Editorials:

Joseph Emmerich and Paul M Ridker

Can Fishing for New Genes Catch Patients at Risk of Coronary Artery Disease?
Clin Chem 2008 54: 453-455. [Extract] [Full Text] [PDF]  

Cees B. M. Oudejans

Noncoding RNA and DNA as Biomarkers: Toward an Epigenetic Fetal Barcode for Use in Maternal Plasma
Clin Chem 2008 54: 456-457. [Extract] [Full Text] [PDF]  

Ronald S. Swerdloff and Christina Wang

Free Testosterone Measurement by the Analog Displacement Direct Assay: Old Concerns and New Evidence
Clin Chem 2008 54: 458-460. [Extract] [Full Text] [PDF]  

Reviews:

Y. M. Dennis Lo and Rossa W. K. Chiu

Noninvasive Prenatal Diagnosis of Fetal Chromosomal Aneuploidies by Maternal Plasma Nucleic Acid Analysis
Clin Chem 2008 54: 461-466. Published online January 17, 2008; 10.1373/clinchem.2007.100016 [Abstract] [Full Text] [PDF]  

Proteomics and Protein Markers:

Gaiane Sarkissian, Patricia Fergelot, Pierre-Jean Lamy, Jean-Jacques Patard, Stephane Culine, Patrick Jouin, Nathalie Rioux-Leclercq, and Bruno Darbouret

Identification of Pro-MMP-7 as a Serum Marker for Renal Cell Carcinoma by Use of Proteomic Analysis
Clin Chem 2008 54: 574-581. Published online January 17, 2008; 10.1373/clinchem.2007.090837 [Abstract] [Full Text] [PDF]  

Simon Fredriksson, Joe Horecka, Odd Terje Brustugun, Joerg Schlingemann, Albert C. Koong, Rob Tibshirani, and Ronald W. Davis

Multiplexed Proximity Ligation Assays to Profile Putative Plasma Biomarkers Relevant to Pancreatic and Ovarian Cancer
Clin Chem 2008 54: 582-589. Published online January 2, 2008; 10.1373/clinchem.2007.093195 [Abstract] [Full Text] [PDF] HTML Page - index.htslp  

Molecular Diagnostics and Genetics:

Stephen S.C. Chim, Tristan K.F. Shing, Emily C.W. Hung, Tak-yeung Leung, Tze-kin Lau, Rossa W.K. Chiu, and Y.M. Dennis Lo

Detection and Characterization of Placental MicroRNAs in Maternal Plasma
Clin Chem 2008 54: 482-490. Published online January 24, 2008; 10.1373/clinchem.2007.097972 [Abstract] [Full Text] [PDF] HTML Page - index.htslp  

Sara Bruce, Katariina Hannula-Jouppi, Cecilia M. Lindgren, Marita Lipsanen-Nyman, and Juha Kere

Restriction Site–Specific Methylation Studies of Imprinted Genes with Quantitative Real-Time PCR
Clin Chem 2008 54: 491-499. Published online January 17, 2008; 10.1373/clinchem.2007.098491 [Abstract] [Full Text] [PDF] Supplemental Data  

Stephen S.C. Chim, Shengnan Jin, Tracy Y.H. Lee, Fiona M.F. Lun, Wing S. Lee, Lisa Y.S. Chan, Yongjie Jin, Ningning Yang, Yu K. Tong, Tak Y. Leung, Tze K. Lau, Chunming Ding, Rossa W.K. Chiu, and Y.M. Dennis Lo

Systematic Search for Placental DNA-Methylation Markers on Chromosome 21: Toward a Maternal Plasma-Based Epigenetic Test for Fetal Trisomy 21
Clin Chem 2008 54: 500-511. Published online January 17, 2008; 10.1373/clinchem.2007.098731 [Abstract] [Full Text] [PDF] HTML Page - index.htslp  

Lipids, Lipoproteins, and Cardiovascular Risk Factors:

Philippa J. Talmud, Jackie A. Cooper, Jutta Palmen, Ruth Lovering, Fotios Drenos, Aroon D. Hingorani, and Steve E. Humphries

Chromosome 9p21.3 Coronary Heart Disease Locus Genotype and Prospective Risk of CHD in Healthy Middle-Aged Men
Clin Chem 2008 54: 467-474. Published online February 4, 2008; 10.1373/clinchem.2007.095489 [Abstract] [Full Text] [PDF] HTML Page - index.htslp  

Fulvio Lauretani, Richard D. Semba, Stefania Bandinelli, Edgar R. Miller, III, Carmelinda Ruggiero, Antonio Cherubini, Jack M. Guralnik, and Luigi Ferrucci

Plasma Polyunsaturated Fatty Acids and the Decline of Renal Function
Clin Chem 2008 54: 475-481. Published online January 17, 2008; 10.1373/clinchem.2007.095521 [Abstract] [Full Text] [PDF]  

Drug Monitoring and Toxicology:

Huub H. van Rossum, Fred P.H.T.M. Romijn, Kathryn J. Sellar, Nico P.M. Smit, Paul J.M. van der Boog, Johan W. de Fijter, and Johannes van Pelt

Variation in Leukocyte Subset Concentrations Affects Calcineurin Activity Measurement: Implications for Pharmacodynamic Monitoring Strategies
Clin Chem 2008 54: 517-524. Published online January 24, 2008; 10.1373/clinchem.2007.097253 [Abstract] [Full Text] [PDF]  

Endocrinology and Metabolism:

Kristofer S. Fritz, Alastair J.S. McKean, Jerald C. Nelson, and R. Bruce Wilcox

Analog-Based Free Testosterone Test Results Linked to Total Testosterone Concentrations, Not Free Testosterone Concentrations
Clin Chem 2008 54: 512-516. Published online January 2, 2008; 10.1373/clinchem.2007.094870 [Abstract] [Full Text] [PDF]  

General Clinical Chemistry:

Ferruccio Ceriotti, James C. Boyd, Gerhard Klein, Joseph Henny, Josep Queraltó, Veli Kairisto, Mauro Panteghini on behalf of the IFCC Committee on Reference Intervals and Decision Limits (C-RIDL)

Reference Intervals for Serum Creatinine Concentrations: Assessment of Available Data for Global Application
Clin Chem 2008 54: 559-566. Published online January 17, 2008; 10.1373/clinchem.2007.099648 [Abstract] [Full Text] [PDF] HTML Page - index.htslp  

Jeff Brady, Lesley Wilson, Lynda McGregor, Edward Valente, and Lars Orning

Active B12: A Rapid, Automated Assay for Holotranscobalamin on the Abbott AxSYM Analyzer
Clin Chem 2008 54: 567-573. Published online January 4, 2008; 10.1373/clinchem.2007.096784 [Abstract] [Full Text] [PDF] HTML Page - index.htslp  

Clinical Immunology:

Sandra Szameit, Klemens Vierlinger, Letizia Farmer, Helga Tuschl, and Christa Noehammer

Microarray-Based In Vitro Test System for the Discrimination of Contact Allergens and Irritants: Identification of Potential Marker Genes
Clin Chem 2008 54: 525-533. Published online January 17, 2008; 10.1373/clinchem.2007.097386 [Abstract] [Full Text] [PDF] HTML Page - index.htslp HTML Page - index.htslp  

Nathalie Vermeulen, Ingrid Arijs, Sofie Joossens, Severine Vermeire, Stefan Clerens, Karolien Van den Bergh, Georges Michiels, Lutgarde Arckens, Frans Schuit, Leentje Van Lommel, Paul Rutgeerts, and Xavier Bossuyt

Anti–-enolase Antibodies in Patients with Inflammatory Bowel Disease
Clin Chem 2008 54: 534-541. Published online January 24, 2008; 10.1373/clinchem.2007.098368 [Abstract] [Full Text] [PDF] HTML Page - index.htslp  

Pediatric Clinical Chemistry:

Devin Oglesbee, Karen A. Sanders, Jean M. Lacey, Mark J. Magera, Bruno Casetta, Kevin A. Strauss, Silvia Tortorelli, Piero Rinaldo, and Dietrich Matern

Second-Tier Test for Quantification of Alloisoleucine and Branched-Chain Amino Acids in Dried Blood Spots to Improve Newborn Screening for Maple Syrup Urine Disease (MSUD)
Clin Chem 2008 54: 542-549. Published online January 4, 2008; 10.1373/clinchem.2007.098434 [Abstract] [Full Text] [PDF]  

Claudio Chiesa, John F. Osborn, Cristina Haass, Fabio Natale, Marina Spinelli, Eleonora Scapillati, Angela Spinelli, and Lucia Pacifico

Ghrelin, Leptin, IGF-1, IGFBP-3, and Insulin Concentrations at Birth: Is There a Relationship with Fetal Growth and Neonatal Anthropometry?
Clin Chem 2008 54: 550-558. Published online January 17, 2008; 10.1373/clinchem.2007.095299 [Abstract] [Full Text] [PDF]  

Brief Communications:

Bingfang Yue, Elizabeth Pattison, William L. Roberts, Alan L. Rockwood, Oliver Danne, Christian Lueders, and Martin Möckel

Choline in Whole Blood and Plasma: Sample Preparation and Stability
Clin Chem 2008 54: 590-593. [Abstract] [Full Text] [PDF] HTML Page - index.htslp  

Berndt Zur, Andreas Hornung, Johannes Breuer, Ulrike Doll, Christine Bernhardt, Michael Ludwig, and Birgit Stoffel-Wagner

A Novel Hemoglobin, Bonn, Causes Falsely Decreased Oxygen Saturation Measurements in Pulse Oximetry
Clin Chem 2008 54: 594-596. [Abstract] [Full Text] [PDF]  

Johnny Gutierrez, Gottfried E. Konecny, Kyu Hong, Alexander Burges, Timothy D. Henry, Pier D. Lambiase, Wai Lee Wong, and Y. Gloria Meng

A New ELISA for Use in a 3-ELISA System to Assess Concentrations of VEGF Splice Variants and VEGF₁₁₀ in Ovarian Cancer Tumors
Clin Chem 2008 54: 597-601. [Abstract] [Full Text] [PDF] HTML Page - index.htslp  

Ute Holtkamp, Jeanette Klein, Johannes Sander, Michael Peter, Nils Janzen, Ulrike Steuerwald, and Oliver Blankenstein

EDTA in Dried Blood Spots Leads to False Results in Neonatal Endocrinologic Screening
Clin Chem 2008 54: 602-605. [Abstract] [Full Text] [PDF] HTML Page - index.htslp  

Citation Classics:

James O. Westgard

Use and Interpretation of Common Statistical Tests in Method Comparison Studies
Clin Chem 2008 54: 612. [Extract] [Full Text] [PDF]  

Inspiring Minds:

Misia Landau

Jack Ladenson
Clin Chem 2008 54: 613-614. [Extract] [Full Text] [PDF] HTML Page - index.htslp  

Clinical Case Study:

Amit R. Rahalkar, Jian Wang, Sandra Sirrs, James Dimmick, Daniel Holmes, Nadine Urquhart, Robert A. Hegele, and Andre Mattman

An Unusual Case of Severe Hypertriglyceridemia and Splenomegaly
Clin Chem 2008 54: 606-610. [Extract] [Full Text] [PDF]  

Commentaries:

Alan T. Remaley

Commentary
Clin Chem 2008 54: 610-611. [Extract] [Full Text] [PDF]  

Robert Shamburek

Commentary
Clin Chem 2008 54: 611. [Extract] [Full Text] [PDF]  

Letters to the Editor:

Radha Ramachandran, Michael Patterson, Kevin G. Murphy, Waljit S. Dhillo, Sejal Patel, Anna Kazarian, Mohammad A. Ghatei, and Stephen R. Bloom

Preanalytical Factors Affecting RIA Measurement of Plasma Kisspeptin
Clin Chem 2008 54: 615-617. [Extract] [Full Text] [PDF]  

Vlad C. Vasile, Luciano Babuin, Evangelos Giannitsis, Hugo A. Katus, and Allan S. Jaffe

Relationship of MRI-Determined Infarct Size and cTnI Measurements in Patients with ST-Elevation Myocardial Infarction
Clin Chem 2008 54: 617-619. [Extract] [Full Text] [PDF]  

Kristin N. Luckenbill, Robert H. Christenson, Allan S. Jaffe, Johannes Mair, Jordi Ordonez-Llanos, Franca Pagani, Jillian Tate, Alan H. B. Wu, Ranka Ler, and Fred S. Apple

Cross-Reactivity of BNP, NT-proBNP, and proBNP in Commercial BNP and NT-proBNP Assays: Preliminary Observations from the IFCC Committee for Standardization of Markers of Cardiac Damage
Clin Chem 2008 54: 619-621. [Extract] [Full Text] [PDF]  

Takashi Nanba, Mikio Watanabe, Takashi Akamizu, and Yoshinori Iwatani

The –590CC Genotype in the IL4 Gene as a Strong Predictive Factor for the Development of Hypothyroidism in Hashimoto Disease
Clin Chem 2008 54: 621-623. [Extract] [Full Text] [PDF]  

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