Introduction:

Y. M. Dennis Lo and Carl T. Wittwer

Molecular Diagnostics: At the Cutting Edge of Translational Research
Clin Chem 2009 55: 601. [Extract] [Full Text] [PDF]  

Editorials:

Samuil R. Umansky

From Transrenal DNA to Stem Cell Differentiation: An Unexpected Twist
Clin Chem 2009 55: 602-604. Published online February 6, 2009; 10.1373/clinchem.2008.119552 [Extract] [Full Text] [PDF]  

Margit Bauer and Barbara Pertl

On Targeting Cell-Free DNA in Urine: A Protocol for Optimized DNA Analysis
Clin Chem 2009 55: 605-606. Published online February 20, 2009; 10.1373/clinchem.2008.121855 [Extract] [Full Text] [PDF]  

Y.M. Dennis Lo and Rossa W.K. Chiu

Next-Generation Sequencing of Plasma/Serum DNA: An Emerging Research and Molecular Diagnostic Tool
Clin Chem 2009 55: 607-608. Published online February 20, 2009; 10.1373/clinchem.2009.123661 [Extract] [Full Text] [PDF]  

Perspective:

Daniel C. Leslie and James P. Landers

A New Tool for Oligonulceotide Import into Cells
Clin Chem 2009 55: 609-610. Published online February 20, 2009; 10.1373/clinchem.2008.113019 [Extract] [Full Text] [PDF]  

Special Reports:

Stephen A. Bustin, Vladimir Benes, Jeremy A. Garson, Jan Hellemans, Jim Huggett, Mikael Kubista, Reinhold Mueller, Tania Nolan, Michael W. Pfaffl, Gregory L. Shipley, Jo Vandesompele, and Carl T. Wittwer

The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments
Clin Chem 2009 55: 611-622. Published online February 26, 2009; 10.1373/clinchem.2008.112797 [Abstract] [Full Text] [PDF]  

Mini-Reviews:

Claudine L. Bartels and Gregory J. Tsongalis

MicroRNAs: Novel Biomarkers for Human Cancer
Clin Chem 2009 55: 623-631. Published online February 26, 2009; 10.1373/clinchem.2008.112805 [Abstract] [Full Text] [PDF]  

Coren A. Milbury, Jin Li, and G. Mike Makrigiorgos

PCR-Based Methods for the Enrichment of Minority Alleles and Mutations
Clin Chem 2009 55: 632-640. Published online February 6, 2009; 10.1373/clinchem.2008.113035 [Abstract] [Full Text] [PDF]  

Reviews:

Karl V. Voelkerding, Shale A. Dames, and Jacob D. Durtschi

Next-Generation Sequencing: From Basic Research to Diagnostics
Clin Chem 2009 55: 641-658. Published online February 26, 2009; 10.1373/clinchem.2008.112789 [Abstract] [Full Text] [PDF] Supplemental Data  

Yiping Shen and Bai-Lin Wu

Microarray-Based Genomic DNA Profiling Technologies in Clinical Molecular Diagnostics
Clin Chem 2009 55: 659-669. Published online February 20, 2009; 10.1373/clinchem.2008.112821 [Abstract] [Full Text] [PDF]  

Larry J. Kricka and Paolo Fortina

Analytical Ancestry: "Firsts" in Fluorescent Labeling of Nucleosides, Nucleotides, and Nucleic Acids
Clin Chem 2009 55: 670-683. Published online February 20, 2009; 10.1373/clinchem.2008.116152 [Abstract] [Full Text] [PDF]  

Jonathan B. Overdevest, Dan Theodorescu, and Jae K. Lee

Utilizing the Molecular Gateway: The Path to Personalized Cancer Management
Clin Chem 2009 55: 684-697. Published online February 26, 2009; 10.1373/clinchem.2008.118554 [Abstract] [Full Text] [PDF]  

Karen M. K. de Vooght, Richard van Wijk, and Wouter W. van Solinge

Management of Gene Promoter Mutations in Molecular Diagnostics
Clin Chem 2009 55: 698-708. Published online February 26, 2009; 10.1373/clinchem.2008.120931 [Abstract] [Full Text] [PDF]  

Point/Counterpoint:

Mia Wadelius

Point: Use of Pharmacogenetics in Guiding Treatment with Warfarin
Clin Chem 2009 55: 709-711. Published online January 30, 2009; 10.1373/clinchem.2008.115964 [Extract] [Full Text] [PDF]  

Charles S. Eby

Counterpoint: Pharmacogenetic-Based Initial Dosing of Warfarin: Not Ready for Prime Time
Clin Chem 2009 55: 712-714. Published online February 20, 2009; 10.1373/clinchem.2008.115972 [Extract] [Full Text] [PDF]  

Molecular Diagnostics and Genetics:

Emily C.W. Hung, Tristan K.F. Shing, Stephen S.C. Chim, Philip C. Yeung, Rebecca W.Y. Chan, Ki W. Chik, Vincent Lee, Nancy B.Y. Tsui, Chi-Kong Li, Cesar S.C. Wong, Rossa W.K. Chiu, and Y.M. Dennis Lo

Presence of Donor-Derived DNA and Cells in the Urine of Sex-Mismatched Hematopoietic Stem Cell Transplant Recipients: Implication for the Transrenal Hypothesis
Clin Chem 2009 55: 715-722. Published online October 30, 2008; 10.1373/clinchem.2008.113530 [Abstract] [Full Text] [PDF]  

Eugene M. Shekhtman, Kalpana Anne, Hovsep S. Melkonyan, David J. Robbins, Steven L. Warsof, and Samuil R. Umansky

Optimization of Transrenal DNA Analysis: Detection of Fetal DNA in Maternal Urine
Clin Chem 2009 55: 723-729. Published online January 30, 2009; 10.1373/clinchem.2008.113050 [Abstract] [Full Text] [PDF]  

Julia Beck, Howard B. Urnovitz, Joachim Riggert, Mario Clerici, and Ekkehard Schütz

Profile of the Circulating DNA in Apparently Healthy Individuals
Clin Chem 2009 55: 730-738. Published online January 30, 2009; 10.1373/clinchem.2008.113597 [Abstract] [Full Text] [PDF] Supplemental Data  

János Márki-Zay, Christoph L. Klein, David Gancberg, Heinz G. Schimmel, and László Dux

European External Quality Control Study on the Competence of Laboratories to Recognize Rare Sequence Variants Resulting in Unusual Genotyping Results
Clin Chem 2009 55: 739-747. Published online February 20, 2009; 10.1373/clinchem.2008.112102 [Abstract] [Full Text] [PDF]  

Jin Li, Lilin Wang, Pasi A. Jänne, and G. Mike Makrigiorgos

Coamplification at Lower Denaturation Temperature-PCR Increases Mutation-Detection Selectivity of TaqMan-Based Real-Time PCR
Clin Chem 2009 55: 748-756. Published online February 20, 2009; 10.1373/clinchem.2008.113381 [Abstract] [Full Text] [PDF] Supplemental Data  

Minoru Kitago, Kazuo Koyanagi, Takeshi Nakamura, Yasufumi Goto, Mark Faries, Steven J. O'Day, Donald L. Morton, Soldano Ferrone, and Dave S.B. Hoon

mRNA Expression and BRAF Mutation in Circulating Melanoma Cells Isolated from Peripheral Blood with High Molecular Weight Melanoma-Associated Antigen-Specific Monoclonal Antibody Beads
Clin Chem 2009 55: 757-764. Published online February 20, 2009; 10.1373/clinchem.2008.116467 [Abstract] [Full Text] [PDF]  

Pauliina Helo, Angel M. Cronin, Daniel C. Danila, Sven Wenske, Rita Gonzalez-Espinoza, Aseem Anand, Michael Koscuiszka, Riina-Minna Väänänen, Kim Pettersson, Felix K.-H. Chun, Thomas Steuber, Hartwig Huland, Bertrand D. Guillonneau, James A. Eastham, Peter T. Scardino, Martin Fleisher, Howard I. Scher, and Hans Lilja

Circulating Prostate Tumor Cells Detected by Reverse Transcription-PCR in Men with Localized or Castration-Refractory Prostate Cancer: Concordance with CellSearch Assay and Association with Bone Metastases and with Survival
Clin Chem 2009 55: 765-773. Published online February 20, 2009; 10.1373/clinchem.2008.117952 [Abstract] [Full Text] [PDF] Supplemental Data  

Harris P.Y. Fan, Chen Di Liao, Brenda Yan Fu, Linda C.W. Lam, and Nelson L.S. Tang

Interindividual and Interethnic Variation in Genomewide Gene Expression: Insights into the Biological Variation of Gene Expression and Clinical Implications
Clin Chem 2009 55: 774-785. Published online February 20, 2009; 10.1373/clinchem.2008.119107 [Abstract] [Full Text] [PDF] Supplemental Data  

Blanca Lumbreras, Lucy A. Parker, Miquel Porta, Marina Pollán, John P.A. Ioannidis, and Ildefonso Hernández-Aguado

Overinterpretation of Clinical Applicability in Molecular Diagnostic Research
Clin Chem 2009 55: 786-794. Published online February 20, 2009; 10.1373/clinchem.2008.121517 [Abstract] [Full Text] [PDF] Supplemental Data  

Evidence-based Medicine and Test Utilization:

Aasne K. Aarsand, Helge Boman, and Sverre Sandberg

Familial and Sporadic Porphyria Cutanea Tarda: Characterization and Diagnostic Strategies
Clin Chem 2009 55: 795-803. Published online February 20, 2009; 10.1373/clinchem.2008.117432 [Abstract] [Full Text] [PDF]  

Point-of-Care Testing:

Tohru Aomori, Koujirou Yamamoto, Atsuko Oguchi-Katayama, Yuki Kawai, Takefumi Ishidao, Yasumasa Mitani, Yasushi Kogo, Alexander Lezhava, Yukiyoshi Fujita, Kyoko Obayashi, Katsunori Nakamura, Hugo Kohnke, Mia Wadelius, Lena Ekström, Cristine Skogastierna, Anders Rane, Masahiko Kurabayashi, Masami Murakami, Paul E. Cizdziel, Yoshihide Hayashizaki, and Ryuya Horiuchi

Rapid Single-Nucleotide Polymorphism Detection of Cytochrome P450 (CYP2C9) and Vitamin K Epoxide Reductase (VKORC1) Genes for the Warfarin Dose Adjustment by the SMart-Amplification Process Version 2
Clin Chem 2009 55: 804-812. Published online January 30, 2009; 10.1373/clinchem.2008.115295 [Abstract] [Full Text] [PDF]  

Infectious Disease:

Zhiwen Tang, Parag Parekh, Pete Turner, Richard W. Moyer, and Weihong Tan

Generating Aptamers for Recognition of Virus-Infected Cells
Clin Chem 2009 55: 813-822. Published online February 26, 2009; 10.1373/clinchem.2008.113514 [Abstract] [Full Text] [PDF] Supplemental Data  

Brief Communication:

Alex J. Rai, Nitin Udar, Rana Saad, and Martin Fleisher

A Multiplex Assay for Detecting Genetic Variations in CYP2C9, VKORC1, and GGCX Involved in Warfarin Metabolism
Clin Chem 2009 55: 823-826. Published online February 20, 2009; 10.1373/clinchem.2008.118497 [Abstract] [Full Text] [PDF] Supplemental Data  

Clinical Case Study:

David T. Miller, Yiping Shen, David J. Harris, Bai-Lin Wu, and Magdi M. Sobeih

Genetic Testing for Developmental Delay: Keep Searching for an Answer
Clin Chem 2009 55: 827-830. [Extract] [Full Text] [PDF]  

Sau Wai Cheung

Commentary
Clin Chem 2009 55: 830-831. [Extract] [Full Text] [PDF]  

Nelson L.S. Tang

Commentary
Clin Chem 2009 55: 831-832. [Extract] [Full Text] [PDF]  

Citation Classics:

P. Mickey Williams

The Beginnings of Real-Time PCR
Clin Chem 2009 55: 833-834. Published online March 4, 2009; 10.1373/clinchem.2008.122226 [Extract] [Full Text] [PDF]  

Interview:

Misia Landau

A Conversation with Elizabeth Blackburn
Clin Chem 2009 55: 835-841. Published online February 20, 2009; 10.1373/clinchem.2008.119578 [Extract] [Full Text] [PDF]  

Letter to the Editor:

Malin I. L. Ivarsson, Joakim Dillner, and Joyce Carlson

Validity of Maternal Genotypes in DNA from Archival Pregnancy Serum Samples
Clin Chem 2009 55: 842-843. [Extract] [Full Text] [PDF]  

Clinical Chemist:

Lily Robinson and the Mount Vernon Affair: Recollections
Clin Chem 2009 55: 844. [Extract] [Full Text] [PDF]  

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