Preamble:

Glen L. Hortin, Steven A. Carr, and N. Leigh Anderson

Introduction: Advances in Protein Analysis for the Clinical Laboratory
Clin Chem 2010 56: 149-151. Published online November 12, 2009; 10.1373/clinchem.2009.132803 [Extract] [Full Text] [PDF]  

Editorials:

Markus Otto

Dementia Diagnostics 2.0—Transfer from Research Studies into Routine Clinical Practice
Clin Chem 2010 56: 152-153. Published online November 2, 2009; 10.1373/clinchem.2009.136051 [Extract] [Full Text] [PDF]  

Reflection:

Norman G. Anderson

Adventures in Clinical Chemistry and Proteomics: A Personal Account
Clin Chem 2010 56: 154-160. Published online November 5, 2009; 10.1373/clinchem.2009.126680 [Extract] [Full Text] [PDF]  

Perspective:

Andrew N. Hoofnagle

Quantitative Clinical Proteomics by Liquid Chromatography–Tandem Mass Spectrometry: Assessing the Platform
Clin Chem 2010 56: 161-164. Published online December 3, 2009; 10.1373/clinchem.2009.134049 [Extract] [Full Text] [PDF]  

Special Reports:

Fred E. Regnier, Steven J. Skates, Mehdi Mesri, Henry Rodriguez, Zivana Tezak, Marina V. Kondratovich, Michail A. Alterman, Joshua D. Levin, Donna Roscoe, Eugene Reilly, James Callaghan, Kellie Kelm, David Brown, Reena Philip, Steven A. Carr, Daniel C. Liebler, Susan J. Fisher, Paul Tempst, Tara Hiltke, Larry G. Kessler, Christopher R. Kinsinger, David F. Ransohoff, Elizabeth Mansfield, and N. Leigh Anderson

Protein-Based Multiplex Assays: Mock Presubmissions to the US Food and Drug Administration
Clin Chem 2010 56: 165-171. Published online December 10, 2009; 10.1373/clinchem.2009.140087 [Abstract] [Full Text] [PDF] Supplemental Data  

Mini-Reviews:

David F. Ransohoff

Proteomics Research to Discover Markers: What Can We Learn from Netflix®?
Clin Chem 2010 56: 172-176. Published online December 29, 2009; 10.1373/clinchem.2009.126698 [Abstract] [Full Text] [PDF] Supplemental Data  

N. Leigh Anderson

The Clinical Plasma Proteome: A Survey of Clinical Assays for Proteins in Plasma and Serum
Clin Chem 2010 56: 177-185. Published online November 2, 2009; 10.1373/clinchem.2009.126706 [Abstract] [Full Text] [PDF] Supplemental Data  

Allison A. Ellington, Iftikhar J. Kullo, Kent R. Bailey, and George G. Klee

Antibody-Based Protein Multiplex Platforms: Technical and Operational Challenges
Clin Chem 2010 56: 186-193. Published online December 3, 2009; 10.1373/clinchem.2009.127514 [Abstract] [Full Text] [PDF]  

Robert E. Gerszten, Steven A. Carr, and Marc Sabatine

Integration of Proteomic-Based Tools for Improved Biomarkers of Myocardial Injury
Clin Chem 2010 56: 194-201. Published online December 18, 2009; 10.1373/clinchem.2009.127878 [Abstract] [Full Text] [PDF]  

Chad R. Borges, Doug S. Rehder, Jason W. Jarvis, Mathew R. Schaab, Paul E. Oran, and Randall W. Nelson

Full-Length Characterization of Proteins in Human Populations
Clin Chem 2010 56: 202-211. Published online November 19, 2009; 10.1373/clinchem.2009.134858 [Abstract] [Full Text] [PDF] Supplemental Data  

Reviews:

Shalini Makawita and Eleftherios P. Diamandis

The Bottleneck in the Cancer Biomarker Pipeline and Protein Quantification through Mass Spectrometry–Based Approaches: Current Strategies for Candidate Verification
Clin Chem 2010 56: 212-222. Published online December 10, 2009; 10.1373/clinchem.2009.127019 [Abstract] [Full Text] [PDF]  

Penelope M. Drake, Wonryeon Cho, Bensheng Li, Akraporn Prakobphol, Eric Johansen, N. Leigh Anderson, Fred E. Regnier, Bradford W. Gibson, and Susan J. Fisher

Sweetening the Pot: Adding Glycosylation to the Biomarker Discovery Equation
Clin Chem 2010 56: 223-236. Published online December 3, 2009; 10.1373/clinchem.2009.136333 [Abstract] [Full Text] [PDF] Supplemental Data  

Henry Rodriguez, Zivana Tezak, Mehdi Mesri, Steven A. Carr, Daniel C. Liebler, Susan J. Fisher, Paul Tempst, Tara Hiltke, Larry G. Kessler, Christopher R. Kinsinger, Reena Philip, David F. Ransohoff, Steven J. Skates, Fred E. Regnier, N. Leigh Anderson, Elizabeth Mansfield on behalf of the Workshop Participants

Analytical Validation of Protein-Based Multiplex Assays: A Workshop Report by the NCI-FDA Interagency Oncology Task Force on Molecular Diagnostics
Clin Chem 2010 56: 237-243. Published online December 10, 2009; 10.1373/clinchem.2009.136416 [Abstract] [Full Text] [PDF]  

Opinion:

Michael T. Davis, Paul L. Auger, and Scott D. Patterson

Cancer Biomarker Discovery via Low Molecular Weight Serum Profiling—Are We Following Circular Paths?
Clin Chem 2010 56: 244-247. Published online December 3, 2009; 10.1373/clinchem.2009.127951 [Extract] [Full Text] [PDF]  

Proteomics and Protein Markers:

Cees Mulder, Nicolaas A. Verwey, Wiesje M. van der Flier, Femke H. Bouwman, Astrid Kok, Evert J. van Elk, Philip Scheltens, and Marinus A. Blankenstein

Amyloid-β(1–42), Total Tau, and Phosphorylated Tau as Cerebrospinal Fluid Biomarkers for the Diagnosis of Alzheimer Disease
Clin Chem 2010 56: 248-253. Published online October 15, 2009; 10.1373/clinchem.2009.130518 [Abstract] [Full Text] [PDF]  

Evangelos Giannitsis, Kerstin Kurz, Klaus Hallermayer, Jochen Jarausch, Allan S. Jaffe, and Hugo A. Katus

Analytical Validation of a High-Sensitivity Cardiac Troponin T Assay
Clin Chem 2010 56: 254-261. Published online December 3, 2009; 10.1373/clinchem.2009.132654 [Abstract] [Full Text] [PDF] Supplemental Data  

John F. Timms, Rainer Cramer, Stephane Camuzeaux, Ali Tiss, Celia Smith, Brian Burford, Ilia Nouretdinov, Dmitry Devetyarov, Aleksandra Gentry-Maharaj, Jeremy Ford, Zhiyuan Luo, Alex Gammerman, Usha Menon, and Ian Jacobs

Peptides Generated Ex Vivo from Serum Proteins by Tumor-Specific Exopeptidases Are Not Useful Biomarkers in Ovarian Cancer
Clin Chem 2010 56: 262-271. Published online January 21, 2010; 10.1373/clinchem.2009.133363 [Abstract] [Full Text] [PDF] Supplemental Data  

Teresa Peccerella, Nadine Lukan, Ralf Hofheinz, Dirk Schadendorf, Markus Kostrezewa, Michael Neumaier, and Peter Findeisen

Endoprotease Profiling with Double-Tagged Peptide Substrates: A New Diagnostic Approach in Oncology
Clin Chem 2010 56: 272-280. [Abstract] [Full Text] [PDF] Supplemental Data  

Mary F. Lopez, Taha Rezai, David A. Sarracino, Amol Prakash, Bryan Krastins, Michael Athanas, Ravinder J. Singh, David R. Barnidge, Paul Oran, Chad Borges, and Randall W. Nelson

Selected Reaction Monitoring–Mass Spectrometric Immunoassay Responsive to Parathyroid Hormone and Related Variants
Clin Chem 2010 56: 281-290. Published online December 18, 2009; 10.1373/clinchem.2009.137323 [Abstract] [Full Text] [PDF] Supplemental Data  

Susan E. Abbatiello, D. R. Mani, Hasmik Keshishian, and Steven A. Carr

Automated Detection of Inaccurate and Imprecise Transitions in Peptide Quantification by Multiple Reaction Monitoring Mass Spectrometry
Clin Chem 2010 56: 291-305. Published online December 18, 2009; 10.1373/clinchem.2009.138420 [Abstract] [Full Text] [PDF] Supplemental Data  

Endocrinology and Metabolism:

Vivek Kumar, David R. Barnidge, Li-Sheng Chen, Jolaine M. Twentyman, Kendall W. Cradic, Stefan K. Grebe, and Ravinder J. Singh

Quantification of Serum 1–84 Parathyroid Hormone in Patients with Hyperparathyroidism by Immunocapture In Situ Digestion Liquid Chromatography–Tandem Mass Spectrometry
Clin Chem 2010 56: 306-313. Published online December 10, 2009; 10.1373/clinchem.2009.134643 [Abstract] [Full Text] [PDF] Supplemental Data  

Brief Communication:

Qin Fu, Jie Zhu, and Jennifer E. Van Eyk

Comparison of Multiplex Immunoassay Platforms
Clin Chem 2010 56: 314-318. Published online December 18, 2009; 10.1373/clinchem.2009.135087 [Abstract] [Full Text] [PDF] Supplemental Data  

Citation Classic:

Eva Engvall

The ELISA, Enzyme-Linked Immunosorbent Assay
Clin Chem 2010 56: 319-320. Published online October 22, 2009; 10.1373/clinchem.2009.127803 [Extract] [Full Text] [PDF]  

Interview:

Misia Landau

A Conversation with Dennis Hochstrasser
Clin Chem 2010 56: 321-326. Published online November 19, 2009; 10.1373/clinchem.2009.127829 [Extract] [Full Text] [PDF]  

Clinical Chemist:

Eric T. Fung

A Recipe for Proteomics Diagnostic Test Development: The OVA1 Test, from Biomarker Discovery to FDA Clearance
Clin Chem 2010 56: 327-329. [Extract] [Full Text] [PDF]  

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