Editorials:

Børge G. Nordestgaard and Marianne Benn

Fasting and Nonfasting LDL Cholesterol: To Measure or Calculate?
Clin Chem 2009 55: 845-847. Published online March 12, 2009; 10.1373/clinchem.2008.123083 [Extract] [Full Text] [PDF]  

George G. Klee

Assay Configuration and Analytic Specificity May Have Major Effects on Prediction of Clinical Outcomes— Implications for Reference Standards
Clin Chem 2009 55: 848-849. Published online March 19, 2009; 10.1373/clinchem.2009.124172 [Extract] [Full Text] [PDF]  

David E. Bruns and William C. Knowler

Stabilization of Glucose in Blood Samples: Why It Matters
Clin Chem 2009 55: 850-852. Published online March 12, 2009; 10.1373/clinchem.2009.126037 [Extract] [Full Text] [PDF]  

Perspective:

Andrea Rita Horvath

Grading Quality of Evidence and Strength of Recommendations for Diagnostic Tests and Strategies
Clin Chem 2009 55: 853-855. Published online March 19, 2009; 10.1373/clinchem.2008.117614 [Extract] [Full Text] [PDF]  

Reviews:

Joseph F. Petrosino, Sarah Highlander, Ruth Ann Luna, Richard A. Gibbs, and James Versalovic

Metagenomic Pyrosequencing and Microbial Identification
Clin Chem 2009 55: 856-866. Published online March 5, 2009; 10.1373/clinchem.2008.107565 [Abstract] [Full Text] [PDF]  

Duncan J. Campbell, Juerg Nussberger, Michael Stowasser, A.H. Jan Danser, Alberto Morganti, Erik Frandsen, and Joël Ménard

Activity Assays and Immunoassays for Plasma Renin and Prorenin: Information Provided and Precautions Necessary for Accurate Measurement
Clin Chem 2009 55: 867-877. Published online March 5, 2009; 10.1373/clinchem.2008.118000 [Abstract] [Full Text] [PDF] Supplemental Data  

Cristina Vassalle and Maria Grazia Andreassi

Genetic Polymorphisms of the Natriuretic Peptide System in the Pathogenesis of Cardiovascular Disease: What Lies on the Horizon?
Clin Chem 2009 55: 878-887. Published online March 26, 2009; 10.1373/clinchem.2008.120832 [Abstract] [Full Text] [PDF]  

Lipids, Lipoproteins, and Cardiovascular Risk Factors:

Samia Mora, Nader Rifai, Julie E. Buring, and Paul M Ridker

Comparison of LDL Cholesterol Concentrations by Friedewald Calculation and Direct Measurement in Relation to Cardiovascular Events in 27 331 Women
Clin Chem 2009 55: 888-894. [Abstract] [Full Text] [PDF]  

Cancer Diagnostics:

Pieter H. Anborgh, Sylvia M. Wilson, Alan B. Tuck, Eric Winquist, Nancy Schmidt, Russell Hart, Shigeyuki Kon, Masahiro Maeda, Toshimitsu Uede, Larry W. Stitt, and Ann F. Chambers

New Dual Monoclonal ELISA for Measuring Plasma Osteopontin as a Biomarker Associated with Survival in Prostate Cancer: Clinical Validation and Comparison of Multiple ELISAs
Clin Chem 2009 55: 895-903. Published online March 26, 2009; 10.1373/clinchem.2008.117465 [Abstract] [Full Text] [PDF] Supplemental Data  

Dimitrios Korbakis, Alkiviades K. Gregorakis, and Andreas Scorilas

Quantitative Analysis of Human Kallikrein 5 (KLK5) Expression in Prostate Needle Biopsies: An Independent Cancer Biomarker
Clin Chem 2009 55: 904-913. Published online March 19, 2009; 10.1373/clinchem.2008.103788 [Abstract] [Full Text] [PDF]  

Mirco Schapher, Olaf Wendler, Michael Gröschl, Renate Schäfer, Heinrich Iro, and Johannes Zenk

Salivary Leptin as a Candidate Diagnostic Marker in Salivary Gland Tumors
Clin Chem 2009 55: 914-922. Published online March 19, 2009; 10.1373/clinchem.2008.116939 [Abstract] [Full Text] [PDF] Supplemental Data  

Proteomics and Protein Markers:

Lutz Frankenstein, Andrew Remppis, Joerdis Frankenstein, Georg Hess, Dietmar Zdunek, Karen Slottje, Hugo A. Katus, and Christian Zugck

Variability of N-Terminal Probrain Natriuretic Peptide in Stable Chronic Heart Failure and Its Relation to Changes in Clinical Variables
Clin Chem 2009 55: 923-929. Published online March 19, 2009; 10.1373/clinchem.2008.112052 [Abstract] [Full Text] [PDF]  

Fred S. Apple, Lesly A. Pearce, Stephen W. Smith, Jason M. Kaczmarek, and MaryAnn M. Murakami

Role of Monitoring Changes in Sensitive Cardiac Troponin I Assay Results for Early Diagnosis of Myocardial Infarction and Prediction of Risk of Adverse Events
Clin Chem 2009 55: 930-937. Published online March 19, 2009; 10.1373/clinchem.2008.114728 [Abstract] [Full Text] [PDF]  

Kim Pettersson, Susann Eriksson, Saara Wittfooth, Emilia Engström, Markku Nieminen, and Juha Sinisalo

Autoantibodies to Cardiac Troponin Associate with Higher Initial Concentrations and Longer Release of Troponin I in Acute Coronary Syndrome Patients
Clin Chem 2009 55: 938-945. Published online March 5, 2009; 10.1373/clinchem.2008.115469 [Abstract] [Full Text] [PDF]  

Karolien Van den Bergh, Herbert Hooijkaas, Daniel Blockmans, René Westhovens, Katrijn Op De Beéck, Patrick Verschueren, Diana Dufour, Joop P. van de Merwe, Monika Fijak, Jörg Klug, Georges Michiels, Benoit Devogelaere, Humbert De Smedt, Rita Derua, Etienne Waelkens, Norbert Blanckaert, and Xavier Bossuyt

Heterogeneous Nuclear Ribonucleoprotein H1, a Novel Nuclear Autoantigen
Clin Chem 2009 55: 946-954. Published online March 5, 2009; 10.1373/clinchem.2008.115626 [Abstract] [Full Text] [PDF]  

Automation and Analytical Techniques:

Er-Qun Song, Zhi-Ling Zhang, Qing-Ying Luo, Wen Lu, Yun-Bo Shi, and Dai-Wen Pang

Tumor Cell Targeting Using Folate-Conjugated Fluorescent Quantum Dots and Receptor-Mediated Endocytosis
Clin Chem 2009 55: 955-963. Published online March 12, 2009; 10.1373/clinchem.2008.113423 [Abstract] [Full Text] [PDF]  

Yong Huang, Tai-Hong Wang, Jian-Hui Jiang, Guo-Li Shen, and Ru-Qin Yu

Prostate Specific Antigen Detection Using Microgapped Electrode Array Immunosensor with Enzymatic Silver Deposition
Clin Chem 2009 55: 964-971. Published online March 5, 2009; 10.1373/clinchem.2008.116582 [Abstract] [Full Text] [PDF] Supplemental Data  

Endocrinology and Metabolism:

Channa N. Jayasena, Kunal A. Gadhvi, Bhavini Gohel, Niamh M. Martin, Nigel Mendoza, Karim Meeran, and Waljit S. Dhillo

Day 5 Morning Serum Cortisol Predicts Hypothalamic-Pituitary-Adrenal Function after Transsphenoidal Surgery for Pituitary Tumors
Clin Chem 2009 55: 972-977. Published online March 12, 2009; 10.1373/clinchem.2008.117374 [Abstract] [Full Text] [PDF]  

Clinical Immunology:

Cornelia Dähnrich, Albert Pares, Llorenç Caballeria, Anke Rosemann, Wolfgang Schlumberger, Christian Probst, Maria Mytilinaiou, Dimitrios Bogdanos, Diego Vergani, Winfried Stöcker, and Lars Komorowski

New ELISA for Detecting Primary Biliary Cirrhosis–Specific Antimitochondrial Antibodies
Clin Chem 2009 55: 978-985. Published online March 5, 2009; 10.1373/clinchem.2008.118299 [Abstract] [Full Text] [PDF]  

Drug Monitoring and Toxicology:

Olivier Gensburger, Nicolas Picard, and Pierre Marquet

Effect of Mycophenolate Acyl-Glucuronide on Human Recombinant Type 2 Inosine Monophosphate Dehydrogenase
Clin Chem 2009 55: 986-993. Published online March 19, 2009; 10.1373/clinchem.2008.113936 [Abstract] [Full Text] [PDF]  

Evidence-Based Medicine and Test Utilization:

Kristel J.M. Janssen, Yvonne Vergouwe, A. Rogier T. Donders, Frank E. Harrell, Jr., Qingxia Chen, Diederick E. Grobbee, and Karel G.M. Moons

Dealing with Missing Predictor Values When Applying Clinical Prediction Models
Clin Chem 2009 55: 994-1001. Published online March 12, 2009; 10.1373/clinchem.2008.115345 [Abstract] [Full Text] [PDF] Supplemental Data  

General Clinical Chemistry:

Tore Forsingdal Hardlei and Ebba Nexo

A New Principle for Measurement of Cobalamin and Corrinoids, Used for Studies of Cobalamin Analogs on Serum Haptocorrin
Clin Chem 2009 55: 1002-1010. Published online March 19, 2009; 10.1373/clinchem.2008.114132 [Abstract] [Full Text] [PDF]  

W. Greg Miller, Linda M. Thienpont, Katleen Van Uytfanghe, Penelope M. Clark, Patrik Lindstedt, Göran Nilsson, Michael W. Steffes for the Insulin Standardization Work Group

Toward Standardization of Insulin Immunoassays
Clin Chem 2009 55: 1011-1018. Published online March 26, 2009; 10.1373/clinchem.2008.118380 [Abstract] [Full Text] [PDF] Supplemental Data  

Brief Communications:

Raymond Gambino, Janet Piscitelli, Tomy A. Ackattupathil, Judy L. Theriault, Reynaldo D. Andrin, Michael L. Sanfilippo, and Monina Etienne

Acidification of Blood Is Superior to Sodium Fluoride Alone as an Inhibitor of Glycolysis
Clin Chem 2009 55: 1019-1021. Published online March 12, 2009; 10.1373/clinchem.2008.121707 [Abstract] [Full Text] [PDF]  

Hyun Jeong Kim, Sang Wook Oh, Dong Joon Kim, and Eui Yul Choi

Abundance of Immunologically Active Alanine Aminotransferase in Sera of Liver Cirrhosis and Hepatocellular Carcinoma Patients
Clin Chem 2009 55: 1022-1025. Published online March 5, 2009; 10.1373/clinchem.2008.102996 [Abstract] [Full Text] [PDF] Supplemental Data  

Clinical Case Study:

Jürgen J. Wenzel, Heidi Rossmann, Ulrike Kullmer, Bettina Oberman, Eugen Mengel, Karl J. Lackner, and Johannes Lotz

Chronic Diarrhea in a 5-Year-Old Girl: Pitfall in Routine Laboratory Testing with Potentially Severe Consequences
Clin Chem 2009 55: 1026-1030. [Extract] [Full Text] [PDF]  

Commentaries:

C.M. Frank Kneepkens

Commentary
Clin Chem 2009 55: 1030-1031. [Extract] [Full Text] [PDF]  

David A. Rudnick

Commentary
Clin Chem 2009 55: 1031. [Extract] [Full Text] [PDF]  

Citation Classics:

Juha Risteli and Leila Risteli

Serum-Based Test of the Pathologic Breakdown of Type I Collagen Fibers
Clin Chem 2009 55: 1032-1033. Published online March 12, 2009; 10.1373/clinchem.2008.106674 [Extract] [Full Text] [PDF]  

Letters to the Editor:

Orfeu M. Buxton, Keith Malarick, Wei Wang, and Teresa Seeman

Changes in Dried Blood Spot Hb A_1c with Varied Postcollection Conditions
Clin Chem 2009 55: 1034-1036. Published online March 19, 2009; 10.1373/clinchem.2008.111641 [Extract] [Full Text] [PDF] Supplemental Data  

Ranieri Rossi and Dimitrios Tsikas

S-Nitrosothiols in Blood: Does Photosensitivity Explain a 4-Order-of-Magnitude Concentration Range?
Clin Chem 2009 55: 1036-1038. Published online March 12, 2009; 10.1373/clinchem.2008.114462 [Extract] [Full Text] [PDF]  

Yiduo Wu, Wansik Cha, Fenghua Zhang, and Mark E. Meyerhoff

In Reply
Clin Chem 2009 55: 1038-1040. Published online March 19, 2009; 10.1373/clinchem.2008.122705 [Extract] [Full Text] [PDF]  

Goce Dimeski, Brock Jones, and Jacobus P.J. Ungerer

Interference from Rose Bengal with Total Bilirubin Measurement
Clin Chem 2009 55: 1040-1041. Published online March 5, 2009; 10.1373/clinchem.2008.116731 [Extract] [Full Text] [PDF]  

Hans-Gert Bernstein and Karl-Heinz Braunewell

Some Notes on Visinin-Like Protein 1 and Alzheimer Disease
Clin Chem 2009 55: 1041-1043. Published online March 5, 2009; 10.1373/clinchem.2008.116970 [Extract] [Full Text] [PDF]  

Holger K. de Wolf, Jacqueline Klein Gunnewiek, Yvonne Berk, Jody van den Ouweland, and Menno de Metz

Comparison of a New Procalcitonin Assay from Roche with the Established Method on the Brahms Kryptor
Clin Chem 2009 55: 1043-1044. Published online March 5, 2009; 10.1373/clinchem.2008.117655 [Extract] [Full Text] [PDF]  

David Cartwright, Paula O'Shea, Odelia Rajanayagam, Maura Agostini, Peter Barker, Carla Moran, Enrico Macchia, Aldo Pinchera, Rhys John, Amar Agha, H. Alec Ross, V. Krishna Chatterjee, and David J. Halsall

Familial Dysalbuminemic Hyperthyroxinemia: A Persistent Diagnostic Challenge
Clin Chem 2009 55: 1044-1046. Published online March 12, 2009; 10.1373/clinchem.2008.120303 [Extract] [Full Text] [PDF]  

Clinical Chemist:

Lily Robinson and Death Outside the Box
Clin Chem 2009 55: 1047-1048. [Extract] [Full Text] [PDF]  

Clinical Chemistry to Introduce Three New Educational Features
Clin Chem 2009 55: 1049. [Extract] [Full Text] [PDF]  

Nader Rifai, James Boyd, and Thomas Annesley

Editors’ Note
Clin Chem 2009 55: 1049. [Extract] [Full Text] [PDF]  

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