Special Reports:

Catharine M. Sturgeon, Barry R. Hoffman, Daniel W. Chan, Soo-Ling Ch'ng, Elizabeth Hammond, Daniel F. Hayes, Lance A. Liotta, Emmanuel F. Petricoin, Manfred Schmitt, O. John Semmes, Györg Söletormos, Elena van der Merwe, and Eleftherios P. Diamandis

National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines for Use of Tumor Markers in Clinical Practice: Quality Requirements
Clin Chem 2008 54: 1-10. Published online July 7, 2008; 10.1373/clinchem.2007.094144 [Abstract] [Full Text] [PDF] Supplemental Data  

Editorials:

Sterling T. Bennett

There’s Nothing to Winning, Really
Clin Chem 2008 54: 1265-1267. [Extract] [Full Text] [PDF]  

Endocrinology and Metabolism:

Tuan V. Nguyen, Anne E. Nelson, Christopher J. Howe, Markus J. Seibel, Robert C. Baxter, David J. Handelsman, Ray Kazlauskas, and Ken K. Ho

Within-Subject Variability and Analytic Imprecision of Insulinlike Growth Factor Axis and Collagen Markers: Implications for Clinical Diagnosis and Doping Tests
Clin Chem 2008 54: 1268-1276. Published online June 20, 2008; 10.1373/clinchem.2008.105726 [Abstract] [Full Text] [PDF] Supplemental Data  

Randie R. Little, Curt L. Rohlfing, Steve Hanson, Shawn Connolly, Trefor Higgins, Cas W. Weykamp, Mario D'Costa, Veronica Luzzi, William E. Owen, and William L. Roberts

Effects of Hemoglobin (Hb) E and HbD Traits on Measurements of Glycated Hb (HbA_1c) by 23 Methods
Clin Chem 2008 54: 1277-1282. Published online June 12, 2008; 10.1373/clinchem.2008.103580 [Abstract] [Full Text] [PDF] Supplemental Data  

Sean Mark, Katherine Gray-Donald, Edgard E. Delvin, Jennifer O'Loughlin, Gilles Paradis, Emile Levy, and Marie Lambert

Low Vitamin D Status in a Representative Sample of Youth From Québec, Canada
Clin Chem 2008 54: 1283-1289. Published online June 12, 2008; 10.1373/clinchem.2008.104158 [Abstract] [Full Text] [PDF]  

Linda M. Thienpont, Katleen Van Uytfanghe, Stuart Blincko, Carol S. Ramsay, Hui Xie, Robert C. Doss, Brian G. Keevil, Laura J. Owen, Alan L. Rockwood, Mark M. Kushnir, Kelly Y. Chun, Donald W. Chandler, Helen P. Field, and Patrick M. Sluss

State-of-the-Art of Serum Testosterone Measurement by Isotope Dilution–Liquid Chromatography– Tandem Mass Spectrometry
Clin Chem 2008 54: 1290-1297. Published online June 12, 2008; 10.1373/clinchem.2008.105841 [Abstract] [Full Text] [PDF] Supplemental Data  

Michael J. Murphy, Jo Hosking, Brad S. Metcalf, Linda D. Voss, Alison N. Jeffery, Naveed Sattar, Roger Williams, Jinny Jeffery, and Terence J. Wilkin

Distribution of Adiponectin, Leptin, and Metabolic Correlates of Insulin Resistance: A Longitudinal Study in British Children; 1: Prepuberty (EarlyBird 15)
Clin Chem 2008 54: 1298-1306. Published online June 6, 2008; 10.1373/clinchem.2008.103499 [Abstract] [Full Text] [PDF]  

Lipids, Lipoproteins, and Cardiovascular Risk Factors:

Michael P. Caulfield, Shuguang Li, Gloria Lee, Patricia J. Blanche, Wael A. Salameh, W. Henry Benner, Richard E. Reitz, and Ronald M. Krauss

Direct Determination of Lipoprotein Particle Sizes and Concentrations by Ion Mobility Analysis
Clin Chem 2008 54: 1307-1316. Published online May 29, 2008; 10.1373/clinchem.2007.100586 [Abstract] [Full Text] [PDF] Supplemental Data  

William J. Griffiths, Yuqin Wang, Kersti Karu, Emmanuel Samuel, Shane McDonnell, Martin Hornshaw, and Cedric Shackleton

Potential of Sterol Analysis by Liquid Chromatography–Tandem Mass Spectrometry for the Prenatal Diagnosis of Smith-Lemli-Opitz Syndrome
Clin Chem 2008 54: 1317-1324. Published online June 12, 2008; 10.1373/clinchem.2007.100644 [Abstract] [Full Text] [PDF] Supplemental Data  

Peter G. Scheffer, Tom Teerlink, Jacqueline M. Dekker, Griët Bos, Giel Nijpels, Michaela Diamant, Piet J. Kostense, Coen D. A. Stehouwer, and Robert J. Heine

Increased Plasma Apolipoprotein C-III Concentration Independently Predicts Cardiovascular Mortality: The Hoorn Study
Clin Chem 2008 54: 1325-1330. Published online June 12, 2008; 10.1373/clinchem.2008.103234 [Abstract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Michele Zorzetto, Erich Russi, Oliver Senn, Medea Imboden, Ilaria Ferrarotti, Carmine Tinelli, Ilaria Campo, Stefania Ottaviani, Roberta Scabini, Arnold von Eckardstein, Wolfgang Berger, Otto Brändli, Thierry Rochat, Maurizio Luisetti, Nicole Probst-Hensch the SAPALDIA Team

SERPINA1 Gene Variants in Individuals from the General Population with Reduced ₁-Antitrypsin Concentrations
Clin Chem 2008 54: 1331-1338. Published online May 29, 2008; 10.1373/clinchem.2007.102798 [Abstract] [Full Text] [PDF] Supplement Data  

Proteomics and Protein Markers:

Orlando M. Gutiérrez, Hector Tamez, Ishir Bhan, James Zazra, Marcello Tonelli, Myles Wolf, James L. Januzzi, Yuchiao Chang, and Ravi Thadhani

N-terminal Pro-B–Type Natriuretic Peptide (NT-proBNP) Concentrations in Hemodialysis Patients: Prognostic Value of Baseline and Follow-up Measurements
Clin Chem 2008 54: 1339-1348. Published online June 6, 2008; 10.1373/clinchem.2007.101691 [Abstract] [Full Text] [PDF] Supplemental Data  

General Clinical Chemistry:

Giampaolo Cattozzo, Elena Guerra, Ferruccio Ceriotti, Carlo Franzini on behalf of the Enzyme Working Group of the Italian Society of Clinical Biochemistry and Clinical Molecular Biology (SIBioC)

Commutable Calibrator with Value Assigned by the IFCC Reference Procedure to Harmonize Serum Lactate Dehydrogenase Activity Results Measured by 2 Different Methods
Clin Chem 2008 54: 1349-1355. Published online June 6, 2008; 10.1373/clinchem.2007.100081 [Abstract] [Full Text] [PDF]  

Chloe M. Mak, Ching-Wan Lam, and Sidney Tam

Diagnostic Accuracy of Serum Ceruloplasmin in Wilson Disease: Determination of Sensitivity and Specificity by ROC Curve Analysis among ATP7B-Genotyped Subjects
Clin Chem 2008 54: 1356-1362. Published online June 12, 2008; 10.1373/clinchem.2008.103432 [Abstract] [Full Text] [PDF]  

Diane J. Catellier, Nena Aleksic, Aaron R. Folsom, and Eric Boerwinkle

Atherosclerosis Risk in Communities (ARIC) Carotid MRI Flow Cytometry Study of Monocyte and Platelet Markers: Intraindividual Variability and Reliability
Clin Chem 2008 54: 1363-1371. Published online May 29, 2008; 10.1373/clinchem.2007.102202 [Abstract] [Full Text] [PDF]  

Informatics and Statistics:

Jerome Lambert, Philippe Halfon, Guillaume Penaranda, Pierre Bedossa, Patrice Cacoub, and Fabrice Carrat

How to Measure the Diagnostic Accuracy of Noninvasive Liver Fibrosis Indices: The Area Under the ROC Curve Revisited
Clin Chem 2008 54: 1372-1378. Published online June 6, 2008; 10.1373/clinchem.2007.097923 [Abstract] [Full Text] [PDF] Supplemental Data  

Andrea Geistanger, Sabine Arends, Christoph Berding, Tadao Hoshino, Jan-Olof Jeppsson, Randie Little, Carla Siebelder, Cas Weykamp on behalf of the IFCC Working Group on Standardization of Hemoglobin A_1c

Statistical Methods for Monitoring the Relationship between the IFCC Reference Measurement Procedure for Hemoglobin A_1c and the Designated Comparison Methods in the United States, Japan, and Sweden
Clin Chem 2008 54: 1379-1385. Published online June 6, 2008; 10.1373/clinchem.2008.103556 [Abstract] [Full Text] [PDF] Supplemental Data  

Brief Communications:

Sean O'Halloran and Kenneth F. Ilett

Evaluation of a Deuterium-Labeled Internal Standard for the Measurement of Sirolimus by High-Throughput HPLC Electrospray Ionization Tandem Mass Spectrometry
Clin Chem 2008 54: 1386-1389. [Abstract] [Full Text] [PDF]  

José A. G. Agúndez, Klaus Golka, Carmen Martínez, Silvia Selinski, Meinolf Blaszkewicz, and Elena García-Martín

Unraveling Ambiguous NAT2 Genotyping Data
Clin Chem 2008 54: 1390-1394. [Abstract] [Full Text] [PDF] Supplemental Data  

Clinical Case Study:

Marion L. Snyder and Corinne R. Fantz

Cirrhosis Originally Diagnosed as Nonalcoholic Steatohepatitis
Clin Chem 2008 54: 1395-1398. [Extract] [Full Text] [PDF]  

Morten Dahl

Commentary
Clin Chem 2008 54: 1398-1399. [Extract] [Full Text] [PDF]  

Melissa R. Snyder and W. Edward Highsmith, Jr

Commentary
Clin Chem 2008 54: 1399. [Extract] [Full Text] [PDF]  

Citation Classic:

Frej Fyhrquist and Outi Saijonmaa

Plasma Renin Activity: An Assay with Ongoing Clinical Relevance
Clin Chem 2008 54: 1400. [Extract] [Full Text] [PDF]  

Letters to the Editor:

Tanya Sandrock, Alan Terry, Jeff C. Martin, Evrim Erdogan, and Wayne A. Meikle

Detection of Thyroid-Stimulating Immunoglobulins by Use of Enzyme-Fragment Complementation
Clin Chem 2008 54: 1401-1402. [Extract] [Full Text] [PDF]  

Tsunenobu Tamura and Joseph E. Baggott

In Vitro Formation of Homocysteine in Whole Blood in the Presence of Anticoagulants
Clin Chem 2008 54: 1402-1403. [Extract] [Full Text] [PDF]  

Uwe Pöge, Thomas Gerhardt, and Rainer P. Woitas

Estimation of Glomerular Filtration Rate by Use of Beta-Trace Protein
Clin Chem 2008 54: 1403-1405. [Extract] [Full Text] [PDF]  

Karl Winkler, Michael M. Hoffmann, Ursula Seelhorst, Britta Wellnitz, Bernhard O. Boehm, Bernhard R. Winkelmann, Winfried März, and Hubert Scharnagl

Apolipoprotein A-II Is a Negative Risk Indicator for Cardiovascular and Total Mortality: Findings from the Ludwigshafen Risk and Cardiovascular Health Study
Clin Chem 2008 54: 1405-1406. [Extract] [Full Text] [PDF]  

Michael Vogeser

Instrument-Specific Matrix Effects of Calibration Materials in the LC-MS/MS Analysis of Tacrolimus
Clin Chem 2008 54: 1406-1408. [Extract] [Full Text] [PDF]  

Angela M. Ferguson, Bradley Ford, and Ann M. Gronowski

Method Validation for Cerebral Spinal Fluid Human Chorionic Gonadotropin Measurement with the Advia Centaur®
Clin Chem 2008 54: 1408-1409. [Extract] [Full Text] [PDF]  

Hershel Raff

Immulite vs Scantibodies IRMA Plasma ACTH Assay
Clin Chem 2008 54: 1409-1410. [Extract] [Full Text] [PDF]  

Book, Software and Website Reviews:

Erik Magid

Evidence-Based Laboratory Medicine: Principles, Practice, and Outcomes, 2nd ed. Christopher P. Price and Robert H. Christenson. Washington, DC: AACC Press, 2007, 545 pp, $91.00 ($73.00 AACC members). ISBN 978-1-59425-071-2.
Clin Chem 2008 54: 1411. [Extract] [Full Text] [PDF]  

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