007.094417 [Abstract] [Full Text] [PDF]  

Willem Kulik, Henk van Lenthe, Femke S. Stet, Riekelt H. Houtkooper, Helena Kemp, Janet E. Stone, Colin G. Steward, Ronald J. Wanders, and Frédéric M. Vaz

Bloodspot Assay Using HPLC–Tandem Mass Spectrometry for Detection of Barth Syndrome
Clin Chem 2008 54: 371-378. Published online December 10, 2007; 10.1373/clinchem.2007.095711 [Abstract] [Full Text] [PDF]  

Lipids, Lipoproteins, and Cardiovascular Risk Factors:

Alexander Strasak, Elfriede Ruttmann, Larry Brant, Cecily Kelleher, Jochen Klenk, Hans Concin, Günter Diem, Karl Pfeiffer, Hanno Ulmer and the VHM&PP Study Group

Serum Uric Acid and Risk of Cardiovascular Mortality: A Prospective Long-Term Study of 83 683 Austrian Men
Clin Chem 2008 54: 273-284. Published online November 26, 2007; 10.1373/clinchem.2007.094425 [Abstract] [Full Text] [PDF]  

Kuo-Liong Chien, Hsiu-Ching Hsu, Ta-Chen Su, Fung-Chang Sung, Ming-Fong Chen, and Yuan-Teh Lee

Lipoprotein(a) and Cardiovascular Disease in Ethnic Chinese: The Chin-Shan Community Cardiovascular Cohort Study
Clin Chem 2008 54: 285-291. Published online December 18, 2007; 10.1373/clinchem.2007.090969 [Abstract] [Full Text] [PDF]  

Renke Maas, Edzard Schwedhelm, Lydia Kahl, Huige Li, Ralf Benndorf, Nicole Lüneburg, Ulrich Förstermann, and Rainer H. Böger

Simultaneous Assessment of Endothelial Function, Nitric Oxide Synthase Activity, Nitric Oxide–Mediated Signaling, and Oxidative Stress in Individuals with and without Hypercholesterolemia
Clin Chem 2008 54: 292-300. Published online December 10, 2007; 10.1373/clinchem.2007.093575 [Abstract] [Full Text] [PDF]  

José Maria Moreno-Navarrete, Francisco José Ortega, Judit Bassols, Antoni Castro, Wifredo Ricart, and José Manuel Fernández-Real

Association of Circulating Lactoferrin Concentration and 2 Nonsynonymous LTF Gene Polymorphisms with Dyslipidemia in Men Depends on Glucose-Tolerance Status
Clin Chem 2008 54: 301-309. Published online December 21, 2007; 10.1373/clinchem.2007.095943 [Abstract] [Full Text] [PDF] HTML Page - index.htslp  

Drug Monitoring and Toxicology:

Erin A. Kolbrich, Ross H. Lowe, and Marilyn A. Huestis

Two-Dimensional Gas Chromatography/Electron-Impact Mass Spectrometry with Cryofocusing for Simultaneous Quantification of MDMA, MDA, HMMA, HMA, and MDEA in Human Plasma
Clin Chem 2008 54: 379-387. Published online December 18, 2007; 10.1373/clinchem.2007.096800 [Abstract] [Full Text] [PDF] HTML Page - index.htslp  

Endocrinology and Metabolism:

Kuo-Liong Chien, Ming-Fong Chen, Hsiu-Ching Hsu, Wei-Tien Chang, Ta-Chen Su, Yuan-Teh Lee, and Frank B. Hu

Plasma Uric Acid and the Risk of Type 2 Diabetes in a Chinese Community
Clin Chem 2008 54: 310-316. Published online December 18, 2007; 10.1373/clinchem.2007.095190 [Abstract] [Full Text] [PDF]  

Gabriele Nagel, Kilian Rapp, Martin Wabitsch, Gisela Büchele, Anja Kroke, Iris Zöllner, Stephan K. Weiland, and Wolfgang Koenig

Prevalence and Cluster of Cardiometabolic Biomarkers in Overweight and Obese Schoolchildren: Results from a Large Survey in Southwest Germany
Clin Chem 2008 54: 317-325. Published online December 18, 2007; 10.1373/clinchem.2007.094821 [Abstract] [Full Text] [PDF] HTML Page - index.htslp  

Linda Dodds, Deshayne B. Fell, Kent C. Dooley, B. Anthony Armson, Alexander C. Allen, Bassam A. Nassar, Sherry Perkins, and K.S. Joseph

Effect of Homocysteine Concentration in Early Pregnancy on Gestational Hypertensive Disorders and Other Pregnancy Outcomes
Clin Chem 2008 54: 326-334. Published online December 10, 2007; 10.1373/clinchem.2007.097469 [Abstract] [Full Text] [PDF]  

General Clinical Chemistry:

Kiyoshi Ichihara, Yoshihisa Itoh, Christopher W. K. Lam, Priscilla M. K. Poon, Jeong-Ho Kim, Hiroshi Kyono, Naning Chandrawening, Dewi Muliaty Science Committee for the Asian-Pacific Federation of Clinical Biochemistry

Sources of Variation of Commonly Measured Serum Analytes in 6 Asian Cities and Consideration of Common Reference Intervals
Clin Chem 2008 54: 356-365. Published online December 18, 2007; 10.1373/clinchem.2007.091843 [Abstract] [Full Text] [PDF]  

Nutrition:

Thierry Charles Coste, Gladys Deumer, Gregory Reychler, Patrick Lebecque, Pierre Wallemacq, and Teresinha Leal

Influence of Pancreatic Status and Sex on Polyunsaturated Fatty Acid Profiles in Cystic Fibrosis
Clin Chem 2008 54: 388-395. Published online December 18, 2007; 10.1373/clinchem.2007.094623 [Abstract] [Full Text] [PDF]  

Brief Communications:

Jung-ah Kwon, Hyeseon Lee, Kap No Lee, Kwangchun Chae, Seram Lee, Dong-ki Lee, and Soyoun Kim

High Diagnostic Accuracy of Antigen Microarray for Sensitive Detection of Hepatitis C Virus Infection
Clin Chem 2008 54: 424-428. [Abstract] [Full Text] [PDF]  

Mikhail Roshal, Jeanne Turgeon, and Petrie M. Rainey

Rapid Quantitative Method Using Spin Columns to Measure Porphobilinogen in Urine
Clin Chem 2008 54: 429-431. [Abstract] [Full Text] [PDF]  

Alex J. Stephens, John Inman-Bamber, Philip M. Giffard, and Flavia Huygens

High-Resolution Melting Analysis of the spa Repeat Region of Staphylococcus aureus
Clin Chem 2008 54: 432-436. [Abstract] [Full Text] [PDF]  

Attie T.J.I. Go, Allerdien Visser, Ofir T. Betsalel, John M.G. van Vugt, Marinus A. Blankenstein, and Cees B.M. Oudejans

Measurement of Allelic-Expression Ratios in Trisomy 21 Placentas by Quencher Extension of Heterozygous Samples Identified by Partially Denaturing HPLC
Clin Chem 2008 54: 437-440. [Abstract] [Full Text] [PDF] HTML Page - index.htslp  

Citation Classics:

Bruce W. Hollis

Phase Switching SPE for Faster 1,25-dihydroxyvitamin D Analysis
Clin Chem 2008 54: 446-447. [Extract] [Full Text] [PDF]  

Clinical Case Study:

Leann M. Mikesh, Sheila E. Crowe, Grant C. Bullock, Nancy E. Taylor, and David E. Bruns

Celiac Disease Refractory to a Gluten-free Diet?
Clin Chem 2008 54: 441-444. [Extract] [Full Text] [PDF]  

Commentaries:

Robin G. Lorenz

Commentary
Clin Chem 2008 54: 444-445. [Extract] [Full Text] [PDF]  

Susan H. Barton and Joseph A. Murray

Commentary
Clin Chem 2008 54: 445. [Extract] [Full Text] [PDF]  

Letters to the Editor:

Paul Collinson, Kari Pulkki, Janne Suvisaari, Jan Ravkilde, Ana Stavljenic-Rukavina, Angelika Hammerer-Lercher, Hannsjörg Baum, Marja P. van Dieijen-Visser, and Paivi H. Laitinen

How Well Do Laboratories Follow Guidelines on Cardiac Markers? The Cardiac Marker Guideline Uptake in Europe Study
Clin Chem 2008 54: 448-449. [Extract] [Full Text] [PDF]  

Boban Abraham, Ijaz Fakhar, Anurag Tikaria, LaDonna Hocutt, Jim Marshall, Sundararaman Swaminathan, and Joshua A. Bornhorst

Reverse Pseudohyperkalemia in a Leukemic Patient
Clin Chem 2008 54: 449-451. [Extract] [Full Text] [PDF]  

Paul D’Orazio, JoAnn Conant, and Jose Cervera

Measurement of Creatinine in Whole Blood Samples Supplemented to Achieve Increased Creatinine Concentrations
Clin Chem 2008 54: 451-452. [Extract] [Full Text] [PDF]  

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