Editorials:

Linda M. Thienpont

A Major Step Forward in the Routine Measurement of Serum Free Thyroid Hormones
Clin Chem 2008 54: 625-626. [Extract] [Full Text] [PDF]  

Kenneth A. Pass and Mark Morrissey

Enhancing Newborn Screening for Tyrosinemia Type I
Clin Chem 2008 54: 627-629. [Extract] [Full Text] [PDF]  

Perspective:

Graham Beastall and Sandra Rainbow

Vitamin D Reinvented: Implications for Clinical Chemistry
Clin Chem 2008 54: 630-632. [Extract] [Full Text] [PDF]  

Review:

Keith Hyland

Clinical Utility of Monoamine Neurotransmitter Metabolite Analysis in Cerebrospinal Fluid
Clin Chem 2008 54: 633-641. Published online February 29, 2008; 10.1373/clinchem.2007.099986 [Abstract] [Full Text] [PDF]  

Endocrinology and Metabolism:

Bingfang Yue, Alan L. Rockwood, Tanya Sandrock, Sonia L. La’ulu, Mark M. Kushnir, and A. Wayne Meikle

Free Thyroid Hormones in Serum by Direct Equilibrium Dialysis and Online Solid-Phase Extraction–Liquid Chromatography/Tandem Mass Spectrometry
Clin Chem 2008 54: 642-651. Published online February 7, 2008; 10.1373/clinchem.2007.098293 [Abstract] [Full Text] [PDF] Supplemental Data  

Ann M. Gronowski, Corinne R. Fantz, Curtis A. Parvin, Lori J. Sokoll, Carmen L. Wiley, Mark H. Wener, and David G. Grenache

Use of Serum FSH to Identify Perimenopausal Women with Pituitary hCG
Clin Chem 2008 54: 652-656. Published online February 7, 2008; 10.1373/clinchem.2007.100305 [Abstract] [Full Text] [PDF] Supplemental Data  

Pediatric Clinical Chemistry:

Coleman Turgeon, Mark J. Magera, Pierre Allard, Silvia Tortorelli, Dimitar Gavrilov, Devin Oglesbee, Kimiyo Raymond, Piero Rinaldo, and Dietrich Matern

Combined Newborn Screening for Succinylacetone, Amino Acids, and Acylcarnitines in Dried Blood Spots
Clin Chem 2008 54: 657-664. Published online February 15, 2008; 10.1373/clinchem.2007.101949 [Abstract] [Full Text] [PDF] Supplemental Data  

Automation and Analytical Techniques:

Rita Hannisdal, Asbjørn Svardal, and Per Magne Ueland

Measurement of Folate in Fresh and Archival Serum Samples as p-Aminobenzoylglutamate Equivalents
Clin Chem 2008 54: 665-672. Published online February 15, 2008; 10.1373/clinchem.2007.100511 [Abstract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Masato Mitsuhashi, Katsuya Endo, Kazuhiko Obara, Hiroshi Izutsu, Taishi Ishida, Norio Chikatsu, and Atsushi Shinagawa

Ex Vivo Simulation of the Action of Antileukemia Drugs by Measuring Apoptosis-Related mRNA in Blood
Clin Chem 2008 54: 673-681. Published online February 21, 2008; 10.1373/clinchem.2007.091975 [Abstract] [Full Text] [PDF]  

Stephan Waldmüller, Melanie Müller, Kirsten Rackebrandt, Priska Binner, Sven Poths, Michael Bonin, and Thomas Scheffold

Array-Based Resequencing Assay for Mutations Causing Hypertrophic Cardiomyopathy
Clin Chem 2008 54: 682-687. Published online February 7, 2008; 10.1373/clinchem.2007.099119 [Abstract] [Full Text] [PDF] Supplemental Data  

Imke Müller, Cord Beeger, Catherine Alix-Panabières, Xavier Rebillard, Klaus Pantel, and Heidi Schwarzenbach

Identification of Loss of Heterozygosity on Circulating Free DNA in Peripheral Blood of Prostate Cancer Patients: Potential and Technical Improvements
Clin Chem 2008 54: 688-696. Published online February 15, 2008; 10.1373/clinchem.2007.099333 [Abstract] [Full Text] [PDF] Supplemental Data  

Maria Papp, Ildiko Foldi, Eva Nemes, Miklos Udvardy, Jolan Harsfalvi, Istvan Altorjay, Istvan Mate, Tamas Dinya, Csaba Varvolgyi, Zsolt Barta, Gabor Veres, Peter Laszlo Lakatos, Judit Tumpek, Laszlo Toth, Erzsebet Szathmari, Aniko Kapitany, Agnes Gyetvai, and Ilma R. Korponay-Szabo

Haptoglobin Polymorphism: A Novel Genetic Risk Factor for Celiac Disease Development and Its Clinical Manifestations
Clin Chem 2008 54: 697-704. Published online February 7, 2008; 10.1373/clinchem.2007.098780 [Abstract] [Full Text] [PDF]  

Drug Monitoring and Toxicology:

Wei Zhu, Dan Wang, Jiaohong Zheng, Yarui An, Qingjiang Wang, Wen Zhang, Litong Jin, Hongying Gao, and Longnian Lin

Effect of (R)-Salsolinol and N-Methyl-(R)-Salsolinol on the Balance Impairment Between Dopamine and Acetylcholine in Rat Brain: Involvement in Pathogenesis of Parkinson Disease
Clin Chem 2008 54: 705-712. Published online January 31, 2008; 10.1373/clinchem.2007.097725 [Abstract] [Full Text] [PDF] Supplemental Data  

Proteomics and Protein Markers:

Vladimir Petrik, Samira Saadoun, Alison Loosemore, Josie Hobbs, Kirstie S. Opstad, Joanna Sheldon, Edward Tarelli, Franklyn A. Howe, B. Anthony Bell, and Marios C. Papadopoulos

Serum ₂-HS Glycoprotein Predicts Survival in Patients with Glioblastoma
Clin Chem 2008 54: 713-722. Published online February 15, 2008; 10.1373/clinchem.2007.096792 [Abstract] [Full Text] [PDF]  

Fred S. Apple, Stephen W. Smith, Lesly A. Pearce, Ranka Ler, and MaryAnn M. Murakami

Use of the Centaur TnI-Ultra Assay for Detection of Myocardial Infarction and Adverse Events in Patients Presenting With Symptoms Suggestive of Acute Coronary Syndrome
Clin Chem 2008 54: 723-728. Published online January 31, 2008; 10.1373/clinchem.2007.097162 [Abstract] [Full Text] [PDF]  

Informatics and Statistics:

Mariska M.G. Leeflang, Karel G.M. Moons, Johannes B. Reitsma, and Aielko H. Zwinderman

Bias in Sensitivity and Specificity Caused by Data-Driven Selection of Optimal Cutoff Values: Mechanisms, Magnitude, and Solutions
Clin Chem 2008 54: 729-737. Published online February 7, 2008; 10.1373/clinchem.2007.096032 [Abstract] [Full Text] [PDF]  

Lipids, Lipoproteins, and Cardiovascular Risk Factors:

Bharat Thyagarajan, David R. Jacobs, Jr., J. Jeffery Carr, Ogechika Alozie, Michael W. Steffes, Poonguzhali Kailash, Jennifer H. Hayes, and Myron D. Gross

Factors Associated with Paraoxonase Genotypes and Activity in a Diverse, Young, Healthy Population: The Coronary Artery Risk Development in Young Adults (CARDIA) Study
Clin Chem 2008 54: 738-746. Published online February 15, 2008; 10.1373/clinchem.2007.099044 [Abstract] [Full Text] [PDF]  

Brief Communications:

Peter A. Kavsak, Alice M. Newman, Dennis T. Ko, Glenn E. Palomaki, Viliam Lustig, Andrew R. MacRae, and Allan S. Jaffe

Is a Pattern of Increasing Biomarker Concentrations Important for Long-Term Risk Stratification in Acute Coronary Syndrome Patients Presenting Early after the Onset of Symptoms?
Clin Chem 2008 54: 747-751. [Abstract] [Full Text] [PDF]  

Thomas Mueller, Benjamin Dieplinger, Alfons Gegenhuber, Werner Poelz, Richard Pacher, and Meinhard Haltmayer

Increased Plasma Concentrations of Soluble ST2 are Predictive for 1-Year Mortality in Patients with Acute Destabilized Heart Failure
Clin Chem 2008 54: 752-756. [Abstract] [Full Text] [PDF] Supplemental Data  

Ruth E. Board, Nicola J. Thelwell, Paul F. Ravetto, Stephen Little, Malcolm Ranson, Caroline Dive, Andrew Hughes, and David Whitcombe

Multiplexed Assays for Detection of Mutations in PIK3CA
Clin Chem 2008 54: 757-760. [Abstract] [Full Text] [PDF]  

Zhimin (Tim) Cao and Robert Rej

Are Laboratories Reporting Serum Quantitative hCG Results Correctly?
Clin Chem 2008 54: 761-764. [Abstract] [Full Text] [PDF]  

Clinical Case Study:

Joshua L. Hood and Charles S. Eby

Evaluation of a Prolonged Prothrombin Time
Clin Chem 2008 54: 765-768. [Extract] [Full Text] [PDF]  

Sandra C. Hollensead

Commentary
Clin Chem 2008 54: 768-769. [Extract] [Full Text] [PDF]  

Elizabeth M. Van Cott

Commentary
Clin Chem 2008 54: 769. [Extract] [Full Text] [PDF]  

Citation Classics:

Michael A. Pesce

Quantifying Protein in Cerebrospinal Fluid and Urine: Success Achieved
Clin Chem 2008 54: 770. [Extract] [Full Text] [PDF]  

Letters to the Editor:

María Fatás, Pablo Franquelo, and Ricardo Franquelo

Anomalous Flotation of Separator Gel: Density or Viscosity?
Clin Chem 2008 54: 771-772. [Extract] [Full Text] [PDF]  

Klaus Jung, Silke Klotzek, Carsten Stephan, Ferdinando Mannello, and Michael Lein

Impact of Blood Sampling on the Circulating Matrix Metalloproteinases 1, 2, 3, 7, 8, and 9
Clin Chem 2008 54: 772-773. [Extract] [Full Text] [PDF]  

Sam Orr

Analysis of Urine Benzodiazepines with the Abbott Multigent^TM Reagents
Clin Chem 2008 54: 774. [Extract] [Full Text] [PDF]  

Book, Software, and Web Site Reviews:

Glen L. Hortin

Proteomics of Human Body Fluids. Visith Thongboonkerd, Editor., Totowa, NJ: Humana Press, 2007, 533 pp. (hardcover). ISBN 978-1-59745-432-2.
Clin Chem 2008 54: 775. [Extract] [Full Text] [PDF]  

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