Clinical Chemistry -- Papers in Press (section view)

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Clinical Chemistry Papers in Press: Last updated November 19, 2009 [View by date]

Effective with the December 2003 issue, authors' proofs of accepted articles are published online as they become available. The proofs are presented as PDFs, 3-5 weeks before their publication on paper or in their final on-line format. This "publication ahead of print", combined with other editorial changes, allows the publication of articles in half the time that was required 5-8 years ago.

EDITORIALS
Q&A
MINI-REVIEWS
PERSPECTIVES
MOLECULAR DIAGNOSTICS AND GENETICS
REVIEWS
POINT-OF-CARE TESTING
INTERVIEW
ENDOCRINOLOGY AND METABOLISM
INTRODUCTION
LETTERS TO THE EDITOR
LIPIDS, LIPOPROTEINS, AND CARDIOVASCULAR RISK FACTORS
REFLECTIONS
BRIEF COMMUNICATIONS
BRIEF COMMUNICATION
OTHER AREAS OF CLINICAL CHEMISTRY
PEDIATRIC CLINICAL CHEMISTRY
PROTEOMICS AND PROTEIN MARKERS
CITATION CLASSIC
DRUG MONITORING AND TOXICOLOGY
EVIDENCE-BASED MEDICINE AND TEST UTILIZATION
CORRECTION

To see an article, click its [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

EDITORIALS

David E. Bruns and James C. Boyd: Few Point-of-Care Hemoglobin A_1c Assay Methods Meet Clinical Needs
Clin Chem published November 19, 2009 as doi:10.1373/clinchem.2009.139865 [PDF]

Hans G. Schneider, Jill S. Tate, and Peter E. Hickman: What Criteria Should Be Used to Assess Troponin Assays?
Clin Chem published November 5, 2009 as doi:10.1373/clinchem.2009.137422 [PDF]

Stephen J. Freedland, Christina D. Williams, and Elizabeth M. Masko: Adiponectin and Prostate Cancer Mortality: To Be or Not to Be Skinny?
Clin Chem published November 5, 2009 as doi:10.1373/clinchem.2009.137406 [PDF]

Markus Otto: Dementia Diagnostics 2.0—Transfer from Research Studies into Routine Clinical Practice
Clin Chem published November 2, 2009 as doi:10.1373/clinchem.2009.136051 [PDF]

Matthew T. Flowers: The ${Delta}$ 9 Fatty Acid Desaturation Index as a Predictor of Metabolic Disease
Clin Chem published October 22, 2009 as doi:10.1373/clinchem.2009.135152 [PDF]

Rajyalakshmi Luthra and Zhuang Zuo: COLD-PCR Finds Hot Application in Mutation Analysis
Clin Chem published October 15, 2009 as doi:10.1373/clinchem.2009.136143 [PDF]

Marilyn A. Huestis: A New Ultraperformance–Tandem Mass Spectrometry Oral-Fluid Assay for 29 Illicit Drugs and Medications
Clin Chem published October 15, 2009 as doi:10.1373/clinchem.2009.134551 [PDF]

Yi-Wei Tang: Progress toward Rapid and Accurate Staphylococcus aureus Strain Typing
Clin Chem published October 8, 2009 as doi:10.1373/clinchem.2009.135707 [PDF]

Q&A

Mark Kellogg, Mark Hollis, Cheryl Gauthier, and Thomas O'Brien: Detection of Biological Agents Used for Terrorism: Are We Ready?
Clin Chem published November 19, 2009 as doi:10.1373/clinchem.2009.139493 [PDF]

Eleftherios P. Diamandis, Karl V. Voelkerding, Rade Drmanac, David Agus, and John McPherson: Next-Generation Sequencing: A New Revolution in Molecular Diagnostics?
Clin Chem published October 23, 2009 as doi:10.1373/clinchem.2009.133389 [PDF]

MINI-REVIEWS

Chad R. Borges, Doug S. Rehder, Jason W. Jarvis, Mathew R. Schaab, Paul E. Oran, and Randall W. Nelson: Full-Length Characterization of Proteins in Human Populations
Clin Chem published November 19, 2009 as doi:10.1373/clinchem.2009.134858 [Abstract] [PDF] [Supplement]

N. Leigh Anderson: The Clinical Plasma Proteome: A Survey of Clinical Assays for Proteins in Plasma and Serum
Clin Chem published November 2, 2009 as doi:10.1373/clinchem.2009.126706 [Abstract] [PDF] [Supplement]

PERSPECTIVES

Robert A. Dean and Leslie M. Shaw: Use of Cerebrospinal Fluid Biomarkers for Diagnosis of Incipient Alzheimer Disease in Patients with Mild Cognitive Impairment
Clin Chem published November 19, 2009 as doi:10.1373/clinchem.2009.134692 [PDF]

Kerunne Ketlogetswe and Roger S. Blumenthal: Thirty-Year Multivariate Risk Assessment Is a Stronger Predictor of Cardiovascular Disease than the 10-Year Model
Clin Chem published October 23, 2009 as doi:10.1373/clinchem.2009.134031 [PDF]

Tatsuya Sawamura: New Idol for Cholesterol Reduction?
Clin Chem published October 15, 2009 as doi:10.1373/clinchem.2009.134023 [PDF]

MOLECULAR DIAGNOSTICS AND GENETICS

Agata Zieba, Carolina Wählby, Fredrik Hjelm, Lee Jordan, Jonathan Berg, Ulf Landegren, and Katerina Pardali: Bright-Field Microscopy Visualization of Proteins and Protein Complexes by In Situ Proximity Ligation with Peroxidase Detection
Clin Chem published November 19, 2009 as doi:10.1373/clinchem.2009.134452 [Abstract] [PDF] [Supplement]

Lan-Szu Chou, C.-S. Jonathan Liu, Benjamin Boese, Xinmin Zhang, and Rong Mao: DNA Sequence Capture and Enrichment by Microarray Followed by Next-Generation Sequencing for Targeted Resequencing: Neurofibromatosis Type 1 Gene as a Model
Clin Chem published November 12, 2009 as doi:10.1373/clinchem.2009.132639 [Abstract] [PDF] [Supplement]

Nancy B.Y. Tsui, Ranjit Akolekar, Rossa W.K. Chiu, Katherine C.K. Chow, Tak Y. Leung, Tze K. Lau, Kypros H. Nicolaides, and Y.M. Dennis Lo: Synergy of Total PLAC4 RNA Concentration and Measurement of the RNA Single-Nucleotide Polymorphism Allelic Ratio for the Noninvasive Prenatal Detection of Trisomy 21
Clin Chem published November 5, 2009 as doi:10.1373/clinchem.2009.132662 [Abstract] [PDF] [Supplement]

Vanesa Dosil, Alicia Tosar, Carmen Cañadas, Pedro Pérez-Segura, Eduardo Díaz-Rubio, Trinidad Caldés, and Miguel de la Hoya: Alternative Splicing and Molecular Characterization of Splice Site Variants: BRCA1 c.591C>T as a Case Study
Clin Chem published November 5, 2009 as doi:10.1373/clinchem.2009.132274 [Abstract] [PDF]

Yu K. Tong, Shengnan Jin, Rossa W.K. Chiu, Chunming Ding, K.C. Allen Chan, Tak Y. Leung, Ling Yu, Tze K. Lau, and Y.M. Dennis Lo: Noninvasive Prenatal Detection of Trisomy 21 by an Epigenetic–Genetic Chromosome-Dosage Approach
Clin Chem published October 22, 2009 as doi:10.1373/clinchem.2009.134114 [Abstract] [PDF] [Supplement]

Rebecca W.Y. Chan, John Wong, Henry L.Y. Chan, Tony S.K. Mok, Wyatt Y.W. Lo, Vincent Lee, Ka F. To, Paul B.S. Lai, Timothy H. Rainer, Y.M. Dennis Lo, and Rossa W.K. Chiu: Aberrant Concentrations of Liver-Derived Plasma Albumin mRNA in Liver Pathologies
Clin Chem published October 15, 2009 as doi:10.1373/clinchem.2009.133355 [Abstract] [PDF] [Supplement]

Anders Ståhlberg, Martin Bengtsson, Martin Hemberg, and Henrik Semb: Quantitative Transcription Factor Analysis of Undifferentiated Single Human Embryonic Stem Cells
Clin Chem published October 8, 2009 as doi:10.1373/clinchem.2009.131433 [Abstract] [PDF]

Coren A. Milbury, Jin Li, and G. Mike Makrigiorgos: COLD-PCR–Enhanced High-Resolution Melting Enables Rapid and Selective Identification of Low-Level Unknown Mutations
Clin Chem published October 8, 2009 as doi:10.1373/clinchem.2009.131029 [Abstract] [PDF] [Supplement]

Eric J. White, Sergey V. Fridrikh, Nirupama Chennagiri, Douglas B. Cameron, Gregory P. Gauvin, and Rudolf Gilmanshin: Staphylococcus aureus Strain Typing by Single-Molecule DNA Mapping in Fluidic Microchips with Fluorescent Tags
Clin Chem published October 8, 2009 as doi:10.1373/clinchem.2009.128967 [Abstract] [PDF] [Supplement]

Steve E. Humphries, R. Dermot G. Neely, Roslyn A. Whittall, Jason S. Troutt, Robert J. Konrad, Marileia Scartezini, Ka Wah Li, Jackie A. Cooper, Jayshree Acharya, and Andrew Neil: Healthy Individuals Carrying the PCSK9 p.R46L Variant and Familial Hypercholesterolemia Patients Carrying PCSK9 p.D374Y Exhibit Lower Plasma Concentrations of PCSK9
Clin Chem published October 1, 2009 as doi:10.1373/clinchem.2009.129759 [Abstract] [PDF] [Supplement]

Thomas Hahn, Klaus S. Drese, and Ciara K. O'Sullivan: Microsystem for Isolation of Fetal DNA from Maternal Plasma by Preparative Size Separation
Clin Chem published October 1, 2009 as doi:10.1373/clinchem.2009.127480 [Abstract] [PDF]

REVIEWS

Amy K. Saenger and Robert H. Christenson: Stroke Biomarkers: Progress and Challenges for Diagnosis, Prognosis, Differentiation, and Treatment
Clin Chem published November 19, 2009 as doi:10.1373/clinchem.2009.133801 [Abstract] [PDF]

Walter E. Kelley, James L. Januzzi, and Robert H. Christenson: Increases of Cardiac Troponin in Conditions other than Acute Coronary Syndrome and Heart Failure
Clin Chem published October 8, 2009 as doi:10.1373/clinchem.2009.130799 [Abstract] [PDF]

POINT-OF-CARE TESTING

Erna Lenters-Westra and Robbert J. Slingerland: Six of 8 Hemoglobin A1c Point-of-Care Instruments Do Not Meet the General Accepted Analytical Performance Criteria
Clin Chem published November 19, 2009 as doi:10.1373/clinchem.2009.130641 [Abstract] [PDF]

INTERVIEW

Misia Landau: Dennis Hochstrasser Interview
Clin Chem published November 19, 2009 as doi:10.1373/clinchem.2009.127829 [PDF]

ENDOCRINOLOGY AND METABOLISM

Haojie Li, Meir J. Stampfer, Lorelei Mucci, Nader Rifai, Weiliang Qiu, Tobias Kurth, and Jing Ma: A 25-Year Prospective Study of Plasma Adiponectin and Leptin Concentrations and Prostate Cancer Risk and Survival
Clin Chem published November 12, 2009 as doi:10.1373/clinchem.2009.133272 [Abstract] [PDF]

Andreas Peter, Alexander Cegan, Silvia Wagner, Rainer Lehmann, Norbert Stefan, Alfred Königsrainer, Ingmar Königsrainer, Hans-Ulrich Häring, and Erwin Schleicher: Hepatic Lipid Composition and Stearoyl-Coenzyme A Desaturase 1 mRNA Expression Can Be Estimated from Plasma VLDL Fatty Acid Ratios
Clin Chem published October 22, 2009 as doi:10.1373/clinchem.2009.127274 [Abstract] [PDF] [Supplement]

INTRODUCTION

Glen L. Hortin, Steven A. Carr, and N. Leigh Anderson: Introduction: Advances in Protein Analysis for the Clinical Laboratory
Clin Chem published November 12, 2009 as doi:10.1373/clinchem.2009.132803 [PDF]

LETTERS TO THE EDITOR

Kareena L. Schnabl, P. Cheung Chan, and Khosrow Adeli: Reply
Clin Chem published November 5, 2009 as doi:10.1373/clinchem.2009.137109 [PDF]

Edward R. Smith: Analytical Considerations in the Investigation of Mixed Cryoglobulinemia
Clin Chem published November 2, 2009 as doi:10.1373/clinchem.2009.134502 [PDF]

Steven J. Soldin, Offie P. Soldin, Natasa Kahric-Janicic, and Jacquie Jonklaas: Reply
Clin Chem published October 15, 2009 as doi:10.1373/clinchem.2009.136432 [PDF]

Nic D. Christofides and John E. M. Midgley: Inaccuracies in Free Thyroid Hormone Measurement by Ultrafiltration and Tandem Mass Spectrometry
Clin Chem published October 15, 2009 as doi:10.1373/clinchem.2009.134593 [PDF]

Radha Ramachandran, Patricia Benfield, Waljit S. Dhillo, Sara White, Richard Chapman, Karim Meeran, Mandy Donaldson, and Niamh M. Martin: Need for Revision of Diagnostic Limits for Medullary Thyroid Carcinoma with a New Immunochemiluminometric Calcitonin Assay
Clin Chem published October 15, 2009 as doi:10.1373/clinchem.2009.129361 [PDF]

Robert E. Hruska and Jessie Shih: Cardiac Troponin Scorecard
Clin Chem published October 1, 2009 as doi:10.1373/clinchem.2009.135475 [PDF]

Holger de Wolf: In Reply
Clin Chem published October 1, 2009 as doi:10.1373/clinchem.2009.135038 [PDF]

Belén Prieto and Francisco V. Alvarez: Lack of Transferability of Results between Procalcitonin Assays
Clin Chem published October 1, 2009 as doi:10.1373/clinchem.2009.132605 [PDF]

Hiroyuki Hanada, Satami Mugii, Keiko Takeoka, Ikuhiro Maeda, Mikio Watanabe, Yoh Hidaka, and Yoshiori Iwatani: Early Detection of Colorectal Cancer Metastasis and Relapse by Recognizing Nonspecific Cross-Reacting Antigen 2 in Commercial Carcinoembryonic Antigen Assays
Clin Chem published June 25, 2009 as doi:10.1373/clinchem.2009.121897 [PDF]

LIPIDS, LIPOPROTEINS, AND CARDIOVASCULAR RISK FACTORS

Karsten Sydow, Stephen P. Fortmann, Joan M. Fair, Ann Varady, Mark A. Hlatky, Alan S. Go, Carlos Iribarren, Philip S. Tsao, and for the ADVANCE Investigators: Distribution of Asymmetric Dimethylarginine among 980 Healthy, Older Adults of Different Ethnicities
Clin Chem published November 5, 2009 as doi:10.1373/clinchem.2009.136200 [Abstract] [PDF]

REFLECTIONS

Norman G. Anderson: Adventures in Clinical Chemistry and Proteomics: A Personal Account
Clin Chem published November 5, 2009 as doi:10.1373/clinchem.2009.126680 [PDF]

BRIEF COMMUNICATIONS

Aleksandra Sikora, Bernhard G. Zimmermann, Corinne Rusterholz, Daniella Birri, Varaprasad Kolla, Olav Lapaire, Irene Hoesli, Vivian Kiefer, Laird Jackson, and Sinuhe Hahn: Detection of Increased Amounts of Cell-Free Fetal DNA with Short PCR Amplicons
Clin Chem published November 2, 2009 as doi:10.1373/clinchem.2009.132951 [Abstract] [PDF] [Supplement]

Florine Oca, Sophie Dreux, Bénédicte Gérard, Brigitte Simon-Bouy, Alix de Becdelièvre, Claude Ferec, Emmanuelle Girodon, and Françoise Muller: Amniotic Fluid Digestive Enzyme Analysis Is Useful for Identifying CFTR Gene Mutations of Unclear Significance
Clin Chem published October 15, 2009 as doi:10.1373/clinchem.2009.133298 [Abstract] [PDF]

Jürgen J. Wenzel, Heiko Walch, Markus Bollwein, Hans Helmut Niller, Waltraud Ankenbauer, Ralf Mauritz, Hans-Joachim Höltke, Héctor Manuel Zepeda, Hans Wolf, Wolfgang Jilg, and Udo Reischl: Library of Prefabricated Locked Nucleic Acid Hydrolysis Probes Facilitates Rapid Development of Reverse-Transcription Quantitative Real-Time PCR Assays for Detection of Novel Influenza A/H1N1/09 Virus
Clin Chem published October 1, 2009 as doi:10.1373/clinchem.2009.136192 [Abstract] [PDF] [Supplement]

BRIEF COMMUNICATION

Mark Hamer, Yoichi Chida, and Emmanuel Stamatakis: Association of Very Highly Elevated C-Reactive Protein Concentration with Cardiovascular Events and All-Cause Mortality
Clin Chem published November 2, 2009 as doi:10.1373/clinchem.2009.130740 [Abstract] [PDF]

Kuender D. Yang, Wan-Ching Chang, Hau Chuang, Pei-Wen Wang, Rue-Tsuan Liu, and Shu-Hui Yeh: Increased Complement Factor H with Decreased Factor B Determined by Proteomic Differential Displays as a Biomarker of Tai Chi Chuan Exercise
Clin Chem published November 2, 2009 as doi:10.1373/clinchem.2009.126615 [Abstract] [PDF] [Supplement]

OTHER AREAS OF CLINICAL CHEMISTRY

Stephanie Neuhold, Martin Huelsmann, Guido Strunk, Joachim Struck, Christopher Adlbrecht, Ghazaleh Gouya, Marie Elhenicky, and Richard Pacher: Prognostic Value of Emerging Neurohormones in Chronic Heart Failure during Optimization of Heart Failure–Specific Therapy
Clin Chem published November 2, 2009 as doi:10.1373/clinchem.2009.125856 [Abstract] [PDF]

Cees Mulder, Nicolaas A. Verwey, Wiesje M. van der Flier, Femke H. Bouwman, Astrid Kok, Evert J. van Elk, Philip Scheltens, and Marinus A. Blankenstein: Amyloid- ${beta}$ (1–42), Total Tau, and Phosphorylated Tau as Cerebrospinal Fluid Biomarkers for the Diagnosis of Alzheimer Disease
Clin Chem published October 15, 2009 as doi:10.1373/clinchem.2009.130518 [Abstract] [PDF]

Anna Vogiatzoglou, Abderrahim Oulhaj, A. David Smith, Eha Nurk, Christian A. Drevon, Per M. Ueland, Stein E. Vollset, Grethe S. Tell, and Helga Refsum: Determinants of Plasma Methylmalonic Acid in a Large Population: Implications for Assessment of Vitamin B₁₂ Status
Clin Chem published October 15, 2009 as doi:10.1373/clinchem.2009.128678 [Abstract] [PDF] [Supplement]

PEDIATRIC CLINICAL CHEMISTRY

Barbara W. Adam, Timothy H. Lim, Elizabeth M. Hall, and W. Harry Hannon: Preliminary Proficiency Testing Results for Succinylacetone in Dried Blood Spots for Newborn Screening for Tyrosinemia Type I
Clin Chem published October 22, 2009 as doi:10.1373/clinchem.2009.133819 [Abstract] [PDF]

PROTEOMICS AND PROTEIN MARKERS

Sonia Chalbot, Henrik Zetterberg, Kaj Blennow, Tormod Fladby, Inge Grundke-Iqbal, and Khalid Iqbal: Cerebrospinal Fluid Secretory Ca²⁺-Dependent Phospholipase A₂ Activity Is Increased in Alzheimer Disease
Clin Chem published October 22, 2009 as doi:10.1373/clinchem.2009.130286 [Abstract] [PDF]

CITATION CLASSIC

Eva Engvall: The ELISA, Enzyme-Linked Immunosorbent Assay
Clin Chem published October 22, 2009 as doi:10.1373/clinchem.2009.127803 [PDF]

Graeme Eisenhofer, David Goldstein, and Irwin Kopin: Simultaneous Liquid-Chromatographic Determination of Plasma Catecholamines and Metabolites
Clin Chem published October 15, 2009 as doi:10.1373/clinchem.2009.134478 [PDF]

DRUG MONITORING AND TOXICOLOGY

Eugene W. Schwilke, David M. Schwope, Erin L. Karschner, Ross H. Lowe, William D. Darwin, Deanna L. Kelly, Robert S. Goodwin, David A. Gorelick, and Marilyn A. Huestis: ${Delta}$ ⁹-Tetrahydrocannabinol (THC), 11-Hydroxy-THC, and 11-Nor-9-carboxy-THC Plasma Pharmacokinetics During and After Continuous High-Dose Oral THC
Clin Chem published October 15, 2009 as doi:10.1373/clinchem.2008.122119 [Abstract] [PDF] [Supplement]

EVIDENCE-BASED MEDICINE AND TEST UTILIZATION

Karina Rodríguez-Capote, Cynthia M. Balion, Stephen Hill, Richard Cleve, Lufang Yang, and Adell El Sharif: Utility of Urine Myoglobin for the Prediction of Acute Renal Failure in Subjects Where Rhabdomyolysis Is Suspected: A Systematic Review
Clin Chem published October 1, 2009 as doi:10.1373/clinchem.2009.128546 [Abstract] [PDF]

CORRECTION

Correction
Clin Chem published July 3, 2009 as doi:10.1373/clinchem.2009.131110 [PDF] [Supplement]