Editorials:

Michael G. Kattah, Paul J. Utz, and Imelda Balboni

Protein Microarrays Address the Elephant in the Room
Clin Chem 2008 54: 937-939. [Extract] [Full Text] [PDF]  

Perspectives:

Evan A. Stein

After ENHANCE: Is More LDL Cholesterol Lowering Even Better?
Clin Chem 2008 54: 940-942. Published online April 10, 2008; 10.1373/clinchem.2008.104893 [Extract] [Full Text] [PDF]  

Scott A. Waldman and Andre Terzic

MicroRNA Signatures as Diagnostic and Therapeutic Targets
Clin Chem 2008 54: 943-944. [Extract] [Full Text] [PDF]  

Review:

Sarah de Ferranti and Dariush Mozaffarian

The Perfect Storm: Obesity, Adipocyte Dysfunction, and Metabolic Consequences
Clin Chem 2008 54: 945-955. Published online April 24, 2008; 10.1373/clinchem.2007.100156 [Abstract] [Full Text] [PDF]  

Automation and Analytical Techniques:

Michael Hartmann, Monika Schrenk, Anette Döttinger, Sarah Nagel, Johan Roeraade, Thomas O. Joos, and Markus F. Templin

Expanding Assay Dynamics: A Combined Competitive and Direct Assay System for the Quantification of Proteins in Multiplexed Immunoassays
Clin Chem 2008 54: 956-963. Published online April 24, 2008; 10.1373/clinchem.2007.099812 [Abstract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Clara R. L. Teo, Wen Wang, Hai Yang Law, Caroline G. Lee, and Samuel S. Chong

Single-Step Scalable-Throughput Molecular Screening for Huntington Disease
Clin Chem 2008 54: 964-972. Published online April 10, 2008; 10.1373/clinchem.2007.096503 [Abstract] [Full Text] [PDF] Supplemental Data  

Amelia Trimarco, Annalaura Torella, Giulio Piluso, Vega Maria Ventriglia, Luisa Politano, and Vincenzo Nigro

Log-PCR: A New Tool for Immediate and Cost-Effective Diagnosis of up to 85% of Dystrophin Gene Mutations
Clin Chem 2008 54: 973-981. Published online April 10, 2008; 10.1373/clinchem.2007.097881 [Abstract] [Full Text] [PDF] Supplemental Data  

Kim De Leeneer, Ilse Coene, Bruce Poppe, Anne De Paepe, and Kathleen Claes

Rapid and Sensitive Detection of BRCA1/2 Mutations in a Diagnostic Setting: Comparison of Two High-Resolution Melting Platforms
Clin Chem 2008 54: 982-989. Published online April 10, 2008; 10.1373/clinchem.2007.098764 [Abstract] [Full Text] [PDF] Supplemental Data  

Genevieve Pont-Kingdon, Rebecca L. Margraf, Kelli Sumner, Alison Millson, Elaine Lyon, and Ekkehard Schütz

Design and Application of Noncontinuously Binding Probes Used for Haplotyping and Genotyping
Clin Chem 2008 54: 990-999. Published online April 10, 2008; 10.1373/clinchem.2007.100487 [Abstract] [Full Text] [PDF] Supplemental Data  

Katri Saukkonen, Päivi Lakkisto, Ville Pettilä, Marjut Varpula, Sari Karlsson, Esko Ruokonen, Kari Pulkki for the Finnsepsis Study Group

Cell-Free Plasma DNA as a Predictor of Outcome in Severe Sepsis and Septic Shock
Clin Chem 2008 54: 1000-1007. Published online April 17, 2008; 10.1373/clinchem.2007.101030 [Abstract] [Full Text] [PDF] Supplemental Data  

Drug Monitoring and Toxicology:

Robert W. Siegel, Wade Baugher, Tanya Rahn, Susan Drengler, and Joan Tyner

Affinity Maturation of Tacrolimus Antibody for Improved Immunoassay Performance
Clin Chem 2008 54: 1008-1017. Published online April 10, 2008; 10.1373/clinchem.2007.097352 [Abstract] [Full Text] [PDF] Supplemental Data  

Endocrinology and Metabolism:

Patricia Kaiser, Theodorus Akerboom, Petra Molnar, and Hans Reinauer

Modified HPLC-Electrospray Ionization/Mass Spectrometry Method for HbA_1c Based on IFCC Reference Measurement Procedure
Clin Chem 2008 54: 1018-1022. Published online April 10, 2008; 10.1373/clinchem.2007.100875 [Abstract] [Full Text] [PDF] Supplemental Data  

Randie R. Little, Curt L. Rohlfing, Alethea L. Tennill, Richard W. Madsen, Kenneth S. Polonsky, Gary L. Myers, Carla J. Greenbaum, Jerry P. Palmer, Eduard Rogatsky, and Daniel T. Stein

Standardization of C-Peptide Measurements
Clin Chem 2008 54: 1023-1026. Published online April 17, 2008; 10.1373/clinchem.2007.101287 [Abstract] [Full Text] [PDF] Supplemental Data  

Lipids, Lipoproteins, and Cardiovascular Risk Factors:

Alyson Kelley-Hedgepeth, Donald M. Lloyd-Jones, Alicia Colvin, Karen A. Matthews, Janet Johnston, MaryFran R. Sowers, Barbara Sternfeld, Richard C. Pasternak, Claudia U. Chae for the SWAN Investigators

Ethnic Differences in C-Reactive Protein Concentrations
Clin Chem 2008 54: 1027-1037. Published online April 10, 2008; 10.1373/clinchem.2007.098996 [Abstract] [Full Text] [PDF]  

Gilles Lambert, Nicolas Ancellin, Francesca Charlton, Daniel Comas, Julia Pilot, Anthony Keech, Sanjay Patel, David R. Sullivan, Jeffrey S. Cohn, Kerry-Anne Rye, and Philip J. Barter

Plasma PCSK9 Concentrations Correlate with LDL and Total Cholesterol in Diabetic Patients and Are Decreased by Fenofibrate Treatment
Clin Chem 2008 54: 1038-1045. Published online April 24, 2008; 10.1373/clinchem.2007.099747 [Abstract] [Full Text] [PDF] Supplemental Data  

Xiaomin Zhang, Mei-An He, Longxian Cheng, Li Zhou, Hesong Zeng, Jing Wang, Feng Wang, Ying Chen, Frank B. Hu, and Tangchun Wu

Joint Effects of Antibody to Heat Shock Protein 60, Hypertension, and Diabetes on Risk of Coronary Heart Disease in Chinese
Clin Chem 2008 54: 1046-1052. Published online April 24, 2008; 10.1373/clinchem.2007.101451 [Abstract] [Full Text] [PDF]  

Hematology:

Isabelle Zanella-Cleon, Michel Becchi, Philippe Lacan, Piero C. Giordano, Henri Wajcman, and Alain Francina

Detection of a Thalassemic -Chain Variant (Hemoglobin Groene Hart) by Reversed-Phase Liquid Chromatography
Clin Chem 2008 54: 1053-1059. Published online April 17, 2008; 10.1373/clinchem.2007.097857 [Abstract] [Full Text] [PDF] Supplemental Data  

Hemostasis and Thrombosis:

Brad S. Karon, Amy Wockenfus, Renee Scott, Stacy J. Hartman, Joseph P. McConnell, Paula J. Santrach, and Allan S. Jaffe

Aspirin Responsiveness in Healthy Volunteers Measured with Multiple Assay Platforms
Clin Chem 2008 54: 1060-1065. Published online April 17, 2008; 10.1373/clinchem.2007.101014 [Abstract] [Full Text] [PDF]  

Proteomics and Protein Markers:

Dominique de Seny, Marianne Fillet, Clio Ribbens, Raphaël Marée, Marie-Alice Meuwis, Laurence Lutteri, Jean-Paul Chapelle, Louis Wehenkel, Edouard Louis, Marie-Paule Merville, and Michel Malaise

Monomeric Calgranulins Measured by SELDI-TOF Mass Spectrometry and Calprotectin Measured by ELISA as Biomarkers in Arthritis
Clin Chem 2008 54: 1066-1075. Published online April 24, 2008; 10.1373/clinchem.2007.099549 [Abstract] [Full Text] [PDF] Supplemental Data  

Brief Communications:

Jessie Shih, Saul A. Datwyler, Stephen C. Hsu, Matthew S. Matias, David P. Pacenti, Christian Lueders, Christian Mueller, Oliver Danne, and Martin Möckel

Effect of Collection Tube Type and Preanalytical Handling on Myeloperoxidase Concentrations
Clin Chem 2008 54: 1076-1079. [Abstract] [Full Text] [PDF] Supplemental Data  

Stephanie H. I. Yeung, Igor L. Medintz, Susan A. Greenspoon, and Richard A. Mathies

Rapid Determination of Monozygous Twinning with a Microfabricated Capillary Array Electrophoresis Genetic-Analysis Device
Clin Chem 2008 54: 1080-1084. [Abstract] [Full Text] [PDF] Supplemental Data  

Citation Classics in Clinical Chemistry:

Per Magne Ueland

Importance of Chemical Reduction in Plasma and Serum Homocysteine Analysis
Clin Chem 2008 54: 1085-1086. [Extract] [Full Text] [PDF]  

Letters to the Editor:

Martin Lenicek, Miroslava Juklova, Jaroslav Zelenka, Jan Kovar, Milan Lukas, Martin Bortlik, and Libor Vitek

Improved HPLC Analysis of Serum 7-Hydroxycholest-4-en-3-one, a Marker of Bile Acid Malabsorption
Clin Chem 2008 54: 1087-1088. [Extract] [Full Text] [PDF]  

Megan E. Sullivan, Anna Carolan, James T. Perkins, and Irene J. Check

Unexpected Hemoglobin A Results after an Erythrocyte Exchange: Importance of Specimen Mixing
Clin Chem 2008 54: 1088-1090. [Extract] [Full Text] [PDF]  

Anders Helander and Gunnar Nordin

Insufficient Standardization of a Direct Carbohydrate-Deficient Transferrin Immunoassay
Clin Chem 2008 54: 1090-1092. [Extract] [Full Text] [PDF]  

Adonios Zanglis, Demetrios Andreopoulos, and Nikolaos Baziotis

Influence of L-Thyroxine Therapy on Parathyroid Hormone Concentrations
Clin Chem 2008 54: 1092-1093. [Extract] [Full Text] [PDF]  

Giuseppe Lippi, Federico Schena, Martina Montagnana, Gian Luca Salvagno, Giuseppe Banfi, and Gian Cesare Guidi

Acute Variation of Osteocalcin and Parathyroid Hormone in Athletes after Running a Half-Marathon
Clin Chem 2008 54: 1093-1095. [Extract] [Full Text] [PDF]  

Mikiko Soejima and Yoshiro Koda

Rapid Real-Time PCR Detection of HP^del Directly from Diluted Blood Samples
Clin Chem 2008 54: 1095-1096. [Extract] [Full Text] [PDF]  

Book, Software, and Website Reviews:

Erasmus Schneider

Fundamentals of Molecular Diagnostics. David E. Bruns, Edward R. Ashwood, and Carl A. Burtis, editors. St. Louis, MO: Saunders/Elsevier, 2007, 288 pp, $69.95 (hardcover). ISBN-13: 978-1-4160-3737-8.
Clin Chem 2008 54: 1097. [Extract] [Full Text] [PDF]  

The Clinical Chemist:

Implementation of Standardization of Hemoglobin A_1c Measurement: Condensed Summary of the Meeting with Manufacturers Held in Milan, Italy, December 12, 2007
Clin Chem 2008 54: 1098. [Extract] [Full Text] [PDF]  

Increased Reporting of Estimated Glomerular Filtration Rate and Call for Improved Creatinine Traceability
Clin Chem 2008 54: 1098-1099. [Extract] [Full Text] [PDF]  

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